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Syntheses and properties of novel copolymers of polycaprolactone and aliphatic polycarbonate based on ketal-protected dihydroxyacetone

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Abstract

The random copolymers of ε-caprolactone (CL) and 2,2-ethylenedioxy propane-1,3-diol carbonate (EOPDC) were synthesized in bulk at 120 °C using Sn(Oct)2 as a catalyst. The poly(EOPDC-co–CL)s obtained were characterized by FT IR, 1H NMR, 13C NMR, GPC and DSC. The copolymers were obtained with yield of 84.2–97.8 %. The number-average molecular weight of the copolymer is 2.75–7.76 × 104 with a polydispersity of 1.52–1.68. The properties of the copolymer including the enzymatic degradation by Pseudomonas Cepacia lipase and drug-controlled release property were also investigated. The results showed that the copolymers are degradable at physiological conditions, and their degradation rate and release of Tegafur in the copolymers increase with increasing CL content in the copolymers.

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Acknowledgments

The authors are grateful for the financial support of national key basic research and development program (G1999064703) and natural science foundation of China (Grant No. 20174029).

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Authors and Affiliations

  1. School of Chemistry and Materials Science, Hubei Engineering University, Xiaogan, 432000, Hubei, China

    Lian-sheng Wang

  2. Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, Hubei, China

    Lian-sheng Wang, Si-xue Cheng & Ren-xi Zhuo

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  1. Lian-sheng Wang
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  2. Si-xue Cheng
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Correspondence to Lian-sheng Wang or Ren-xi Zhuo.

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Wang, Ls., Cheng, Sx. & Zhuo, Rx. Syntheses and properties of novel copolymers of polycaprolactone and aliphatic polycarbonate based on ketal-protected dihydroxyacetone. Polym. Bull. 71, 47–56 (2014). https://doi.org/10.1007/s00289-013-1044-7

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  • DOI: https://doi.org/10.1007/s00289-013-1044-7

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