Abstract
Fipronil is a broad-spectrum phenyl-pyrazole insecticide that is widely used in agriculture. However, in the environment, its residues are toxic to aquatic animals, crustaceans, bees, termites, rabbits, lizards, and humans, and it has been classified as a C carcinogen. Due to its residual environmental hazards, various effective approaches, such as adsorption, ozone oxidation, catalyst coupling, inorganic plasma degradation, and microbial degradation, have been developed. Biodegradation is deemed to be the most effective and environmentally friendly method, and several pure cultures of bacteria and fungi capable of degrading fipronil have been isolated and identified, including Streptomyces rochei, Paracoccus sp., Bacillus firmus, Bacillus thuringiensis, Bacillus spp., Stenotrophomonas acidaminiphila, and Aspergillus glaucus. The metabolic reactions of fipronil degradation appear to be the same in different bacteria and are mainly oxidation, reduction, photolysis, and hydrolysis. However, the enzymes and genes responsible for the degradation are somewhat different. The ligninolytic enzyme MnP, the cytochrome P450 enzyme, and esterase play key roles in different strains of bacteria and fungal. Many unanswered questions exist regarding the environmental fate and degradation mechanisms of this pesticide. The genes and enzymes responsible for biodegradation remain largely unexplained, and biomolecular techniques need to be applied in order to gain a comprehensive understanding of these issues. In this review, we summarize the literature on the degradation of fipronil, focusing on biodegradation pathways and identifying the main knowledge gaps that currently exist in order to inform future research.
Key points
• Biodegradation is a powerful tool for the removal of fipronil.
• Oxidation, reduction, photolysis, and hydrolysis play key roles in the degradation of fipronil.
• Possible biochemical pathways of fipronil in the environment are described.
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References
Aajoud A, Ravanel P, Tissut M (2003) Fipronil metabolism and dissipation in a simplified aquatic ecosystem. J Agric Food Chem 51:1347–1352
Abraham J, Gajendiran A (2019) Biodegradation of fipronil and its metabolite fipronil sulfone by Streptomyces rochei strain AJAG7 and its use in bioremediation of contaminated soil. Pestic Biochem Phys 155:90–100
Ahmad J, Naeem S, Ahmad M, Usman ARA, Al-Wabel MI (2019) A critical review on organic micropollutants contamination in wastewater and removal through carbon nanotubes. J Environ Manage 246:214–228
Al-Badran AA, Fujiwara M, Mora MA (2019) Effects of insecticides, fipronil and imidacloprid, on the growth, survival, and behavior of brown shrimp Farfantepenaeus aztecus. PLoS ONE 14:e223641
Anagnostopoulos C, Ampadogiannis G, Bempelou E, Liapis K, Kastellanou E (2020) The 2017 fipronil egg contamination incident: the case of Greece. J Food Saf 40(1)
Anandan S, Wu JJ (2015) Effective degradation of fipronil using combined catalytic ozonation processes. Ozone Sci Eng 37:186–190
Arora PK, Srivastava A, Garg SK, Singh VP (2018) Recent advances in degradation of chloronitrophenols. Bioresour Technol 250:902–909
At K, Karthikeyan S, Thanga SGV (2019) Occurrence and microbial degradation of fipronil residues in tropical highland rhizosphere soils of Kerala. India Soil Sediment Contam 28:360–379
Bhatt P, Rene ER, Kumar AJ, Zhang WP, Chen S (2020) Binding interaction of allethrin with esterase: bioremediation potential and mechanism. Bioresour Technol 315:123845
Bhatt P, Rene ER, Kumar AJ, Gangola S, Kumar G, Sharma A, Chen S (2021a) Fipronil degradation kinetics and resource recovery potential of Bacillus sp. strain FA4 isolated from a contaminated agricultural field in Uttarakhand, India. Chemosphere 276:130156
