Skip to main content
SpringerLink
Log in

Role of plant phytochemicals and microbial enzymes in biosynthesis of metallic nanoparticles

  • Mini-Review
  • Published:
Applied Microbiology and Biotechnology Aims and scope Submit manuscript

Abstract

Metal-based nanoparticles have gained tremendous popularity because of their interesting physical, biological, optical, and magnetic properties. These nanoparticles can be synthesized using a variety of different physical, chemical, and biological techniques. The biological means are largely preferred as it provides an environmentally benign, green, and cost-effective route for the biosynthesis of nanoparticles. These bioresources can act as a scaffold, thereby playing the role of reducing as well as capping agents in the biosynthesis of nanoparticles. Medicinal plants tend to have a complex phytochemical constituent such as alcohols, phenols, terpenes, alkaloids, saponins, and proteins, while microbes have key enzymes which can act as reducing as well as stabilizing agent for NP synthesis. However, the mechanism of biosynthesis is still highly debatable. Herein, the present review is directed to give an updated comprehensive overview towards the mechanistic aspects in the biosynthesis of nanoparticles via plants and microbes. Various biosynthetic pathways of secondary metabolites in plants and key enzyme production in microbes have been discussed in detail, along with the underlying mechanisms for biogenic NP synthesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  • Ahmad N, Sharma S, Alam MK, Singh V, Shamsi S, Mehta B, Fatma A (2010) Rapid synthesis of silver nanoparticles using dried medicinal plant of basil. Colloids Surf B Biointerfaces 81:81–86

    Article  PubMed  CAS  Google Scholar 

  • Ajitha B, Reddy YAK, Reddy PS (2015) Green synthesis and characterization of silver nanoparticles using Lantana camara leaf extract. Mater Sci Eng C 49:373–381

    Article  CAS  Google Scholar 

  • Ali M, Khan T, Fatima K, Ali QUA, Ovais M, Khalil AT, Ullah I, Raza A, Shinwari ZK, Idrees M (2017) Selected hepatoprotective herbal medicines: evidence from ethnomedicinal applications, animal models, and possible mechanism of actions. Phytother Res 31:1–17

    Article  CAS  Google Scholar 

  • Anwar A, Ovais M, Khan A, Raza A (2017) Docetaxel loaded solid lipid nanoparticles: a novel drug delivery system. IET Nanobiotechnol 11:1–34

    Article  Google Scholar 

  • Aromal SA, Vidhu V, Philip D (2012) Green synthesis of well-dispersed gold nanoparticles using Macrotyloma uniflorum. Spectrochim Acta A 85:99–104

    Article  CAS  Google Scholar 

  • Ashraf S, Abbasi AZ, Pfeiffer C, Hussain SZ, Khalid ZM, Gil PR, Parak WJ, Hussain I (2013) Protein-mediated synthesis, pH-induced reversible agglomeration, toxicity and cellular interaction of silver nanoparticles. Colloids Surf B Biointerfaces 102:511–518

    Article  PubMed  CAS  Google Scholar 

  • Awan U, Ali S, Rehman M, Zia N, Sohaila S, Ovais M, Raza A (2017) Stable and reproducible synthesis of gold nanorods for biomedical applications: a comprehensive study. IET Nanobiotechnol 12:182–190. https://doi.org/10.1049/iet-nbt.2016.0220

    Article  Google Scholar 

  • Ayaz M, Junaid M, Ullah F, Sadiq A, Ovais M, Ahmad W, Zeb A (2016) Chemical profiling, antimicrobial and insecticidal evaluations of Polygonum hydropiper L. BMC Complement Altern Med 16:502. https://doi.org/10.1186/s12906-016-1491-4

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ayaz M, Junaid M, Ullah F, Subhan F, Sadiq A, Ali G, Ovais M, Shahid M, Ahmad A, Wadood A, El-Shazly M (2017) Anti-Alzheimer’s studies on β-sitosterol isolated from Polygonum hydropiper L. Front Pharmacol 8:697. https://doi.org/10.3389/fphar.2017.00697

    Article  PubMed  PubMed Central  Google Scholar 

  • Barabadi H, Alizadeh A, Ovais M, Ahmadi A, Shinwari Z, Muthupandian S (2017a) The efficacy of green nanoparticles against cancerous and normal cell lines: a systematic review and meta-analysis. IET Nanobiotechnol 12:377–391. https://doi.org/10.1049/iet-nbt.2017.0120

    Article  Google Scholar 

  • Barabadi H, Ovais M, Shinwari ZK, Saravanan M (2017b) Anti-cancer green bionanomaterials: present status and future prospects. Green Chem Lett Rev 10:285–314

    Article  CAS  Google Scholar 

  • Bell EA, Charlwood BV (1980) Secondary plant products.[Encyclopedia of Plant Physiology]. Springer-Verlag, Berlin

