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Obesity-related indices and its association with kidney stone disease: a cross-sectional and longitudinal cohort study

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Abstract

Obesity increases the risk of several diseases, including kidney stone disease (KSD). The study aimed to explore the relationship between KSD and various obesity-related indices. A total of 121,605 participants in the Taiwan Biobank from December 2008 to February 2020 were analyzed. The association between self-reported history of KSD and eight obesity-related indices, including body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), abdominal volume index (AVI), body roundness index (BRI), conicity index, and triglyceride glucose index was examined in cross-sectional analysis; additionally, the risk of developing kidney stones was analyzed in a longitudinal cohort of 25,268 participants without KSD at baseline, which was a subset of the main cohort. Of all participants, 77,904 (64.1%) were female. Overall, 10.7% of males and 4.0% of females had KSD. Multivariate-adjusted logistic regression showed that all obesity-related indices were significantly associated with KSD. During a mean follow-up of 47 months, kidney stones occurred in 642 (2.5%) participants, and after adjusting for confounders, the risk of developing kidney stones was higher in participants with higher BMI, WC, WHtR, WHR, AVI and BRI. BMI, WC, WHtR, WHR, AVI, and BRI were found to be associated with a higher prevalence of kidney stones as well as development of incident kidney stones, which could be used as predictive factors for development of KSD in clinical practice.

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Acknowledgements

This work was supported partially by the Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan and by Kaohsiung Medical University Research Center Grant (KMU-TC109A01-1).

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Authors and Affiliations

  1. Department of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan

    Ming-Ru Lee & Jiun-Hung Geng

  2. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

    Ming-Ru Lee, Hung-Lung Ke, Shu-Pin Huang & Jiun-Hung Geng

  3. Kaohsiung Medical University, Kaohsiung, Taiwan

    Ming-Ru Lee, Hung-Lung Ke, Shu-Pin Huang & Jiun-Hung Geng

  4. Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Hung-Lung Ke

  5. Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Hung-Lung Ke, Shu-Pin Huang & Jiun-Hung Geng

  6. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Hung-Lung Ke

  7. Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

    Jiun-Chi Huang

  8. Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

    Jiun-Chi Huang

  9. Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Jiun-Chi Huang

  10. Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Jiun-Chi Huang & Jiun-Hung Geng

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  1. Ming-Ru Lee
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Correspondence to Jiun-Hung Geng.

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Lee, MR., Ke, HL., Huang, JC. et al. Obesity-related indices and its association with kidney stone disease: a cross-sectional and longitudinal cohort study. Urolithiasis 50, 55–63 (2022). https://doi.org/10.1007/s00240-021-01288-w

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