Bhatt P, Sharma A, Rene ER, Kumar AJ, Zhang W, Chen S (2021b) Bioremediation of fipronil using Bacillus sp. FA3: mechanism, kinetics and resource recovery potential from contaminated environments. J Water Process Eng 39:101712
Bhatt P, Bhatt K, Sharma A, Zhang W, Mishra S, Chen S (2021c) Biotechnological basis of microbial consortia for the removal of pesticides from the environment. Crit Rev Biotechnol 41:32
Bhatt P, Zhou X, Huang Y, Zhang W, Chen S (2021d) Characterization of the role of esterases in the biodegradation of organophosphate, carbamate, and pyrethroid pesticides. J Hazard Mater 411: 125026
Birolli WG, Lima RN, Porto ALM (2019) Applications of marine-derived microorganisms and their enzymes in biocatalysis and biotransformation, the underexplored potentials. Front Microbiol 10:1453
Bobe A, Meallier P, Cooper JF, Coste CM (1998) Kinetics and mechanisms of abiotic degradation of fipronil (hydrolysis and photolysis). J Agric Food Chem 46:2834–2839
Bonmatin JM, Giorio C, Girolami V, Goulson D, Kreutzweiser DP, Krupke C, Liess M, Long E, Marzaro M, Mitchell EAD, Noome DA, Simon-Delso N, Tapparo A (2014) Environmental fate and exposure; neonicotinoids and fipronil. Environ Sci Pollut Res 22:35–67
Caboni P, Sammelson RE, Casida JE (2003) Phenylpyrazole insecticide photochemistry, metabolism, and GABAergic action: ethiprole compared with fipronil. J Agric Food Chem 51:7055–7061
Cappelini LTD, Alberice JV, Eugenio PFM, Pozzi E, Urbaczek AC, Diniz LGR, Carrilho ENVM, Carrilho E, Vieira EM (2018) Burkholderia thailandensis: the main bacteria biodegrading fipronil in fertilized soil with assessment by a QuEChERS/GC-MS method. J Brazil Chem Soc 29:1934–1943
Carrao DB, Habenchus MD, Perez De Albuquerque NC, Da Silva RM, Lopes NP, Moraes De Oliveira AR (2019) In vitro inhibition of human CYP2D6 by the chiral pesticide fipronil and its metabolite fipronil sulfone: prediction of pesticide-drug interactions. Toxicol Lett 313:196–204
Casida JE, Durkin KA (2013) Neuroactive insecticides: targets, selectivity, resistance, and secondary effects. Annu. Rev. Entomol, Vol 58, ed. M.R. Berenbaum, 99–117
Cerniglia CE (1997) Fungal metabolism of polycyclic aromatic hydrocarbons: past, present and future applications in bioremediation. J Ind Microbiol Biotechnol 19:324–333
Chen FR, Xie GX, Yu HY, Peng D, Yu M, Huang HL, Zeng GM (2008) Development of lignin-biodegrading inoculant for composting. J Ecol Rural Environ 24:84–87
Chen S, Chang C, Deng Y, An S, Dong YH, Zhou J, Hu M (2014) Fenpropathrin biodegradation pathway in Bacillus sp. DG-02 and its potential for bioremediation of pyrethroid-contaminated soils. J Agric Food Chem 62:2147–2157
Chen S, Hu Q, Hu M, Luo J, Weng Q, Lai K (2011) Isolation and characterization of a fungus able to degrade pyrethroids and 3-phenoxybenzaldehyde. Bioresour Technol 102: 8110–8116
Cheng L, Lu Y, Zhao Z, Hoogenboom RLAP, Zhang Q, Liu X (2020) Assessing the combined toxicity effects of three neonicotinoid pesticide mixtures on human neuroblastoma SK-N-SH and lepidopteran Sf-9 cells. Food Chem Toxicol 145:111631
Chigure GM, Sharma AK, Kumar S, Fular A, Sagar SV, Nagar G (2018) Role of metabolic enzymes in conferring resistance to synthetic pyrethroids, organophosphates, and phenylpyrazole compounds in Rhipicephalus microplus. Int J Acarol 44:28–34
Cryder Z, Wolf D, Carlan C, Gan J (2021) Removal of urban-use insecticides in a large-scale constructed wetland. Environ Pollut 268:115586
Cycoń M, Mrozik A, Piotrowska-Seget Z (2017) Bioaugmentation as a strategy for the remediation of pesticide-polluted soil: a review. Chemosphere 172:52–71
Feng Y, Huang Y, Zhan H, Bhatt P, Chen S (2020) An overview of strobilurin fungicide degradation: current status and future perspective. Front Microbiol 11:389