    Book  Google Scholar 

  • Bindhani B, Panigrahi A (2014) Green synthesis of gold nanoparticles using neem (Azadirachta indica L.) leaf extract and its biomedical applications. Int J Adv Biotechnol Res 5:457–464

    Google Scholar 

  • Bose D, Chatterjee S (2016) Biogenic synthesis of silver nanoparticles using guava (Psidium guajava) leaf extract and its antibacterial activity against Pseudomonas aeruginosa. Appl Nanosci 6:895–901

    Article  CAS  Google Scholar 

  • Da Silva E, Da Silva M, Meneghetti S, Machado G, Alencar M, Hickmann J, Meneghetti M (2008) Synthesis of colloids based on gold nanoparticles dispersed in castor oil. J Nanopart Res 10:201–208

    Article  CAS  Google Scholar 

  • Dauthal P, Mukhopadhyay M (2013) Biosynthesis of palladium nanoparticles using Delonix regia leaf extract and its catalytic activity for nitro-aromatics hydrogenation. Ind Eng Chem Res 52:18131–18139

    Article  CAS  Google Scholar 

  • Dauthal P, Mukhopadhyay M (2016a) Noble metal nanoparticles: plant-mediated synthesis, mechanistic aspects of synthesis, and applications. Ind Eng Chem Res 55:9557–9577

    Article  CAS  Google Scholar 

  • Dauthal P, Mukhopadhyay M (2016b) Phyto-synthesis and structural characterization of catalytically active gold nanoparticles biosynthesized using Delonix regia. 3 Biotech 6:1–9

    Article  Google Scholar 

  • Dubey SP, Lahtinen M, Särkkä H, Sillanpää M (2010) Bioprospective of Sorbus aucuparia leaf extract in development of silver and gold nanocolloids. Colloids Surf B Biointerfaces 80:26–33

    Article  PubMed  CAS  Google Scholar 

  • Ebel J, Hahlbrock K (1982) The flavonoids: advances in research by JB Harborne and TJ Marby, chapman and hall. Springer US, London. https://doi.org/10.1007/978-1-4899-2915-0

    Book  Google Scholar 

  • Edison TJI, Sethuraman M (2012) Instant green synthesis of silver nanoparticles using Terminalia chebula fruit extract and evaluation of their catalytic activity on reduction of methylene blue. Process Biochem 47:1351–1357

    Article  CAS  Google Scholar 

  • Edris AE (2007) Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytother Res 21:308–323

    Article  PubMed  CAS  Google Scholar 

  • Emmanuel R, Saravanan M, Ovais M, Padmavathy S, Shinwari ZK, Prakash P (2017) Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from Justicia glauca against oral pathogens: a nanoantibiotic approach. Microb Pathog 113:295–302

    Article  PubMed  CAS  Google Scholar 

  • Ganaie S, Abbasi T, Abbasi S (2016) Rapid and green synthesis of bimetallic Au–Ag nanoparticles using an otherwise worthless weed Antigonon leptopus. J Exp Nanosci 11:395–417

    Article  CAS  Google Scholar 

  • Gavhane AJ, Padmanabhan P, Kamble SP, Jangle SN (2012) Synthesis of silver nanoparticles using extract of neem leaf and triphala and evaluation of their antimicrobial activities. Int J Pharm Bio Sci 3:88–100

    CAS  Google Scholar 

  • Ghoreishi SM, Behpour M, Khayatkashani M (2011) Green synthesis of silver and gold nanoparticles using Rosa damascena and its primary application in electrochemistry. Physica E 44:97–104

    Article  CAS  Google Scholar 

  • González Fá AJ, Juan A, Di Nezio MS (2017) Synthesis and characterization of silver nanoparticles prepared with honey: the role of carbohydrates. Anal Lett 50:877–888

    Article  CAS  Google Scholar 

  • Gopinath K, Kumaraguru S, Bhakyaraj K, Mohan S, Venkatesh KS, Esakkirajan M, Kaleeswarran P, Alharbi NS, Kadaikunnan S, Govindarajan M, Benelli G (2016) Green synthesis of silver, gold and silver/gold bimetallic nanoparticles using the Gloriosa superba leaf extract and their antibacterial and antibiofilm activities. Microb Pathog 101:1–11

    Article  PubMed  CAS  Google Scholar 

  • Harborne JB (2013) The flavonoids: advances in research since 1980. Springer US. ISBN: 978-1-4899-2913-6

  • Jayaseelan C, Rahuman AA (2012) Acaricidal efficacy of synthesized silver nanoparticles using aqueous leaf extract of Ocimum canum against Hyalomma anatolicum and Hyalomma marginatum isaaci (Acari: Ixodidae). Parasitol Res 111:1369–1378

