Skip to main content
SpringerLink
Log in

Synthesis and characterization of chitosan nanoparticles containing teicoplanin using sol–gel

  • Original Paper
  • Published:
Polymer Bulletin Aims and scope Submit manuscript

Abstract

Chitosan, as a natural polysaccharide, has a unique structure and multi-functional properties. One of the most prominent specifications of chitosan is high biocompatibility, good biodegradability, low toxicity and antibacterial and antiallergenicity properties. Chitosan has a high potential for controlled drug delivery. Therefore, investigating the loading capacity and release rate of chitosan at different conditions is important. By reducing particle size, chitosan has shown a high ability of teicoplanin loading due to its cationic property, which is important in this research. The aim of this study was to investigate chitosan nanoparticle potential for use in biomedical devices for drug delivery systems. Nanoparticles were prepared by ionic gelation with tripolyphosphate (TPP) ion, and the factors that affected chitosan nanoparticle size were investigated. The prepared samples were characterized using DLS, FTIR, TGA, DSC and XRD techniques. It is found at best condition with CS/TPP ratio of 2:1 nanoparticles were obtained at an average size of about 100 nm. The results confirmed that the drug (teicoplanin) loaded on the TPP cross-linked chitosan nanoparticles causes an increase in nanochitosan size and there was no interaction between teicoplanin and chitosan. Also, it is observed that 28.2% of teicoplanin was released in the first 10 h and the release is continued gradually to receive 37.4% in 100 h. Thus, it seems that chitosan nanoparticles mitigate the drug release and are suitable for sustained drug release.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12

Similar content being viewed by others

References

  1. Piras AM, Maisetta G, Sandreschi S, Gazzarri M, Bartoli C, Grassi L, Esin S, Chiellini F, Batoni G (2015) Chitosan nanoparticles loaded with the antimicrobial peptide temporin B exert along-term antibacterial activity in vitro against clinical isolates of Staphylococcus epidermidis. Front Microbiol. https://doi.org/10.3389/fmicb.2015.00372

    Article  PubMed  PubMed Central  Google Scholar 

  2. Harris M, Alexander C, Wells CM, Bumgardner JD, Carpenter DP, Jennings JA (2017) Chitosan for the delivery of antibiotics. In: Jennings JA, Bumgardner JD (eds) Chitosan based biomaterials, vol 2. Elsevier, New York, pp 147–173

    Chapter  Google Scholar 

  3. Dustgania A, Vasheghani Farahania E, Imani M (2008) Preparation of chitosan nanoparticles loaded by dexamethasone sodium phosphate. Iran J Pharm Sci 4(2):111–114

    Google Scholar 

  4. Ibrahim HM, El-Bisi MK, Taha GM, El-Alfy EA (2015) Chitosan nanoparticles loaded antibiotics as drug delivery biomaterial. J Appl Pharm Sci 5(10):085–090

    Article  CAS  Google Scholar 

  5. Porras-Gómez M, Vega-Baudrit J, Núñez-Corrales S (2018) Ampicillin-loaded chitosan nanoparticles for in vitro antimicrobial screening on Escherichia coli. In: Dongre R (ed) Chitin–chitosan—myriad functionalities in science and technology. IntechOpen, London, pp 245–259

    Google Scholar 

  6. Duttagupta DS, Jadhav VM, Kadam VJ (2015) Chitosan: a propitious biopolymer for drug delivery. Curr Drug Deliv 12(4):369–381

    Article  CAS  Google Scholar 

  7. Chattopadhyay D, Inamdar M (2013) Improvement in properties of cotton fabric through synthesized nano-chitosan application. Indian J Fibre Text Res 38:14–21

    CAS  Google Scholar 

  8. Uskoković V, Desai TA (2014) In vitro analysis of nanoparticulate hydroxyapatite/chitosan composites as potential drug delivery platforms for the sustained release of antibiotics in the treatment of osteomyelitis. J Pharm Sci 103:567–579

    Article  Google Scholar 

  9. Landriscina A, Rosen J, Friedman AJ (2015) Biodegradable chitosan nanoparticles in drug delivery for infectious disease. Nanomedicine 10(10):1609–1619

    Article  CAS  Google Scholar 

  10. Li N, Zhuang CY, Wang M, Sun XY, Nie SF, Pan WS (2009) Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery. Int J Pharm 379:131–138

    Article  CAS  Google Scholar 

  11. Dash M, Chiellini F, Ottenbrite R, Chiellini E (2011) Chitosan—a versatile semi-synthetic polymer in biomedical applications. Prog Polym Sci 36:981–1014