Fenet H, Beltran E, Gadji B, Cooper JF, Coste CM (2001) Fate of a phenylpyrazole in vegetation and soil under tropical field conditions. J Agric Food Chem 49:1293–1297
Gajendiran A, Abraham J (2017) Biomineralisation of fipronil and its major metabolite, fipronil sulfone, by Aspergillus glaucus strain AJAG1 with enzymes studies and bioformulation. 3 Biotech 7:212
Gao C, Chen Y, Dong Y, Su J (2014) Mechanism of fipronil resistance in Laodelphax striatellus (Hemiptera: Delphacidae). J Entomol Sci 49:1–10
Ghaffar A, Hussain R, Abbas G, Kalim M, Khan A, Ferrando S (2018) Fipronil (Phenylpyrazole) induces hemato-biochemical, histological and genetic damage at low doses in common carp, Cyprinus carpio (Linnaeus, 1758). Ecotoxicology 27:1261–1271
Ghosh S, Azhahianambi P, Yadav MP (2007) Upcoming and future strategies of tick control: a review. J Vector Dis 44:79–89
Gibbons D, Morrissey C, Mineau P (2016) A review of the direct and indirect effects of neonicotinoids and fipronil on vertebrate wildlife (2015). Environ Sci Pollut Res 23:947–947
Goff AD, Saranjampour P, Ryana LM, Hladik ML, Covi JA, Armbrust KL (2017) The effects of fipronil and the photodegradation product fipronil desulfinyl on growth and gene expression in juvenile blue crabs, Callinectes sapidus, at different salinities. Aquat Toxicol 186:96–104
Gomes Junior O, Borges Neto W, Machado AEH, Daniel D, Trovo AG (2017) Optimization of fipronil degradation by heterogeneous photocatalysis: Identification of transformation products and toxicity assessment. Water Res 110:133–140
Gondhalekar AD, Scharf ME (2012) Mechanisms underlying fipronil resistance in a multiresistant field strain of the German Cockroach (Blattodea: Blattellidae). J Med Entomol 49:122–131
Gunasekara AS, Truong T, Goh KS, Spurlock F, Tjeerdema RS (2007) Environmental fate and toxicology of fipronil. J Pestic Sci 32:189–199
Hainzl D, Cole LM, Casida JE (1998) Mechanisms for selective toxicity of fipronil insecticide and its sulfone metabolite and desulfinyl photoproduct. Chem Res Toxicol 11:1529–1535
Han C, Hu BZ, Li Z, Liu CQ, Wang N, Fu CC, Shen Y (2020) Determination of fipronil and four metabolites in foodstuffs of animal origin using a modified QuEChERS method and GC-NCI-MS/MS. Food Anal Method 14:237–249
Hu Y, Bai Y, Yu H, Zhang C, Chen J (2013) Degradation of selected organophosphate pesticides in wastewater by dielectric barrier discharge plasma. B Environ Contam Toxicol 91:314–319
Huang Y, Lin Z, Zhang W, Pang S, Bhatt P, Rene ER, Kumar AJ, Chen S (2020) New insights into the microbial degradation of D-cyphenothrin in contaminated water/soil environments. Microorganisms 8:473
Ikehata K, El-Din MG (2005) Aqueous pesticide degradation by ozonation and ozone-based advanced oxidation processes: a review (Part I). Ozone-Sci Eng 27:83–114
Jiang X, Yang S, Yan Y, Lin F, Zhang L, Zhao W (2020) Design, synthesis, and insecticidal activity of 5,5-disubstituted 4,5-dihydropyrazolo 1,5-a quinazolines as novel antagonists of GABA receptors. J Agric Food Chem 68:15005–15014
Jin Y, Gao Y, Zhang H, Wang L, Yang K, Dong H (2020) Detoxification enzymes associated with butene-fipronil resistance in Epacromius coerulipes. Pest Manag Sci 76:227–235
Kumar R, Singh B, Gupta VK (2012) Biodegradation of fipronil by Paracoccus sp. in different types of soil. B Environ Contam Toxicol 88:781–787
Lao W (2021) Fiproles as a proxy for ecological risk assessment of mixture of fipronil and its degradates in effluent-dominated surface waters. Water Res 188:116510
Lewis KA, Tzilivakis J, Warner DJ, Green A (2016) An international database for pesticide risk assessments and management. Hum Ecol Risk Assess 22:1050–1064