    Article  PubMed  Google Scholar 

  • Jez JM, Bowman ME, Noel JP (2002) Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. Proc Natl Acad Sci 99:5319–5324

    Article  PubMed  CAS  Google Scholar 

  • Jha AK, Prasad K, Prasad K, Kulkarni A (2009) Plant system: nature’s nanofactory. Colloids Surf B Biointerfaces 73:219–223

    Article  PubMed  CAS  Google Scholar 

  • Kanwal U, Irfan Bukhari N, Ovais M, Abass N, Hussain K, Raza A (2017) Advances in nano-delivery systems for doxorubicin: an updated insight. J Drug Target 28:1–15

    Google Scholar 

  • Kasithevar M, Saravanan M, Prakash P, Kumar H, Ovais M, Barabadi H, Shinwari ZK (2017) Green synthesis of silver nanoparticles using Alysicarpus monilifer leaf extract and its antibacterial activity against MRSA and CoNS isolates in HIV patients. J Interdiscip Nanomed 2:131–141

    Article  CAS  Google Scholar 

  • Khalil AT, Ovais M, Ullah I, Ali M, Jan SA, Shinwari ZK, Maaza M (2017a) Bioinspired synthesis of pure massicot phase lead oxide nanoparticles and assessment of their biocompatibility, cytotoxicity and in-vitro biological properties. Arab J Chem. https://doi.org/10.1016/j.arabjc.2017.08.009

  • Khalil AT, Ovais M, Ullah I, Ali M, Shinwari ZK, Hassan D, Maaza M (2017b) Sageretia thea (Osbeck.) modulated biosynthesis of NiO nanoparticles and their in vitro pharmacognostic, antioxidant and cytotoxic potential. Artif Cells Nanomed Biotechnol 46:1–15. https://doi.org/10.1080/21691401.2017.1345928

    Article  CAS  Google Scholar 

  • Khalil AT, Ovais M, Ullah I, Ali M, Shinwari ZK, Khamlich S, Maaza M (2017c) Sageretia thea (Osbeck.) mediated synthesis of zinc oxide nanoparticles and its biological applications. Nanomed 12:1767–1789

    Article  CAS  Google Scholar 

  • Khalil AT, Ovais M, Ullah I, Ali M, Shinwari ZK, Maaza M (2017d) Biosynthesis of iron oxide (Fe2O3) nanoparticles via aqueous extracts of Sageretia Thea (Osbeck.) and their pharmacognostic properties. Green Chem Lett Rev 10:186–201

    Article  CAS  Google Scholar 

  • Khalil AT, Ovais M, Ullah I, Ali M, Shinwari ZK, Maaza M (2017e) Physical properties, biological applications and biocompatibility studies on biosynthesized single phase cobalt oxide (Co3O4) nanoparticles via Sageretia thea (Osbeck.). Arab J Chem. https://doi.org/10.1016/j.arabjc.2017.07.004

  • Khan Z, Hussain JI, Hashmi AA (2012) Shape-directing role of cetyltrimethylammonium bromide in the green synthesis of Ag-nanoparticles using neem (Azadirachta indica) leaf extract. Colloids Surf B Biointerfaces 95:229–234

    Article  PubMed  CAS  Google Scholar 

  • Khan MA, Khan T, Nadhman A (2016) Applications of plant terpenoids in the synthesis of colloidal silver nanoparticles. Adv Colloid Interf Sci 234:132–141

    Article  CAS  Google Scholar 

  • Khan MA, Raza A, Ovais M, Sohail MF, Ali S (2018) Current state and prospects of nano-delivery systems for sorafenib. Int J Polym Mater:1–11. https://doi.org/10.1080/00914037.2018.1429434

  • Kumar KM, Mandal BK, Sinha M, Krishnakumar V (2012) Terminalia chebula mediated green and rapid synthesis of gold nanoparticles. Spectrochim Acta A 86:490–494

    Article  CAS  Google Scholar 

  • Kumari MM, Philip D (2013) Facile one-pot synthesis of gold and silver nanocatalysts using edible coconut oil. Spectrochim Acta A 111:154–160

    Article  CAS  Google Scholar 

  • Lattanzio V, Kroon PA, Quideau S, Treutter D (2008) Plant phenolics—secondary metabolites with diverse functions. Rec Adv Polyphen Res 1:1–35. https://doi.org/10.1002/9781444302400.ch1

    Article  CAS  Google Scholar 

  • Lee J, Kim HY, Zhou H, Hwang S, Koh K, Han D-W, Lee J (2011) Green synthesis of phytochemical-stabilized Au nanoparticles under ambient conditions and their biocompatibility and antioxidative activity. J Mater Chem 21:13316–13326

    Article  CAS  Google Scholar 

  • Li S, Shen Y, Xie A, Yu X, Qiu L, Zhang L, Zhang Q (2007) Green synthesis of silver nanoparticles using Capsicum annuum L. extract. Green Chem 9:852–858

