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Benzimidazole: a medicinally important heterocyclic moiety

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Abstract

Benzimidazole nucleus is a constituent of many bioactive heterocyclic compounds that are of wide interest because of their diverse biological and clinical applications. Moreover, benzimidazole derivatives are structural isosters of naturally occurring nucleotides, which allows them to interact easily with the biopolymers of the living system. This created interest in researchers who have synthesized variety of benzimidazole derivatives and screened them for their various biological activities, viz., anticancer, hormone antagonist, antiviral, anti-HIV, anthelmintic, antiprotozoal, antimycobacterial, antihypertensive, anti-inflammatory, analgesic, anxiolytic, antiallergic, coagulant, anticoagulant, antioxidant as well antidiabetic activities.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India

    Balasubramanian Narasimhan & Pradeep Kumar

  2. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India

    Deepika Sharma

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  1. Balasubramanian Narasimhan
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  2. Deepika Sharma
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  3. Pradeep Kumar
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Correspondence to Balasubramanian Narasimhan.

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Narasimhan, B., Sharma, D. & Kumar, P. Benzimidazole: a medicinally important heterocyclic moiety. Med Chem Res 21, 269–283 (2012). https://doi.org/10.1007/s00044-010-9533-9

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