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Interpenetrating polymer network as a pioneer drug delivery system: a review

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Abstract

Interpenetrating polymer network (IPN) is an enterprising drug delivery system, comprising of two polymers with several advantages like stability, biocompatibility, high swelling capacity and biodegradability which plays an important function in targeted and controlled drug delivery. IPN acquired appreciable focus in the pharmaceutical sector mostly for the last few decades because of their utility in biomedical applications like tissue engineering and drug delivery at the target site at desired rate. For the past few years, different types of polymers obtained from natural or artificial sources have been used to prepare the IPN, resulting in improved properties; thus, IPN is considered in the category of the novel technologies demonstrating the superior performances as compared to the conventional technique. IPN development leads to the formation of dosage form with reduced side effects and prolonged drug action. The current topic includes IPN, types of IPN, mode of preparation, applications, delivery systems and list of polymers employed in the synthesis of IPN.

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Abbreviations

IPN:

Interpenetrating polymer network

IPNs:

Interpenetrating polymer networks

SIPN:

Semi-IPN

LBG:

Locust bean gum

CTG:

Carboxy tamarind gum

GMP:

Good manufacturing practices

IPN-NPs:

IPN nanoparticles

SCMC:

Sodium carboxymethyl cellulose

PVA:

Polyvinyl acetate

PEG:

Polyethylene glycol

HA:

Hyaluronic acid

ESR:

Electron spin resonance

NMR:

Nuclear magnetic resonance

TGA:

Thermogravimetric analysis

DSC:

Differential scanning calorimetry

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Authors and Affiliations

  1. Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, Sector-3, M.B Road, New Delhi, 110017, India

    Neha Raina, Radha Rani, Azmi Khan & Madhu Gupta

  2. Amity Institute of Pharmacy, Amity University, Noida, UP, 201303, India

    Kalpana Nagpal

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  1. Neha Raina
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Raina, N., Rani, R., Khan, A. et al. Interpenetrating polymer network as a pioneer drug delivery system: a review. Polym. Bull. 77, 5027–5050 (2020). https://doi.org/10.1007/s00289-019-02996-5

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