    Article  CAS  Google Scholar 

  • Mahitha B, Raju BD, Dillip GR, Reddy CM, Mallikarjuna K, Manoj L, Priyanka S, Rao KJ, Sushma NJ (2011) Biosynthesis, characterization and antimicrobial studies of AgNPs extract from Bacopa monniera whole plant digest. J Nanomater Biostruct 6:135–142

    Google Scholar 

  • Makarov V, Love A, Sinitsyna O, Makarova S, Yaminsky I, Taliansky M, Kalinina N (2014) “Green” nanotechnologies: synthesis of metal nanoparticles using plants. Acta Nat 6:35–44

    CAS  Google Scholar 

  • Mao H, Liao Y, Ma J, Zhao S, Huo F (2016) Water-soluble metal nanoparticles stabilized by plant polyphenols for improving the catalytic properties in oxidation of alcohols. Nanoscale 8:1049–1054

    Article  PubMed  CAS  Google Scholar 

  • Mares-Briones F, Rosas G (2017) Structure and stability of gold nanoparticles synthesized ssing Schinus molle L. extract. J Clust Sci 28:1995–2003

    Article  CAS  Google Scholar 

  • Mariam AA, Kashif M, Arokiyaraj S, Bououdina M, Sankaracharyulu M, Jayachandran M, Hashim U (2014) Bio-synthesis of NiO and Ni nanoparticles and their characterization. Dig J Nanomater Biostruct 9:1007–1019

    Google Scholar 

  • Mittal AK, Kumar S, Banerjee UC (2014) Quercetin and gallic acid mediated synthesis of bimetallic (silver and selenium) nanoparticles and their antitumor and antimicrobial potential. J Colloid Interface Sci 431:194–199

    Article  PubMed  CAS  Google Scholar 

  • Moulton MC, Braydich-Stolle LK, Nadagouda MN, Kunzelman S, Hussain SM, Varma RS (2010) Synthesis, characterization and biocompatibility of “green” synthesized silver nanoparticles using tea polyphenols. Nanoscale 2:763–770

    Article  PubMed  CAS  Google Scholar 

  • Mukherjee S, Patra CR (2016) Therapeutic application of anti-angiogenic nanomaterials in cancers. Nanoscale 8:12444–12470

    Article  PubMed  CAS  Google Scholar 

  • Mukherjee S, Patra CR (2017) Biologically synthesized metal nanoparticles: recent advancement and future perspectives in cancer theranostics. Future Sci OA. https://doi.org/10.4155/fsoa-2017-0035

  • Mukherjee S, Sushma V, Patra S, Barui AK, Bhadra MP, Sreedhar B, Patra CR (2012) Green chemistry approach for the synthesis and stabilization of biocompatible gold nanoparticles and their potential applications in cancer therapy. Nanotechnology 23:455103. https://doi.org/10.1088/0957-4484/23/45/455103

    Article  PubMed  CAS  Google Scholar 

  • Mukherjee S, Vinothkumar B, Prashanthi S, Bangal PR, Sreedhar B, Patra CR (2013) Potential therapeutic and diagnostic applications of one-step in situ biosynthesized gold nanoconjugates (2-in-1 system) in cancer treatment. RSC Adv 3:2318–2329

    Article  CAS  Google Scholar 

  • Mukherjee S, Chowdhury D, Kotcherlakota R, Patra S (2014) Potential theranostics application of bio-synthesized silver nanoparticles (4-in-1 system). Theranostics 4:316–335

    Article  PubMed  PubMed Central  Google Scholar 

  • Mukherjee S, Dasari M, Priyamvada S, Kotcherlakota R, Bollu VS, Patra CR (2015) A green chemistry approach for the synthesis of gold nanoconjugates that induce the inhibition of cancer cell proliferation through induction of oxidative stress and their in vivo toxicity study. J Mater Chem B 3:3820–3830

    Article  CAS  Google Scholar 

  • Mukherjee S, Sau S, Madhuri D, Bollu VS, Madhusudana K, Sreedhar B, Banerjee R, Patra CR (2016) Green synthesis and characterization of monodispersed gold nanoparticles: toxicity study, delivery of doxorubicin and its bio-distribution in mouse model. J Biomed Nanotechnol 12:165–181

    Article  PubMed  CAS  Google Scholar 

  • Murugan K, Senthilkumar B, Senbagam D, Al-Sohaibani S (2014) Biosynthesis of silver nanoparticles using Acacia leucophloea extract and their antibacterial activity. Int J Nanomedicine 9:2431–2438

    PubMed  PubMed Central  Google Scholar 

  • Nerio LS, Olivero-Verbel J, Stashenko E (2010) Repellent activity of essential oils: a review. Bioresour Technol 101:372–378

