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Surface acoustic wave biosensors: a review

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Abstract

This review presents an overview of 20 years of worldwide development in the field of biosensors based on special types of surface acoustic wave (SAW) devices that permit the highly sensitive detection of biorelevant molecules in liquid media (such as water or aqueous buffer solutions). 1987 saw the first approaches, which used either horizontally polarized shear waves (HPSW) in a delay line configuration on lithium tantalate (LiTaO3) substrates or SAW resonator structures on quartz or LiTaO3 with periodic mass gratings. The latter are termed “surface transverse waves” (STW), and they have comparatively low attenuation values when operated in liquids. Later Love wave devices were developed, which used a film resonance effect to significantly reduce attenuation. All of these sensor approaches were accompanied by the development of appropriate sensing films. First attempts used simple layers of adsorbed antibodies. Later approaches used various types of covalently bound layers, for example those utilizing intermediate hydrogel layers. Recent approaches involve SAW biosensor devices inserted into compact systems with integrated fluidics for sample handling. To achieve this, the SAW biosensors can be embedded into micromachined polymer housings. Combining these two features will extend the system to create versatile biosensor arrays for generic lab use or for diagnostic purposes.

SAW based biosensor immersed in a sample flow. Analyte molecules binding to the immobilized antibodies on the sensor surface will influence the velocity of the SAW and hence the output signal generated by the driving electronics.

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References

  1. White RM, Voltmer FW (1965) Appl Phys Lett 7:314–316

    Article  Google Scholar 

  2. Grate JW, Frye GC (1996) Acoustic wave sensors. In: Baltes H, Göpel W, Hesse J (eds) Sensors update, vol 2. Wiley-VCH, Weinheim

  3. Wohltjen H, Dessy R (1979) Anal Chem 51:1458–1464

    Article  CAS  Google Scholar 

  4. Wohltjen H, Dessy R (1979) Anal Chem 51:1465–1470

    Article  CAS  Google Scholar 

  5. Wohltjen H, Dessy R (1979) Anal Chem 51:1470–1475

    Article  CAS  Google Scholar 

  6. Caliendo C, Verardi P, Verona E, D'Amico A, Di Natale C, Saggio G, Serafini M, Paolesse R, Huq SE (1997) Smart Mater Struct 6:689–699

    Article  CAS  Google Scholar 

  7. Mah C, Thurbide KB (2006) J Sep Sci 29:1922–1930

    Article  CAS  Google Scholar 

  8. Roederer JE, Bastiaans GJ (1983) Anal Chem 55:2333–2336

    Article  CAS  Google Scholar 

  9. Calabrese GS, Wohltjen H, Roy MK (1987) Anal Chem 59:833–837

    Article  CAS  Google Scholar 

  10. Andle JC, Vetelino JF (1994) Sens Actuators A 44:167–176

    Article  Google Scholar 

  11. Shons A, Dorman F, Najarian J (1972) J Biomed Mater Res 6:565–570

    Article  CAS  Google Scholar 

  12. Thompson M, Arthur CL, Dhaliwal GK (1986) Anal Chem 58:1206–1209

    Article  CAS  Google Scholar 

  13. Davis KA, Leary TR (1989) Anal Chem 61:1227–1230

    Article  CAS  Google Scholar 

  14. Janshoff A, Steinem C (2001) Quartz crystal microbalance for bioanalytical applications. In: Baltes H, Hesse J, Korvink JG (eds) Sensors update, vol 9. Wiley-VCH, Weinheim