Li SP, Jiang YY, Cao XH, Dong YW, Dong M, Xu J (2013) Degradation of nitenpyram pesticide in aqueous solution by low-temperature plasma. Environ Technol 34:1609–1616
Lin Z, Pang S, Zhang W, Mishra S, Bhatt P, Chen S (2020) Degradation of acephate and its intermediate methamidophos: mechanisms and biochemical pathways. Front Microbiol 11:2045
Lin Z, Pang S, Zhou Z, Wu X, Bhatt P, Chen S (2021) Current insights into the microbial degradation for butachlor: strains, metabolic pathways, and molecular mechanisms. Appl Microbiol Biotechnol 105:4369–4381
Liu X, Liang M, Liu Y, Fan X (2017) Directed evolution and secretory expression of a pyrethroid-hydrolyzing esterase with enhanced catalytic activity and thermostability. Microb Cell Fact 16:81
Luo Y, Guo W, Ngo HH, Long Duc N, Hai FI, Zhang J (2014) A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment. Sci Total Environ 473:619–641
Mandal K, Singh B, Jariyal M, Gupta VK (2013) Microbial degradation of fipronil by Bacillus thuringiensis. Ecotoxicol Environ Saf 93:87–92
Mandal K, Singh B, Jariyal M, Gupta VK (2014) Bioremediation of fipronil by a Bacillus firmus isolate from soil. Chemosphere 101:55–60
Masutti CSM, Mermut AR (2007a) Degradation of fipronil under laboratory conditions in a tropical soil from sirinhaem pernambuco. Brazil J Environ Sci Health B 42:33–43
Masutti CSM, Mermut AR (2007b) Sorption of fipronil and its sulfide derivative by soils and goethite. Geoderma 140:1–7
Mcmahen RL, Strynar MJ, Mcmillan L, Derose E, Lindstrom AB (2016) Comparison of fipronil sources in North Carolina surface water and identification of a novel fipronil transformation product in recycled wastewater. Sci Total Environ 569:880–887
Mishra S, Zhang WP, Lin ZQ, Pang SM, Huang YH, Bhatt P (2020) Carbofuran toxicity and its microbial degradation in contaminated environments. Chemosphere 259:127429
Mohapatra S, Deepa M, Jagdish GK, Rashmi N, Kumar S, Prakash GS (2010) Fate of fipronil and its metabolites in/on grape leaves, berries and soil under semi arid tropical climatic conditions. B Environ Contam Toxicol 84:587–591
Monard C, Martin-Laurent F, Lima O, Devers-Lamrani M, Binet F (2013) Estimating the biodegradation of pesticide in soils by monitoring pesticide-degrading gene expression. Biodegradation 24:203–213
Mukherjee I (2006) Sorption of fipronil in tropical soils. B Environ Contam Toxicol 76:334–340
Mulrooney JE (2002) Efficacy of fipronil aerially applied in oil adjuvants and drift retardants against boll weevils, Anthonomus grandis Boheman (Coleoptera: Curculionidae). Southwest Entomol 27:201–207
Mulvey J, Cresswell JE (2020) Time-dependent effects on bumble bees of dietary exposures to farmland insecticides (imidacloprid, thiamethoxam and fipronil). Pest Manag Sci 76:2843–2853
Ngim KK, Mabury SA, Crosby DG (2000) Elucidation of fipronil photodegradation pathways. J Agric Food Chem 48:4661–4665
Ngim KK, Crosby DG (2001) Abiotic processes influencing fipronil and desthiofipronil dissipation in California, USA, rice fields. Environ Toxicol Chem
Paliwal R, Uniyal S, Verma M, Kumar A, Rai JPN (2016) Process optimization for biodegradation of black liquor by immobilized novel bacterial consortium. Desalin Water Treat 57:18915–18926
Pang S, Lin Z, Zhang W, Mishra S, Bhatt P, Chen S (2020) Insights into the microbial degradation and biochemical mechanisms of neonicotinoids. Front Microbiol 11:868
Pinedo-Rivilla C, Aleu J, Collado IG (2009) Pollutants biodegradation by fungi. Curr Org Chem 13:1194–1214
Pisa LW, Amaral-Rogers V, Belzunces LP, Bonmatin JM, Downs CA, Goulson D, Kreutzweiser DP, Krupke C, Liess M, Mcfield M, Morrissey CA, Noome DA, Settele J, Simon-Delso N, Stark JD, Van Der Sluijs JP, Van Dyck H, Wiemers M (2015) Effects of neonicotinoids and fipronil on non-target invertebrates. Environ Sci Pollut R 22:68–102
