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An efficient one-pot cyclization of quinoline thiosemicarbazones to quinolines derivatized with 1,3,4-thiadiazole as anticancer and anti-tubercular agents

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Abstract

A series of 6,7,8-substituted thiosemicarbazones (2a–j) of 2-chloro-3-formyl-quinoline derivatives were cyclized to the title compounds (3a–j) using acetic anhydride. The structures of the final compounds (3a–j) were confirmed by elemental and spectral (IR, 1H NMR and MS) analysis. Some of the title compounds have shown promising anticancer and antitubercular activities.

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Acknowledgments

The authors are thankful to the USIC, Karnatak University, Dharwad for carrying out the spectral (IR, 1H NMR, MS) and elemental analyses.

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Authors and Affiliations

  1. PG Department of Studies in Chemistry, Karnatak University, Dharwad, 580003, India

    Sheetal B. Marganakop, Ravindra R. Kamble, Tasneem Taj & Mahadevappa Y. Kariduraganvar

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  1. Sheetal B. Marganakop
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  2. Ravindra R. Kamble
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  3. Tasneem Taj
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  4. Mahadevappa Y. Kariduraganvar
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Correspondence to Ravindra R. Kamble.

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Marganakop, S.B., Kamble, R.R., Taj, T. et al. An efficient one-pot cyclization of quinoline thiosemicarbazones to quinolines derivatized with 1,3,4-thiadiazole as anticancer and anti-tubercular agents. Med Chem Res 21, 185–191 (2012). https://doi.org/10.1007/s00044-010-9522-z

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  • DOI: https://doi.org/10.1007/s00044-010-9522-z

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