Abstract
Flagellar motility in bacteria is a highly regulated and complex cellular process that requires high energy investment for movement and host colonization. Motility plays an important role in the lifestyle of Vibrio spp. in the aquatic environment and during host colonization. Flagellar motility in vibrios is associated with several cellular processes, such as movement, colonization, adhesion, biofilm formation, and virulence. The transcription of all flagella-related genes occurs hierarchically and is regulated positively or negatively by several transcription factors and regulatory proteins. The flagellar regulatory hierarchy is well studied in Vibrio cholerae and Vibrio parahaemolyticus. Here, we compared the regulatory cascade and molecules involved in the flagellar motility of V. cholerae and V. parahaemolyticus in detail. The evolutionary relatedness of the master regulator of the polar and lateral flagella in different Vibrio species is also discussed. Although they can form symbiotic associations of some Vibrio species with humans and aquatic organisms can be harmed by several species of Vibrio as a result of surface contact, characterized by flagellar movement. Thus, targeting flagellar motility in pathogenic Vibrio species is considered a promising approach to control Vibrio infections. This approach, along with the strategies for controlling flagellar motility in different species of Vibrio using naturally derived and chemically synthesized compounds, is discussed in this review.
Key points
• Vibrio species are ubiquitous and distributed across the aquatic environments.
• The flagellar motility is responsible for the chemotactic movement and initial colonization to the host.
• The transition from the motile into the biofilm stage is one of the crucial events in the infection.
• Several signaling pathways are involved in the motility and formation of biofilm.
• Attenuation of motility by naturally derived or chemically synthesized compounds could be a potential treatment for preventing Vibrio biofilm-associated infections.
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This work was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (NRF-2019R1A2C1087156).
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Khan, F., Tabassum, N., Anand, R. et al. Motility of Vibrio spp.: regulation and controlling strategies. Appl Microbiol Biotechnol 104, 8187–8208 (2020). https://doi.org/10.1007/s00253-020-10794-7
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DOI: https://doi.org/10.1007/s00253-020-10794-7