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Recent advances and therapeutic journey of coumarins: current status and perspectives

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Abstract

Coumarins are oxygen-containing molecules with specific benzopyrone nucleus. Different coumarins are identified as antineurodegeneratives, anticoagulants, antioxidants, antimicrobials, anticancers, antivirals, antidiabetics, antidepressants, supramoleculars, antiparasitics, anti-inflammatory, analgesics, biological stains, pathological probes and diagnostics. Coumarins have received more attention as compared to 1-azacoumarins. Many attempts have been made for the comparison of both the systems at different stages to discover novel synthetic methodologies, reactivity strategies and biological activities. Translation of current knowledge into novel potent lead compounds and repositioning of well-known compounds for the treatment of different acute and chronic diseases are the current challenges of coumarins. This review article focusses on the occurence, synthesis and specific biological activities of various coumarin derivatives. Some novel research approaches are also described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies. Cellular and molecular mechanisms of coumarins involved in SAR studies are also described.

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Acknowledgments

Authors would like to thank Ministry of Health & Family Welfare, INSPIRE Program, Department of Science & Technology (DST), Govt. of India for providing INSPIRE Fellowship which helps as financial support. Shailesh Jain is supported by CSIR-SRF fellowship. Shubhra Singh is supported by a Raman-Charpak Fellowship, and is thankful to IFTM University, Moradabad for registering her in their University.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, 382481, Gujarat, India

    Kuldipsinh P. Barot, Shailesh V. Jain & Manjunath D. Ghate

  2. Laboratoire de Dynamique des Interactions Normales et Pathologiques, CNRS UMR 5235, Université Montpellier 2, Eugène Bataillon, 34095, Montpellier Cedex 5, France

    Laurent Kremer & Shubhra Singh

  3. INSERM, DIMNP, Place Eugène Bataillon, 34095, Montpellier Cedex 05, France

    Laurent Kremer

  4. IFTM University, Lodhipur Rajput, Delhi Road, Moradabad, 244102, Uttar Pradesh, India

    Shubhra Singh

  5. Central Drug Research Institute, CSIR, Sector-10, Sitapur Road, Lucknow, 226031, India

    Shubhra Singh

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  1. Kuldipsinh P. Barot
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Correspondence to Manjunath D. Ghate.

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Barot, K.P., Jain, S.V., Kremer, L. et al. Recent advances and therapeutic journey of coumarins: current status and perspectives. Med Chem Res 24, 2771–2798 (2015). https://doi.org/10.1007/s00044-015-1350-8

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