Abstract
Rats were trained on an operant task and then received striatal lesions and grafts. Grafts were derived either from whole-ganglionic eminences or restricted to the lateral eminence. When retested 4 months later; graft-associated behavioural recovery was only apparent with extensive retesting. There was no difference in performance between rats that received whole-dissection or lateral-dissection grafts, and no correlation between performance and the amount of striatal-like (P-zone) tissue within the graft. It is suggested that P-zone reconstruction may be necessary, but not sufficient for behavioural recovery, which may additionally depend upon rehabilitative training.
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Received: 20 May 1999 / Accepted: 2 July 1999
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Brasted, P., Watts, C., Torres, E. et al. Behavioural recovery following striatal transplantation: effects of postoperative training and P-zone volume. Exp Brain Res 128, 535–538 (1999). https://doi.org/10.1007/s002210050877
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DOI: https://doi.org/10.1007/s002210050877