Summary
One of the main routes of peptide and protein delivery is parenteral. The need for daily or repetitive injection of these parenteral formulations is the main cause of patient non-compliance. The objective of this study was to prepare a controlled delivery system for peptide and proteins to increase patient compliance. Biodegradable triblock copolymers of PLGA and PEG (PLGA-PEG-PLGA) were synthesized and characterized using various content of glycolide. Solutions of PLGA-PEG-PLGA containing calcitonin as a model peptide were prepared and drug release from the sol-gel systems was evaluated in two different incubation conditions. Zero order release kinetics was achieved for up to 100 hours. No significant burst release effect was observed. It seemed that surface gelation was the main cause of drug release control. The release data fitted to Higuchi’s modeling and showed good correlation. It can be concluded that in situ gelling system prepared in this study can be used for a weekly peptide delivery system.
Similar content being viewed by others
References
Dinarvand R, Dorkoosh F, Hamidi M, Moghadam SH. (2004) Biotechnol Genet Eng Rev 21, 147
Sun YU, Lee HJ, Almon RR and Jusko WJ. (1999) J Pharmacol Exper Therap 289, 1523
Cohen S, Yoshioka T, Lucarelli M, Hwang LH and Langer R. (1991) Pharm Res 8, 713
Capan Y, Jiang G, Giovagnoli S, Na KH and DeLuca PP. (2003) AAPS PharmSciTech 4
Chen S, Pieper R, Webster DC and Singh J. (2005) Int J Pharm 288, 207
Soppimath KS, Aminabhavi TM, Dave AM, Kumbar SG and Rudzinski WE. (2002) Drug Dev Ind Pharm 28, 957
Eeckman F, Moes AJ and Amighi K. (2004) Eur Polymer J 40, 873
Dinarvand R and Ansari M. (2002) Daru 10, 105
Malmsten M and Lindman B. (1992) Macromolecules 25, 5440
Qiao M, Chen D, Ma X and Liu Y. (2005) Int J Pharm 294, 103
USP DI, Drug Information for the Health Care Professional. (1999), Micromedex
Jeong B, Bae YH, Lee DS and Kim SW. (1997) Nature 388, 860
Zentner GM, Rathi R, Shih C, McRea JC, Seo MH, Oh H, Rhee BG, Mestecky J, Moldoveanu Z, Morgan M and Weitman S. (2001) J Controlled Rel 72, 203
Jeong B, Han Bae Y and Wan Kim S. (1999) Colloids and Surfaces B: Biointerfaces 16, 185
Kim R. M, Park G. T. (2001) J Controlled Rel 80, 71
Chen S, Singh J. (2005) Int J Pharm 295, 185
British Pharmacopoeia. (2004), The Stationery Office
Venkatraman SS, Jie P, Min F, Freddy BYC and Leong-Huat G. (2005) Int J Pharm 298, 219
Van De Weert M, Van ’T Hof R, Van Der Weerd J, Heeren RMA, Posthuma G, Hennink WE and Crommelin DJA. (2000) J Controlled Rel 68, 31
Packhaeuser CB, Schnieders J, Oster CG and Kissel T. (2004) Eur J Pharm Biopharm 58, 445
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ghahremankhani, A., Dorkoosh, F. & Dinarvand, R. PLGA-PEG-PLGA tri-block copolymers as an in-situ gel forming system for calcitonin delivery. Polym. Bull. 59, 637–646 (2007). https://doi.org/10.1007/s00289-007-0807-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00289-007-0807-4