Abstract
Carotid artery stenting has been proposed as an option treatment of carotid artery stenosis. The aim of this single-institution study is to compare the dual-antiplatelet treatment and heparin combined with acetyl-acetic acid, in patients who underwent carotid artery stenting. We compared 2 groups of 50 patents each who underwent carotid artery stenting for primary atherosclerotic disease. Group A received heparin for 24 h combined with 325 mg acetyl-acetic acid and group B received 250 mg ticlopidine twice a day combined with 325 mg acetyl-acetic acid. Outcome measurements included 30-day bleeding and neurological complications and 30-day thrombosis/occlusion rates. The neurological complications were 16% in group A and 2% in group B (p < 0.05). Bleeding complications occurred in 4% in group A and 2% in group B (p > 0.05). The 30-day thrombosis/occlusion rate was 2% in group A and 0% in group B (p > 0.05). Dual antiplatelet treatment is recommended in all patients undergoing carotid artery stenting.
Similar content being viewed by others
References
SchÖmig A, Neumann FJ, Kastrati A, et al. (1996) A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med 334:1084–1089
Hall P, Nakamura S, Maiello L, et al. (1996) A randomized comparison of combined ticlopidine and aspirin therapy versus aspirin therapy alone after successful intra-vascular ultrasound-guided stent implantation. Circulation. 93:215–222
Leon MB, Baim DS, Pompa JJ, et al. (1998) A clinical trial comparing three antithrombotic-drug regiments after coronary-artery stenting. N Engl J Med 339:1665–1671
Steinhubl SR, Ellis SG, Wolski K, et al. (2001) Ticlopidine pretreatment before coronary stenting is associated with substained decrease in adverse cardiac events: data from the Evaluation of Platelet iib/iiia inhibitor for stenting (EPISTENT) Trial. Circulation 103:1403–1409
McKevitt FM, Randall MS, Cleveland TJ, et al. (2005) The benefits of combined anti-platelet treatment in the carotid artery stenting. Eur J Vasc Endovasc Surg 29:522–527
North American Symptomatic Carotid Endarterectomy Trial Collaborators. (1991) Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 325:445–453
Berger PB (2000) Results of the ticlid or plavix post-stents (TOPPS) trial: Do they justify the switch from ticlopidine to clopidrogrel after coronary stent placement? Curr Control Trials Cardiovasc Med 1:83–87
Maleux G, Bernaerts P, Thijs V, et al. (2003) Extracranial carotid artery stenting in surgically high-risk patients using the Carotid Wallstent endoprosthesis: Midterm clinical and ultrasound follow-up results. Cardiovasc Intervent Radiol 26:340–346
Knight CJ, Panesar M, Wilson DJ, et al. (1998) Increased platelet responsiveness following coronary stenting. Heparin as a possible aetiological factor in stent thrombosis. Eur Heart J 19:1239–1248
Grewe PH, Deneke T, Machraoui Am Barmeyer J, et al. (2000) Acute and chronic tissue response to coronary stent implantation: Pathologic findings in human specimen. J Am Coll Cardiol 35:157–163
Yip H-K, Liou C-W, Chang H-W, et al. (2005) Link between Platelet Activity and Outcomes after an Ischemic Stroke. Cerebrovasc Dis 20:120–128
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dalainas, I., Nano, G., Bianchi, P. et al. Dual Antiplatelet Regime Versus Acetyl-acetic Acid for Carotid Artery Stenting. Cardiovasc Intervent Radiol 29, 519–521 (2006). https://doi.org/10.1007/s00270-005-5288-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00270-005-5288-y