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Molecular characteristics of community-associated methicillin-resistant Staphylococcus aureus strains for clinical medicine

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Abstract

Infections caused by methicillin-resistant S. aureus strains are mainly associated with a hospital setting. However, nowadays, the MRSA infections of non-hospitalized patients are observed more frequently. In order to distinguish them from hospital-associated methicillin-resistant S. aureus (HA-MRSA) strains, given them the name of community-associated methicillin-resistant S. aureus (CA-MRSA). CA-MRSA strains most commonly cause skin infections, but may lead to more severe diseases, and consequently the patient’s death. The molecular markers of CA-MRSA strains are the presence of accessory gene regulator (agr) of group I or III, staphylococcal cassette chromosome mec (SCCmec) type IV, V or VII and genes encoding for Panton–Valentine leukocidin (PVL). In addition, CA-MRSA strains show resistance to β-lactam antibiotics. Studies on the genetic elements of CA-MRSA strains have a key role in the unambiguous identification of strains, monitoring of infections, improving the treatment, work on new antimicrobial agents and understanding the evolution of these pathogens.

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Acknowledgments

This work was supported by the grant no. 2370/B/P01/2008/34 (N N401237034) from the Ministry of Science and Higher Education (MNiSW), by the grant for young investigators, The Foundation for the Development of Gdansk University and by the European Union within the European Social Fund in the framework of the project “InnoDoktorant - Scholarships for PhD students, I edition”.

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  1. Laboratory of Molecular Diagnostics, Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Kladki 24, 80-822, Gdansk, Poland

    Paulina Nastaly, Mariusz Grinholc & Krzysztof P. Bielawski

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  1. Paulina Nastaly
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  2. Mariusz Grinholc
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  3. Krzysztof P. Bielawski
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Correspondence to Mariusz Grinholc.

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Communicated by Sebastian Suerbaum.

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Nastaly, P., Grinholc, M. & Bielawski, K.P. Molecular characteristics of community-associated methicillin-resistant Staphylococcus aureus strains for clinical medicine. Arch Microbiol 192, 603–617 (2010). https://doi.org/10.1007/s00203-010-0594-4

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