    Article  PubMed  CAS  Google Scholar 

  • Ojha AK, Rout J, Behera S, Nayak P (2013) Green synthesis and characterization of zero valent silver nanoparticles from the leaf extract of Datura metel. Int J Pharm Res Allied Sci 2:31–35

    CAS  Google Scholar 

  • Ovais M, Khalil AT, Raza A, Khan MA, Ahmad I, Islam NU, Saravanan M, Ubaid MF, Ali M, Shinwari ZK (2016) Green synthesis of silver nanoparticles via plant extracts: beginning a new era in cancer theranostics. Nanomed 12:3157–3177

    Article  CAS  Google Scholar 

  • Ovais M, Nadhman A, Khalil AT, Raza A, Khuda F, Sohail MF, Islam NU, Sarwar HS, Shahnaz G, Ahmad I, Saravanan M (2017a) Biosynthesized colloidal silver and gold nanoparticles as emerging leishmanicidal agents: an insight. Nanomed 12:2807–2819

    Article  CAS  Google Scholar 

  • Ovais M, Raza A, Naz S, Islam NU, Khalil AT, Ali S, Khan MA, Shinwari ZK (2017b) Current state and prospects of the phytosynthesized colloidal gold nanoparticles and their applications in cancer theranostics. Appl Microbiol Biotechnol 101:3551–3565

    Article  PubMed  CAS  Google Scholar 

  • Ovais M, Ayaz M, Khalil AT, Shah SA, Jan MS, Raza A, Shahid M, Shinwari ZK (2018a) HPLC-DAD finger printing, antioxidant, cholinesterase, and α-glucosidase inhibitory potentials of a novel plant Olax nana. BMC Complement Altern Med 18:1. https://doi.org/10.1186/s12906-017-2057-9

    Article  PubMed  PubMed Central  Google Scholar 

  • Ovais M, Khalil AT, Raza A, Islam NU, Ayaz M, Saravanan M, Ali M, Ahmad I, Shahid M, Shinwari ZK (2018b) Multifunctional theranostic applications of biocompatible green-synthesized colloidal nanoparticles. Appl Microbiol Biotechnol 102:4393–4408

    Article  PubMed  CAS  Google Scholar 

  • Ovais M, Ahmad I, Khalil AT, Mukherjee S, Javed R, Ayaz M, Raza A, Shinwari ZK (2018c) Multifunctional theranostic applications of biocompatible green-synthesized colloidal nanoparticles. Appl Microbiol Biotechnol 102(10):4305–4318

    Article  PubMed  CAS  Google Scholar 

  • Pandey IP, Ahmed SF, Chhimwal S, Pandey S (2012) Chemical composition and wound healing activity of volatile oil of leaves of Azadirachta indica A. juss. Adv Pure Appl Chem 1:2167–0854

    Google Scholar 

  • Parida U, Biswal K, Bindhani B, Nayak P (2013) Green synthesis and characterization of gold nanoparticles using Elettaria cardamomum L. extract. World Appl Sci J 28:962–967

    CAS  Google Scholar 

  • Park Y, Hong Y, Weyers A, Kim Y, Linhardt R (2011) Polysaccharides and phytochemicals: a natural reservoir for the green synthesis of gold and silver nanoparticles. IET Nanobiotechnol 5:69–78

    Article  PubMed  CAS  Google Scholar 

  • Parlinska-Wojtan M, Kus-Liskiewicz M, Depciuch J, Sadik O (2016) Green synthesis and antibacterial effects of aqueous colloidal solutions of silver nanoparticles using camomile terpenoids as a combined reducing and capping agent. Bioprocess Biosyst Eng 39:1213–1223

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Patra CR, Mukherjee S, Kotcherlakota R (2014) Biosynthesized silver nanoparticles: a step forward for cancer theranostics? Nanomed 9:1445–1448

    Article  CAS  Google Scholar 

  • Peddi SP, Sadeh BA (2015) Structural studies of silver nanoparticles obtained through single-step green synthesis. In: IOP Conference Series: Materials Science and Engineering. IOP Publishing Series 92, 012004

  • Philip D (2010) Green synthesis of gold and silver nanoparticles using Hibiscus rosa-sinensis. Physica E 42:1417–1424

    Article  CAS  Google Scholar 

  • Philip D, Unni C (2011) Extracellular biosynthesis of gold and silver nanoparticles using Krishna tulsi (Ocimum sanctum) leaf. Physica E 43:1318–1322

    Article  CAS  Google Scholar 

  • Phillips MA, León P, Boronat A, Rodríguez-Concepción M (2008) The plastidial MEP pathway: unified nomenclature and resources. Trends Plant Sci 13:619–623

