Optimized Synthesis of Salicylate-based Poly( anhydride-esters)

Summary

The synthesis of a salicylate-based poly(anhydride-ester) was optimized to improve the overall efficiency and quality of the polymer. First, a new approach for the preparation of the polymer precursor minimizes the overall number of synthetic steps and increases the overall yield. Second, the melt-polymerization apparatus was modified to include dynamic mixing, which yields polymer with increased molecular weights on both the milligram and gram scale.