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Synthesis, characterization, and antibacterial activity of the ligands including thiophene/furan ring systems and their Cu(II), Zn(II) complexes

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Abstract

Carboxamide complexes having general formula as [ML]Cl2·nH2O (where M = Cu(II), Zn(II); n = 0, 1/2) were synthesized using heterocyclic carboxamide ligands: 1,4-bis[3-(2-thiophenecarboxamido)propyl]piperazine (L1) and 1,4-bis[3-(2-furancarboxamido) propyl]piperazine (L2). Their structures were characterized with elemental analysis, molar conductivity, magnetic susceptibility, and spectral methods (1H-NMR, 13C-NMR, FT-IR, LC-MS). TGA and DTA curves were also performed. The structure–activity relationship for the ligands was investigated using PM3 semi-empirical method. The antibacterial activities of the carboxamides and their complexes were investigated against bacteria; Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 11230, Bacillus magaterium RSKK 5117, B. cereus RSKK 863, Salmonella enteritidis ATCC 13076, B. subtilis RSKK 244 using microdilution method.

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Acknowledgment

The authors thank the Gazi University, vide Project no (05/2007–09) for financial support.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Gazi University, Ankara, Turkey

    Ayla Balaban Gündüzalp & Nurcan Karacan

  2. Elementary Science Education, Faculty of Education, Ahi Evran University, Kırşehir, Turkey

    Neslihan Özbek

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  1. Ayla Balaban Gündüzalp
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  2. Neslihan Özbek
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  3. Nurcan Karacan
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Correspondence to Ayla Balaban Gündüzalp.

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Balaban Gündüzalp, A., Özbek, N. & Karacan, N. Synthesis, characterization, and antibacterial activity of the ligands including thiophene/furan ring systems and their Cu(II), Zn(II) complexes. Med Chem Res 21, 3435–3444 (2012). https://doi.org/10.1007/s00044-011-9878-8

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