  15. Cooper MA, Singleton VT (2007) J Mol Recognit 20:154–184

    Article  CAS  Google Scholar 

  16. Wohltjen H (1984) Sens Actuators 5:307–325

    Article  CAS  Google Scholar 

  17. Vellekoop MJ (1998) Ultrasonics 36:7–14

    Article  Google Scholar 

  18. Martin SJ, Ricco AJ, Niemczyk TM, Frye GC (1989) Sens Actuators 20:253–268

    Article  CAS  Google Scholar 

  19. Dahint R, Bender F, Morhard F (1999) Anal Chem 71:3150–3156

    Article  CAS  Google Scholar 

  20. Vellekoop MJ, Lubking GW, Sarro PM, Venema A (1994) Sens Actuators A 44:249–263

    Article  CAS  Google Scholar 

  21. Wu Y, de Labachelerie M, Bastien F (2002) Sens Actuators A 100:214–222

    Article  Google Scholar 

  22. Galipeau DW, Story PR, Vetelino KA, Mileham RD (1997) Smart Mater Struct 6:658–667

    Article  CAS  Google Scholar 

  23. Drobe H, Leidl A, Rost M, Ruge I (1993) Sens Actuators A 37–38:141–148

    Article  Google Scholar 

  24. Leidl A, Oberlack I, Schaber U, Mader B, Drost S (1997) Smart Mater Struct 6:680–688

    Article  CAS  Google Scholar 

  25. Lide DR (2000–2001) CRC handbook of chemistry and physics. CRC Press, Boca Raton, FL

  26. Flory CA, Baer RL (1987) Proc IEEE Ultrason Symp 1987:313–318

    Google Scholar 

  27. Shiokawa S, Moriizumi T (1987) Design of SAW sensor in liquid (in Proc 8th Symp Ultrason Electron). Jpn J Appl Phys 1988(27–1):142–144

  28. Thompson DF, Auld BA (1986) Proc IEEE Ultrason Symp 1986:261–266

    Google Scholar 

  29. Baer RL, Flory CA, Tom-Moy M, Spira-Solomon D (1992) Proc IEEE Ultrason Symp 1992:293–298

    Article  Google Scholar 

  30. Inoue Y, Kato Y, Sato K (1992) J Chem Soc Faraday Trans 88:449–454

    Article  CAS  Google Scholar 

  31. Kondoh J, Matsui Y, Shiokawa S (1993) Jpn J Appl Phys 32:2376–2379

    Article  CAS  Google Scholar 

  32. Rapp M, Moss DA, Reichert J, Ache HJ (1993) 7th Int Conf Solid State Sensors and Actuators (Transducers '93), Yokohama, Japan, 7–10 June 1993, pp 538–540