    Article  PubMed  CAS  Google Scholar 

  • Pierpoint W (2000) Why do plants make medicines. Biochemist 22:37–40

    CAS  Google Scholar 

  • Poopathi S, De Britto LJ, Praba VL, Mani C, Praveen M (2015) Synthesis of silver nanoparticles from Azadirachta indica—a most effective method for mosquito control. Environ Sci Pollut Res 22:2956–2963

    Article  CAS  Google Scholar 

  • Prathna T, Chandrasekaran N, Raichur AM, Mukherjee A (2011) Kinetic evolution studies of silver nanoparticles in a bio-based green synthesis process. Colloids Surf A Physicochem Eng Asp 377:212–216

    Article  CAS  Google Scholar 

  • Quideau S (2009) Chemistry and biology of ellagitannins: an underestimated class of bioactive plant polyphenols. World Scientific. ISBN: 9812797408

  • Raghunandan D, Basavaraja S, Mahesh B, Balaji S, Manjunath S, Venkataraman A (2009) Biosynthesis of stable polyshaped gold nanoparticles from microwave-exposed aqueous extracellular anti-malignant guava (Psidium guajava) leaf extract. Nanobiotechnology 5:34–41

    Article  CAS  Google Scholar 

  • Raja S, Ramesh V, Thivaharan V (2015) Green biosynthesis of silver nanoparticles using Calliandra haematocephala leaf extract, their antibacterial activity and hydrogen peroxide sensing capability. Arab J Chem 10:253–261

    Article  CAS  Google Scholar 

  • Raveendran P, Fu J, Wallen SL (2003) Completely “green” synthesis and stabilization of metal nanoparticles. J Am Chem Soc 125:13940–13941

    Article  PubMed  CAS  Google Scholar 

  • Safaepour M, Shahverdi AR, Shahverdi HR, Khorramizadeh MR, Gohari AR (2009) Green synthesis of small silver nanoparticles using geraniol and its cytotoxicity against fibrosarcoma-wehi 164. Avicenna J Med Biotechnol1:111–115

  • Sahadevan R, Sivakumar P, Karthika P, Sivakumar Muralidharan N, Devendran P (2013) Biosynthesis of silver nanoparticles from active compounds Quacetin–3-O-B-d-galactopyranoside containing plant extract and its antifungal application. Asian J Pham Clin Res 6:76–79

    Google Scholar 

  • Sahu N, Soni D, Chandrashekhar B, Satpute D, Saravanadevi S, Sarangi B, Pandey R (2016) Synthesis of silver nanoparticles using flavonoids: hesperidin, naringin and diosmin, and their antibacterial effects and cytotoxicity. Int Nano Lett 6:173–181

    Article  Google Scholar 

  • Sankar R, Rizwana K, Shivashangari KS, Ravikumar V (2015) Ultra-rapid photocatalytic activity of Azadirachta indica engineered colloidal titanium dioxide nanoparticles. Appl Nanosci 5:731–736

    Article  CAS  Google Scholar 

  • Sathishkumar M, Sneha K, Won S, Cho C-W, Kim S, Yun Y-S (2009) Cinnamon zeylanicum bark extract and powder mediated green synthesis of nano-crystalline silver particles and its bactericidal activity. Colloids Surf B Biointerfaces 73:332–338

    Article  PubMed  CAS  Google Scholar 

  • Shah M, Fawcett D, Sharma S, Tripathy SK, Poinern GEJ (2015) Green synthesis of metallic nanoparticles via biological entities. Materials 8:7278–7308

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Shankar SS, Ahmad A, Sastry M (2003) Geranium leaf assisted biosynthesis of silver nanoparticles. Biotechnol Prog 19:1627–1631

    Article  PubMed  CAS  Google Scholar 

  • Shankar SS, Rai A, Ahmad A, Sastry M (2004) Rapid synthesis of Au, Ag, and bimetallic Au core–Ag shell nanoparticles using neem (Azadirachta indica) leaf broth. J Colloid Interface Sci 275:496–502

    Article  PubMed  CAS  Google Scholar 

  • Sheny D, Mathew J, Philip D (2012) Synthesis characterization and catalytic action of hexagonal gold nanoparticles using essential oils extracted from Anacardium occidentale. Spectrochim Acta A 97:306–310

    Article  CAS  Google Scholar 

  • Shimada N, Aoki T, Sato S, Nakamura Y, Tabata S, Ayabe S-i (2003) A cluster of genes encodes the two types of chalcone isomerase involved in the biosynthesis of general flavonoids and legume-specific 5-deoxy (iso) flavonoids in Lotus japonicus. Plant Physiol 131:941–951

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Shukla R, Nune SK, Chanda N, Katti K, Mekapothula S, Kulkarni RR, Welshons WV, Kannan R, Katti KV (2008) Soybeans as a phytochemical reservoir for the production and stabilization of biocompatible gold nanoparticles. Small 4:1425–1436