    Article  CAS  Google Scholar 

  12. Jimtaisong A, Saewan N (2014) Utilization of carboxymethyl chitosan in cosmetics. Int J Cosmetic Sci 36(1):12–21

    Article  CAS  Google Scholar 

  13. El-Sherbiny IM, El-Baz NM (2015) A review on bionanocomposites based on chitosan and its derivatives for biomedical applications. In: Thakur VK, Thakur MK (eds) Eco-friendly polymer nanocomposites: chemistry and applications. Elsevier, New York, pp 74–173

    Google Scholar 

  14. Liu H, Gao C (2009) Preparation and properties of ionically cross-linked chitosan nanoparticles. Polym Adv Technol 20(7):613–619

    Article  CAS  Google Scholar 

  15. Patra JK, Das G, Fraceto LF, Ramos Campos EV, Rodriguez-Torres MP, Acosta- Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, Habtemariam S, Shin H-S (2018) Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol. https://doi.org/10.1186/s12951-018-0392-8

    Article  Google Scholar 

  16. Jahangirian H, Lemraski EG, Webster TJ, Rafiee-Moghaddam R, Abdollahi Y (2017) A review of drug delivery systems based on nanotechnology and green chemistry, green nanomedicine. Int J Nanomed 12:2957

    Article  CAS  Google Scholar 

  17. Chifiriuc MC, Holban AM, Curutiu C, Ditu L-M, Mihaescu G, Oprea AE, Grumezescu AM, Lazar V (2016) Antibiotic drug delivery systems for the intracellular targeting of bacterial pathogens. In: Sezer AD (ed) Smart drug delivery system. InTech, London, pp 305–344

    Google Scholar 

  18. Buschmann MD, Merzouki A, Lavertu M, Thibault M, Jean M, Darras V (2013) Chitosans for delivery of nucleic acids. Adv Drug Deliv Rev 65:1234–1270

    Article  CAS  Google Scholar 

  19. Romainor ANB, Chin SF, Pang SC, Bilung LM (2014) Preparation and characterization of chitosan nanoparticles-doped cellulose films with antimicrobial property. J Nanomater. https://doi.org/10.1155/2014/710459

    Article  Google Scholar 

  20. Soares PIP, Sousa AI, Silva JC, Ferreira IMM, Novo CMM, Borges JP (2016) Chitosan-based nanoparticles as drug delivery systems for doxorubicin: optimization and modelling. Carbohydr Polym 147:304–312

    Article  CAS  Google Scholar 

  21. Safhi MM, Sivakumar SM, Jabeen A, Zakir F, Islam F, Bagul US, Sanobar S, Anwer T, Siddiqui R, Siddiqui MAH, Elmobark ME, Barik BB, Alam MF (2016) Therapeutic potential of chitosan nanoparticles as antibiotic delivery system: challenges to treat multiple drug resistance. Asian J Pharm 10(2):S62

    Google Scholar 

  22. Movaffagh J, Ghodsi A, Fazly Bazzaz BS, Sajadi Tabassi SA, Ghodrati Azadi H (2013) The use of natural biopolymer of chitosan as biodegradable beads for local antibiotic delivery: release studies. Jundishapur J Nat Pharm Prod 8(1):27–33

    Article  Google Scholar 

  23. Geng X, Kwon OH, Jang J (2005) Electrospining of chitosan dissolved in concentrated acetic acid solution. Biomaterials 26:5427–5432

    Article  CAS  Google Scholar 

  24. Bhumkar DR, Pokharkar VB (2006) Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: a technical note. AAPS Pharm Sci Tech 7(2):E1–E6

    Article  Google Scholar 

  25. Wan Y, Creber KAM, Peppley B, Bui VT (2003) Synthesis, characterization and ionic conductive properties of phosphorylated chitosan membranes. Macromol Chem Phys 204:850–858

    Article  CAS  Google Scholar 

  26. Ravi Kumar MNV (2000) A review of chitin and chitosan applications. React Funct Polym 46(1):1–27

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Amirkabir University of Technology, Tehran, Iran

    Shafiq Ahmad Kahdestani & Majid Abdouss

  2. Department of Chemistry, Education Faculty of Herat University, Herat, Afghanistan

    Shafiq Ahmad Kahdestani

  3. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

    Mehrnoosh Hasan Shahriari

Authors
  1. Shafiq Ahmad Kahdestani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mehrnoosh Hasan Shahriari
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Majid Abdouss
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Majid Abdouss.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kahdestani, S.A., Shahriari, M.H. & Abdouss, M. Synthesis and characterization of chitosan nanoparticles containing teicoplanin using sol–gel. Polym. Bull. 78, 1133–1148 (2021). https://doi.org/10.1007/s00289-020-03134-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00289-020-03134-2

Keywords

Search

Navigation