Pizzul L, Castillo MDP, Stenstrom J (2009) Degradation of glyphosate and other pesticides by ligninolytic enzymes. Biodegradation 20:751–759
Pointing SB, Vrijmoed LLP (2000) Decolorization of azo and triphenylmethane dyes by Pycnoporus sanguineus producing laccase as the sole phenoloxidase. World J Microbiol Biotechnol 16:317–318
Prada-Vasquez MA, Estrada-Florez SE, Serna-Galvis EA, Torres-Palma RA (2021) Developments in the intensification of photo-Fenton and ozonation-based processes for the removal of contaminants of emerging concern in Ibero-American countries. Sci Total Environ 765:142699–142699
Prakasham RS, Rao CS, Rao RS, Rajesham S, Sarma PN (2005) Optimization of alkaline protease production by Bacillus sp. using Taguchi methodology. Appl Biochem Biotech 120:133–144
Qian C, Dai J, Tian Y, Duan Y, Li Y (2020) Efficient degradation of fipronil in water by microwave-induced argon plasma: mechanism and degradation pathways. Sci Total Environ 725:138487
Qin F, Gao Y, Xu P, Guo B, Li J, Wang H (2015) Enantioselective bioaccumulation and toxic effects of fipronil in the earthworm Eisenia foetida following soil exposure. Pest Manag Sci 71:553–561
Qu H, Ma RX, Liu DH, Gao J, Wang F, Zhou ZQ, Wang P (2016) Environmental behavior of the chiral insecticide fipronil: enantioselective toxicity, distribution and transformation in aquatic ecosystem. Water Res 105:138–146
Ramasubramanian T, Paramasivam M (2017) Determination and dissipation of fipronil and its metabolites in/on sugarcane crop. Int J Environ an Ch 97:1037–1052
Raveton M, Aajoud A, Willison JC, Aouadi H, Tissut M, Ravanel P (2006) Phototransformation of the insecticide fipronil: identification of novel photoproducts and evidence for an alternative pathway of photodegradation. Environ Sci Technol 40:4151–4157
Saini S, Rani M, Kumari B (2014) Persistence of fipronil and its metabolites in soil under field conditions. Environ Monit Assess 186:69–75
Shi L, Chen L, Wan Y, Zeng H, Xia W (2020a) Spatial variation of fipronil and its derivatives in tap water and ground water from China and the fate of them during drinking water treatment in Wuhan, central China. Chemosphere 251:126385
Shi L, Jiang Y, Wan Y, Huang J, Meng Q, He Z, Xu S, Xia W (2020b) Occurrence of the insecticide fipronil and its degradates in indoor dust from South, Central, and North China. Sci Total Environ 741:140110
Shuai X, Chen J, Ray C (2012) Adsorption, transport and degradation of fipronil termiticide in three Hawaii soils. Pest Manag Sci 68:731–739
Simon-Delso N, Amaral-Rogers V, Belzunces LP, Bonmatin JM, Chagnon M, Downs C (2015) Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites. Environ Sci Pollut Res 22:5–34
Stevens MM, Helliwell S, Warren GN (1998) Fipronil seed treatments for the control of chironomid larvae (Diptera: Chironomidae) in aerially-sown rice crops. Field Crops Res 57:195–207
Tan H, Cao Y, Tang T, Qian K, Chen WL, Li J (2008) Biodegradation and chiral stability of fipronil in aerobic and flooded paddy soils. Sci Total Environ 407:428–437
Tian Y, Gao Y, Chen Y, Liu G, Ju X (2019) Identification of the fipronil resistance associated mutations in nilaparvata lugens GABA receptors by molecular modeling. Molecules 24:4116
Tingle CCD, Rother JA, Dewhurst CF, Lauer S, King WJ (2003) Fipronil: environmental fate, ecotoxicology, and human health concerns. in Rev Environ Contam Toxicol ed. GW Ware, 176:1–66
Uniyal S, Paliwal R, Sharma RK, Rai JPN (2016) Degradation of fipronil by Stenotrophomonas acidaminiphila isolated from rhizospheric soil of Zea mays. 3 Biotech 6:48
