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Synthesis, characterisation and antimicrobial activities of novel 7,9-diphenyl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones

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Abstract

Some new 7,9-diaryl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones has been synthesised and their antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi, and antifungal activity against Candida albicans, Rhizopus sp., Aspergillus flavus and Aspergillus niger were examined. Compounds 14 and 15 against E. coli and S. typhi showed marked antibacterial activity. Similarly, compounds 13 and 15 against Rhizopus sp. and 13 and 14 against A. flavus exerted significant antifungal activities.

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Acknowledgements

We are thankful to Prof. K. Pandiarajan, Head, Department of Chemistry, Annamalai University for the facilities provided. One of the authors SK is grateful to Council of Scientific and Industrial Research, New Delhi, India for financial support in the form of Research Project. We also thank NMR Research Centre, IISc, Bangalore for providing all the NMR facilities to record NMR spectra.

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  1. Department of Chemistry, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India

    Senthamaraikannan Kabilan & Seeman Umamatheswari

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  1. Senthamaraikannan Kabilan
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  2. Seeman Umamatheswari
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Correspondence to Senthamaraikannan Kabilan.

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Kabilan, S., Umamatheswari, S. Synthesis, characterisation and antimicrobial activities of novel 7,9-diphenyl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones. Med Chem Res 20, 542–548 (2011). https://doi.org/10.1007/s00044-010-9348-8

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