  33. Love AEH (1911) Some problems of geodynamics. Cambridge University Press, Cambridge

  34. Gizeli E, Goddard NJ, Lowe CR, Stevenson AC (1992) Sens Actuators B 6:131–137

    Article  Google Scholar 

  35. Gizeli E, Stevenson AC, Goddard NJ, Lowe CR (1992) IEEE Trans Ultrason Ferroelectr Freq Control 39:657–659

    Article  CAS  Google Scholar 

  36. Stevenson AC, Gizeli E, Goddard NJ, Lowe CR (1993) Sens Actuators B 13–14:635–637

    Article  Google Scholar 

  37. Kovacs G, Venema A (1992) Appl Phys Lett 61:639–641

    Article  CAS  Google Scholar 

  38. Kovacs G, Lubking GW, Vellekoop MJ, Venema A (1992) Proc IEEE Ultrason Symp 1992:281–285

    Article  Google Scholar 

  39. Kovacs G, Vellekoop MJ, Haueis R, Lubking GW, Venema A (1994) Sens Actuators A 43:38–43

    Article  CAS  Google Scholar 

  40. Du J, Harding GL, Ogilvy JA, Dencher PR, Lake M (1996) Sens Actuators A 56:211–219

    Article  Google Scholar 

  41. Harding GL, Du J, Dencher PR, Barnett D, Howe E (1997) Sens Actuators A 61:279–286

    Article  Google Scholar 

  42. Rapp M, Wessa T, Ache HJ (1995) Proc IEEE Ultrason Symp 1995:433–436

    Google Scholar 

  43. Wessa T, Barié N, Rapp M, Ache HJ (1998) Sens Actuators B 53:63–68

    Article  Google Scholar 

  44. Barié N, Rapp, M, Sigrist H, Ache HJ (1998) Biosens Bioelectron 13:855–860

    Article  Google Scholar 

  45. Barié N, Sigrist H, Rapp M (1999) Analusis 27:622–629

    Article  Google Scholar 

  46. Wessa T, Rapp M, Ache HJ (1999) Biosens Bioelectron 14:93–98

    Article  CAS  Google Scholar 

  47. Wessa T, Rapp M, Sigrist H (1999) Colloids Surf B 15:139–146

    Article  CAS  Google Scholar 

  48. Barié N, Rapp M (2001) Biosens Bioelectron 16:979–987

    Article  Google Scholar 

  49. Länge K, Bender F, Voigt A, Gao H, Rapp M (2003) Anal Chem 75:5561–5566

    Article  CAS  Google Scholar 

  50. Bender F, Länge K, Voigt A, Rapp M (2004) Anal Chem 76:3837–3840

    Article  CAS  Google Scholar 

  51. Tom-Moy M, Baer RL, Spira-Solomon D, Doherty TP (1995) Anal Chem 67:1510–1516

    Article  CAS  Google Scholar 

  52. Grate JW, Klusty M (1991) Anal Chem 63:1719–1727

    Article  CAS  Google Scholar 

  53. Länge K, Voigt A, Rapp M (2003) Proc IEEE Sens 2003:1174–1178

    Google Scholar 

  54. Länge K, Grimm S, Rapp M (2007) Sens Actuators B 125:441–446

    Article  CAS  Google Scholar 

  55. Bender F, Länge K, Barié N, Kondoh J, Rapp M (2004) Langmuir 20:2315–2319

    Article  CAS  Google Scholar 

  56. Thévenot DR, Toth K, Durst RA, Wilson GS (1999) Pure Appl Chem 71:2333–2348

    Article  Google Scholar 

  57. Collings AF, Caruso F (1997) Rep Prog Phys 60:1397–1445

    Article  CAS  Google Scholar 

  58. Rasmusson A, Gizeli E (2001) J Appl Phys 90:5911–5914

    Article  CAS  Google Scholar 

  59. Gizeli E, Lowe CR, Liley M, Vogel H (1996) Sens Actuators B 34:295–300

    Article  Google Scholar 

  60. Saha K, Bender F, Gizeli E (2003) Anal Chem 75:835–842

    Article  CAS  Google Scholar 

  61. Gizeli E, Bender F, Rasmusson A, Saha K, Josse F, Cernosek R (2003) Biosens Bioelectron 18:1399–1406

    Article  CAS  Google Scholar 

  62. Hoummadi M, Campitelli A, Wlodarski W (1997) Smart Mater Struct 6:647–657

    Article  Google Scholar 

  63. Josse F, Bender F, Cernosek RW (2001) Anal Chem 73:5937–5944

    Article  CAS  Google Scholar 

  64. Schlensog MD, Gronewold TMA, Tewes M, Famulok M, Quandt E (2004) Sens Actuators B 101:308–315

    Article  CAS  Google Scholar 

  65. Gronewold TMA, Glass S, Quandt E, Famulok M (2005) Biosens Bioelectron 20:2044–2052

    Article  CAS  Google Scholar 

  66. Perpeet M, Glass S, Gronewold T, Kiwitz A, Malavé A, Stoyanov I, Tewes M, Quandt E (2006) Anal Lett 39:1747–1757

    Article  CAS  Google Scholar 

  67. Jung A, Gronewold TMA, Tewes M, Quandt E, Berlin P (2007) Sens Actuators B 124:46–52

    Article  CAS  Google Scholar 

  68. Dubrovsky T, Tronin A, Dubrovskaya S, Guryev O, Nicolini C (1996) Thin Solid Films 284–285:698–702

    Article  Google Scholar 

  69. Welsch W, Klein C, von Schickfus M, Hunklinger S (1996) Anal Chem 68:2000–2004

    Article  CAS  Google Scholar 

  70. Freudenberg J, Schelle K, Beck M, von Schickfus M, Hunklinger S (1999) Biosens Bioelectron 14:427–429

    Article  Google Scholar 

  71. Freudenberg J, von Schickfus M, Hunklinger S (2001) Sens Actuators B 76:147–151

    Article  Google Scholar 

  72. Kwon Y, Roh Y (2004) Ultrasonics 42:409–411

    Article  CAS  Google Scholar 

  73. Cooper MA (2003) Anal Bioanal Chem 377:834–842

    Article  CAS  Google Scholar 

  74. Sigrist H, Collioud A, Clémence JF, Gao H, Luginbühl R, Sänger M, Sundarababu G (1995) Opt Eng 34:2339–2348

    Article  CAS  Google Scholar 

  75. Gizeli E, Liley M, Lowe CR, Vogel H (1997) Anal Chem 69:4808–4813

    Article  CAS  Google Scholar 

  76. Gizeli E, Glad J (2004) Anal Chem 76:3995–4001

    Article  CAS  Google Scholar 

  77. Chang HW, Shih JS (2007) Sens Actuators B 121:522–529

    Article  CAS  Google Scholar 

  78. Hur Y, Han J, Seon J, Pak YE, Roh Y (2005) Sens Actuators A 120:462–467

    Article  CAS  Google Scholar 

  79. Sakong J, Roh H, Roh Y (2007) Jpn J Appl Phys 46:4729–4733

    Article  CAS  Google Scholar 

  80. Gronewold TMA, Baumgartner A, Quandt E, Famulok M (2006) Anal Chem 78:4865–4871

    Article  CAS  Google Scholar 

  81. Tamarin O, Comeau S, Déjous C, Moynet D, Rebière D, Bezian J, Pistré J (2003) Biosens Bioelectron 18:755–763

    Article  CAS  Google Scholar 

  82. Howe E, Harding G (2000) Biosens Bioelectron 15:641–649

    Article  CAS  Google Scholar 

  83. Moll N, Pascal E, Dinh DH, Pillot JP, Bennetau B, Rebière D, Moynet D, Mas Y, Mossalayi D, Pistré J, Déjous C (2007) Biosens Bioelectron 22:2145–2150