    Article  PubMed  CAS  Google Scholar 

  • Singh AK, Talat M, Singh DP, Srivastava O (2010) Biosynthesis of gold and silver nanoparticles by natural precursor clove and their functionalization with amine group. J Nanopart Res 12:1667–1675

    Article  CAS  Google Scholar 

  • Singhal G, Bhavesh R, Kasariya K, Sharma AR, Singh RP (2011) Biosynthesis of silver nanoparticles using Ocimum sanctum (Tulsi) leaf extract and screening its antimicrobial activity. J Nanopart Res 13:2981–2988

    Article  CAS  Google Scholar 

  • Sinha SN, Paul D (2015) Phytosynthesis of silver nanoparticles using Andrographis paniculata leaf extract and evaluation of their antibacterial activities. Spectrosc Lett 48:600–604

    Article  CAS  Google Scholar 

  • Song JY, Kim BS (2009) Rapid biological synthesis of silver nanoparticles using plant leaf extracts. Bioprocess Biosyst Eng 32:79–84

    Article  PubMed  CAS  Google Scholar 

  • Song JY, Jang H-K, Kim BS (2009) Biological synthesis of gold nanoparticles using Magnolia kobus and Diopyros kaki leaf extracts. Process Biochem 44:1133–1138

    Article  CAS  Google Scholar 

  • Sperling RA, Parak W (2010) Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles. Phil Trans R Soc A 368:1333–1383

    Article  PubMed  CAS  Google Scholar 

  • Stephen A, Seethalakshmi S (2013) Phytochemical synthesis and preliminary characterization of silver nanoparticles using hesperidin. J Nanosci 2013:1–6. https://doi.org/10.1155/2013/126564

    Article  CAS  Google Scholar 

  • Strack D (1997) In: Dey PM, Harborne JB (eds) Plant biochemistry. Academic Press, London ISBN: 978-0-12-214674-9

    Google Scholar 

  • Subbaiya R, Saravanan M, Priya AR, Shankar KR, Selvam M, Ovais M, Balajee R, Barabadi H (2017) Biomimetic synthesis of silver nanoparticles from Streptomyces atrovirens and their potential anticancer activity against human breast cancer cells. IET Nanobiotechnol 11:965–972

    Article  PubMed  Google Scholar 

  • Thakkar KN, Mhatre SS, Parikh RY (2010) Biological synthesis of metallic nanoparticles. Nanomedicine: NBM 6:257–262

    Article  CAS  Google Scholar 

  • Tran TTT, Vu TTH, Nguyen TH (2013) Biosynthesis of silver nanoparticles using Tithonia diversifolia leaf extract and their antimicrobial activity. Mater Lett 105:220–223

    Article  CAS  Google Scholar 

  • Tripathy A, Raichur AM, Chandrasekaran N, Prathna T, Mukherjee A (2010) Process variables in biomimetic synthesis of silver nanoparticles by aqueous extract of Azadirachta indica (neem) leaves. J Nanopart Res 12:237–246

    Article  CAS  Google Scholar 

  • Trouillas P, Marsal P, Siri D, Lazzaroni R, Duroux J-L (2006) A DFT study of the reactivity of OH groups in quercetin and taxifolin antioxidants: the specificity of the 3-OH site. Food Chem 97:679–688

    Article  CAS  Google Scholar 

  • Veitch NC (2010) Flavonoid chemistry of the Leguminosae. In: Santos-Buelga C, Escribano-Bailon MT, Lattanzio V (eds) Recent advances in polyphenol research, Volume 2. Wiley, Oxford. https://doi.org/10.1002/9781444323375.ch2

    Chapter  Google Scholar 

  • Veitch NC, Grayer RJ (2011) Flavonoids and their glycosides, including anthocyanins. Nat Prod Rep 28:1626–1695

    Article  PubMed  CAS  Google Scholar 

  • Vijayaraghavan K, Nalini S (2010) Biotemplates in the green synthesis of silver nanoparticles. Biotechnol J 5:1098–1110

    Article  PubMed  CAS  Google Scholar 

  • Vijayaraghavan K, Nalini SK, Prakash NU, Madhankumar D (2012) One step green synthesis of silver nano/microparticles using extracts of Trachyspermum ammi and Papaver somniferum. Colloids Surf B Biointerfaces 94:114–117

    Article  PubMed  CAS  Google Scholar 

  • Vilas V, Philip D, Mathew J (2014) Catalytically and biologically active silver nanoparticles synthesized using essential oil. Spectrochim Acta A 132:743–750

    Article  CAS  Google Scholar 

  • Wang Z, Fang C, Megharaj M (2014) Characterization of iron–polyphenol nanoparticles synthesized by three plant extracts and their fenton oxidation of azo dye. ACS Sustain Chem Eng 2:1022–1025