Wan Y, Tri Manh T, Vinh Thi N, Wang A, Wang J, Kannan K (2021) Neonicotinoids, fipronil, chlorpyrifos, carbendazim, chlorotriazines, chlorophenoxy herbicides, bentazon, and selected pesticide transformation products in surface water and drinking water from northern Vietnam. Sci Total Environ 750:141507
Wang TC, Lu N, Li J, Wu Y (2010a) Degradation of pentachlorophenol in soil by pulsed corona discharge plasma. J Hazard Mater 180:436–441
Wang TC, Lu N, Li J, Wu Y (2010b) Evaluation of the potential of pentachlorophenol degradation in soil by pulsed corona discharge plasma from soil characteristics. Environ Sci Technol 44:3105–3110
Wang X, Martínez MA, Wu Q, Ares I, Martínez-Larrañaga MR, Anadón A, Yuan Z (2016) Fipronil insecticide toxicology: oxidative stress and metabolism. Crit Rev Toxicol 46:876–899
Wang S, Li H, You J (2019) Enantioselective degradation and bioaccumulation of sediment-associated fipronil in Lumbriculus variegatus: toxicokinetic analysis. Sci Total Environ 672:335–341
Weston DP, Lydy MJ (2014) Toxicity of the insecticide fipronil and its degradates to benthic macroinvertebrates of urban streams. Environ Sci Technol 48:1290–1297
Wolfand JM, Lefevre GH, Luthy RG (2016) Metabolization and degradation kinetics of the urban-use pesticide fipronil by white rot fungus Trametes versicolor. Environ Sci Proc Imp 18:1256–1265
Yang J, Feng Y, Zhan H, Liu J, Yang F, Zhang K, Zhang L, Chen S (2018) Characterization of a pyrethroid-degrading Pseudomonas fulva strain P31 and biochemical degradation pathway of D-phenothrin. Front Microbiol 9:1003
Yin M, Ma T, Zhang J, Huang M, Ma B (2006) The effect of high-pressure arc discharge plasma on the degradation of chlorpyrifos. Plasma Sci Technol 8:727–731
Ying GG, Kookana RS (2001) Sorption of fipronil and its metabolites on soils from South Australia. J Environ Sci Health, Part B 36:545–558
Ying GG, Kookana R (2002) Laboratory and field studies on the degradation of fipronil in a soil. Aust J Soil Res 40:1095–1102
Zhan H, Feng Y, Fan X, Chen S (2018) Recent advances in glyphosate biodegradation. Appl Microbiol Biotechnol 102: 5033–5043
Zhang W, Lin Z, Pang S, Bhatt P, Chen S (2020) Insights into the biodegradation of lindane (γ-hexachlorocyclohexane) using a microbial system. Front Microbiol 11: 522
Zhang Q, Zhang L, Li Z, Zhang L, Li D (2019) Enhancement of fipronil degradation with eliminating its toxicity in a microbial fuel cell and the catabolic versatility of anodic biofilm. Bioresour Technol 290:121723
Zhang Y, Zhang W, Li J, Pang S, Mishra S, Bhatt P, Zeng D, Chen S (2021) Emerging technologies for degradation of dichlorvos: a review. Int J Environ Res Public Health 18:5789
Zhou P, Lu YT, Liu BF, Gan JJ (2004) Dynamics of fipronil residue in vegetable-field ecosystem. Chemosphere 57:1691–1696
Zhu GN, Wu HM, Guo JF, Kimaro FME (2004) Microbial degradation of fipronil in clay loam soil. Water Air Soil Pollut 153:35–44
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We acknowledge the grants from the Key-Area Research and Development Program of Guangdong Province, China (2018B020206001, 2020B0202090001), the Natural Science Foundation of Guangdong Province (2021A1515010889), and Guangdong Special Support Program (2017TQ04N026).
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SC conceived of the presented idea. ZZ contributed to the writing and prepared the figures and tables. XW, ZL, SP, SM, and SC participated in revising the manuscript. All authors approved it for publication.
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Zhou, Z., Wu, X., Lin, Z. et al. Biodegradation of fipronil: current state of mechanisms of biodegradation and future perspectives. Appl Microbiol Biotechnol 105, 7695–7708 (2021). https://doi.org/10.1007/s00253-021-11605-3
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DOI: https://doi.org/10.1007/s00253-021-11605-3