    Article  CAS  Google Scholar 

  84. Branch DW, Brozik SM (2004) Biosens Bioelectron 19:849–859

    Article  CAS  Google Scholar 

  85. Berkenpas E, Millard P, Pereira da Cunha M (2006) Biosens Bioelectron 21:2255–2262

    Article  CAS  Google Scholar 

  86. Kondoh J, Matsui Y, Shiokawa S, Wlodarski WB (1994) Sens Actuators B 20:199–203

    Article  CAS  Google Scholar 

  87. Gizeli E (1997) Smart Mater Struct 6:700–706

    Article  CAS  Google Scholar 

  88. Dickert FL, Tortschanoff M, Bulst WE, Fischerauer G (1999) Anal Chem 71:4559–4563

    Article  CAS  Google Scholar 

  89. Stubbs DD, Hunt WD, Lee SH, Doyle DF (2002) Biosens Bioelectron 17:471–477

    Article  CAS  Google Scholar 

  90. Stubbs DD, Lee SH, Hunt WD (2003) Anal Chem 75:6231–6235

    Article  CAS  Google Scholar 

  91. Tanguay LF, Sawan M (2006) IEEE APCCS 2006:494–497

  92. Leonte I, Hunt M, Sehra G, Cole M, Gardner JW (2004) SAW bioliquids sensor with RF interrogation. In: High Frequency Postgraduate Student Colloquium, Warwick Univ, UK, 6–7 Sept 2004, pp 47–52

  93. Cass T, Toumazou C (2006) S7: State-of-Science Review: Biosensors and biomarkers. In: Foresight infectious diseases: preparing for the future. Department of Trade and Industry, London (see http://www.foresight.gov.uk, accessed 30 Jan 2008)

  94. Tigli O, Zaghloul ME (2007) IEEE Sens J 7:219–227

    Article  CAS  Google Scholar 

  95. Lec RM (2001) IEEE Int Freq Control Symp & PDA Exhib 2001:419–429

  96. Coté GL, Lec RM, Pishko MV (2003) IEEE Sens J 3:251–266

    Article  CAS  Google Scholar 

  97. Kress-Rogers E (1997) Handbook of biosensors and electronic noses: medicine, food and environment. CRC Press, Boca Raton, FL

  98. Cole M, Gardner JW, Leonte II, Sehra G, Noh HS, Hesketh PJ (2005) Proc IEEE Sens 2005:1300–1303

    Article  Google Scholar 

  99. Francis LA, Friedt JM, Bartic C, Campitelli A (2004) Proc SPIE 5455:353–363

    Article  Google Scholar 

  100. Länge K, Blaess G, Voigt A, Götzen R, Rapp M (2006) Biosens Bioelectron 22:227–232

    Article  CAS  Google Scholar 

  101. Rapp B, Länge K, Rapp M, Guber A (2007) Surface acoustic wave biosensors for biomedical applications. In: Biomedizinische Technik (BMT), Aachen, Germany, 26–29 Sept 2007

  102. Center of Advanced European Studies and Research (Bonn), Nanofilm Technology GmbH (2007 The S-Sens-System. http://www.s-sens.de, accessed 30 Jan 2008

  103. Joseph S, Gronewold TMA, Schlensog MD, Olbrich C, Quandt E, Famulok M, Schirner M (2005) Biosens Bioelectron 20:1829–1835

    Article  CAS  Google Scholar 

  104. Gronewold TMA, Schlecht U, Quandt E (2007) Biosens Bioelectron 22:2360–2365

    Article  CAS  Google Scholar 

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  1. Institute for Microstructure Technology, Forschungszentrum Karlsruhe, P.O. Box 3670, 76021, Karlsruhe, Germany

    Kerstin Länge, Bastian E. Rapp & Michael Rapp

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  1. Kerstin Länge
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  2. Bastian E. Rapp
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Correspondence to Kerstin Länge.

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Länge, K., Rapp, B.E. & Rapp, M. Surface acoustic wave biosensors: a review. Anal Bioanal Chem 391, 1509–1519 (2008). https://doi.org/10.1007/s00216-008-1911-5

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