    Article  CAS  Google Scholar 

  • Wink M (2010) Introduction: biochemistry, physiology and ecological functions of secondary metabolites. In: Wink M (ed) Annual plant reviews Volume 40: biochemistry of plant secondary metabolism, Second Edition. Wiley-Blackwell, Oxford. https://doi.org/10.1002/9781444320503.ch1

    Chapter  Google Scholar 

  • Winkel-Shirley B (2001) Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. Plant Physiol 126:485–493

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wu S, Chappell J (2008) Metabolic engineering of natural products in plants; tools of the trade and challenges for the future. Curr Opin Biotechnol 19:145–152

    Article  PubMed  CAS  Google Scholar 

  • Yilmaz M, Turkdemir H, Kilic MA, Bayram E, Cicek A, Mete A, Ulug B (2011) Biosynthesis of silver nanoparticles using leaves of Stevia rebaudiana. Mater Chem Phys 130:1195–1202

    Article  CAS  Google Scholar 

  • Yoosaf K, Ipe BI, Suresh CH, Thomas KG (2007) In situ synthesis of metal nanoparticles and selective naked-eye detection of lead ions from aqueous media. J Phys Chem C 111:12839–12847

    Article  CAS  Google Scholar 

  • Yu O, Matsuno M, Subramanian S (2006) Flavonoid compounds in flowers: genetics and biochemistry. In: Teixeira da Silva JA (ed) Floriculture, ornamental and plant biotechnology: advances and topical. Global Science Books, London. https://doi.org/10.1007/s10535-007-0083-z

    Chapter  Google Scholar 

  • Zamiri R, Azmi B, Sadrolhosseini AR, Ahangar HA, Zaidan A, Mahdi M (2011) Preparation of silver nanoparticles in virgin coconut oil using laser ablation. Int J Nanomedicine 6:71–75

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhao X, Xia Y, Li Q, Ma X, Quan F, Geng C, Han Z (2014) Microwave-assisted synthesis of silver nanoparticles using sodium alginate and their antibacterial activity. Colloids Surf A Physicochem Eng Asp 444:180–188

    Article  CAS  Google Scholar 

  • Zhou Y, Lin W, Huang J, Wang W, Gao Y, Lin L, Li Q, Lin L, Du M (2010) Biosynthesis of gold nanoparticles by foliar broths: roles of biocompounds and other attributes of the extracts. Nanoscale Res Lett 5:1351–1359

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zohra T, Ovais M, Khalil AT, Qasim M, Ayaz M, Shinwari ZK (2018) Extraction optimization, total phenolic, flavonoid contents, HPLC-DAD analysis and diverse pharmacological evaluations of Dysphania ambrosioides (L.) Mosyakin & Clemants. Nat Prod Res:12:1–12:7

  • Zwenger S (2008) Plant terpenoids: applications and future potentials. Biotechnol Mol Biol 3:1–7

    Google Scholar 

  • Zygadlo J, Juliani H (2003) Recent progress in medicinal plants phytochemistry and pharmacology II, VIII Studium Press LLC, Texas ISBN : 1930813139

Download references

Author information

Authors and Affiliations

  1. Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 44000, Pakistan

    Muhammad Ovais, Ali Talha Khalil & Zabta Khan Shinwari

  2. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China

    Muhammad Ovais

  3. Department of Eastern Medicine and Surgery, Qarshi University, Lahore, 54000, Pakistan

    Ali Talha Khalil & Zabta Khan Shinwari

  4. Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan

    Nazar Ul Islam

  5. Department of Life sciences, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia

    Irshad Ahmad

  6. Department of Pharmacy, University of Malakand, Chakdara, Khyber Pakhtunkhwa (KPK), 18000, Pakistan

    Muhamamd Ayaz

  7. Department of Medical Microbiology and Immunology, Institute of Biomedical Sciences, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

    Muthupandian Saravanan

  8. Pakistan Academy of Sciences (PAS), Islamabad, Pakistan

    Zabta Khan Shinwari

  9. Department of Bioengineering, Rice University, Houston, TX, USA

    Sudip Mukherjee

Authors
  1. Muhammad Ovais
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ali Talha Khalil
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nazar Ul Islam
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Irshad Ahmad
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Muhamamd Ayaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Muthupandian Saravanan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zabta Khan Shinwari
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sudip Mukherjee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Muhammad Ovais or Sudip Mukherjee.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with animals or human participants performed by any of the authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ovais, M., Khalil, A.T., Islam, N.U. et al. Role of plant phytochemicals and microbial enzymes in biosynthesis of metallic nanoparticles. Appl Microbiol Biotechnol 102, 6799–6814 (2018). https://doi.org/10.1007/s00253-018-9146-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00253-018-9146-7

Keywords

Search

Navigation