Abstract
The eight Millennium Development Goals (MDGs) are international development targets for the year 2015 that aim to achieve relative improvements in the standards of health, socioeconomic status and education in the world’s poorest countries. Many of the challenges addressed by the MDGs reflect the direct or indirect consequences of subsistence agriculture in the developing world, and hence, plant biotechnology has an important role to play in helping to achieve MDG targets. In this opinion article, we discuss each of the MDGs in turn, provide examples to show how plant biotechnology may be able to accelerate progress towards the stated MDG objectives, and offer our opinion on the likelihood of such technology being implemented. In combination with other strategies, plant biotechnology can make a contribution towards sustainable development in the future although the extent to which progress can be made in today’s political climate depends on how we deal with current barriers to adoption.
Similar content being viewed by others
References
Akobundu IO (1991) Weeds in human affairs is sub-Saharan Africa. Weed Tech 5:680–690
APCoAB (Asia-Pacific Consortium on Agricultural Biotechnology) (2006) Bt cotton in India: a status report. ICRASTAT, New Delhi
Balga P (2010) After acrimonious debate, India rejects GM eggplant. Science 327:767
Bhatnagar-Mathur P, Vadez V, Sharma KK (2008) Transgenic approaches for abiotic stress tolerance in plants: retrospect and prospects. Plant Cell Rep 27:411–424
Bourguet D (2004) Resistance to Bacillus thuringiensis toxins in the European corn borer: what chance for Bt maize? Physiol Entomol 29:251–256
Brookes G (2008) The benefits of adopting GM insect resistant (Bt) maize in the EU: first results from 1998–2006. Int J Biotechnol 10:148–166
Brookes G, Barfoot P (2010) GM crops: global socio-economic and environmental impacts 1996–2008. PG Economics Ltd, Dorchester
Castiglioni P, Warner D, Bensen RJ, Anstrom DC, Harrison J, Stoecker M, Abad M, Kumar G, Salvador S, D’Ordine R, Navarro S, Back S, Fernandes M, Targolli J, Dasgupta S, Bonin C, Luethy MH, Heard JE (2008) Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited conditions. Plant Physiol 147:446–455
Christou P, Twyman RM (2004) Potential of genetically engineered crops to address food insecurity. Nutr Res Rev 17:23–42
Christou P, Capell T, Kohli A, Gatehouse JA, Gatehouse AM (2006) Recent developments and future prospects in insect pest control in transgenic crops. Trends Plant Sci 11:302–308
DFID (2010) The politics of poverty: elites, citizens and states. Findings from ten years of DFID-funded research on governance and fragile states 2001–2010. DFID, London, UK
Ejeta G, Rich PJ, Mohamed A (2007) Dissecting a complex trait to simpler components for effective breeding of sorghum with a high level of Striga resistance. In: Ejeta G, Gressel J (eds) Integrating new technologies for Striga control—towards ending the witch hunt. World Scientific, Singapore, pp 87–98
Elías-López AL, Marquina B, Gutiérrez-Ortega A, Aguilar D, Gomez-Lim M, Hernández-Pando R (2008) Transgenic tomato expressing interleukin-12 has a therapeutic effect in a murine model of progressive pulmonary tuberculosis. Clin Exp Immunol 154:123–133
Fan S, Chan-Kang C, Mukherjee A (2005) Rural and urban dynamics and poverty: evidence from China and India. International Food Policy Research Institute, Washington, DC
FAO (2009a) Maize, rice and wheat: area harvested production quantity yield. FAO, Rome
FAO (2009b) The state of food insecurity in the world 2009. Economic crises—impacts and lessons learned. FAO, Rome
Farre G, Ramessar K, Twyman RM, Capell T, Christou P (2009) The humanitarian impact of plant biotechnology: recent breakthroughs vs bottlenecks for adoption. Curr Opin Plant Biol 13:219–225
Farre G, Twyman RM, Bai C, Zhu C, Capell T, Christou P (2010) Nutritionally enhanced crops and food security: scientific achievements versus political expediency. Curr Opin Biotechnol 22:1–7
Floss DM, Sack M, Arcalis E, Stadlmann J, Quendler H, Rademacher T, Stoger E, Scheller J, Fischer R, Conrad U (2009) Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody. Plant Biotechnol J 7:899–913
Floss DM, Mockey M, Zanello G, Brosson D, Diogon M, Frutos R, Bruel T, Rodrigues V, Garzon E, Chevaleyre C, Berri M, Salmon H, Conrad U, Dedieu L (2010) Expression and immunogenicity of the mycobacterial Ag85B/ESAT-6 antigens produced in transgenic plants by elastin-like peptide fusion strategy. J Biomed Biotechnol 2010:274346
Freedman LP, Waldman RJ, De Pinho H, Wirth ME, Chowdhury AMR, Rosenfield A (2005) UN Millennium Project. Who’s got the power? Transforming health systems for women and children Task force on child health and maternal health. Earthscan, London, UK
Gealy DR (2005) Gene movement between rice (Oryza sativa) and weedy rice (Oryza sativa)—a US temperate rice perspective. In: Gressel J (ed) Crop ferality and volunteerism. CRC, Boca Raton, pp 323–354
Gómez-Galera S, Rojas E, Sudhakar D, Zhu C, Pelacho AM, Capell T, Christou P (2010) Critical evaluation of strategies for mineral fortification of staple food crops. Transgenic Res 19:165–180
Gressel J (2009) Biotech and gender issues in developing world. Nat Biotechnol 27:1085–1086
Gressel J, Valverde BE (2009) The other, ignored HIV—highly invasive vegetation. Food Security 1:463–478
Gressel J, Hanafi A, Head G, Marasas W, Obilana AB, Ochanda J, Souissi T, Tzotzos G (2004) Major heretofore intractable biotic constraints to African food security that may be amenable to novel biotechnological solutions. Crop Protection 23:661–689
Hearne SJ (2009) Control—the Striga conundrum. Pest Manage Sci 65:603–614
Hogan MC, Foreman KJ, Naghavi M, Ahn SY, Wang M, Makela SM, Lopez AD, Lozano R, Murray CJ (2010) Maternal mortality for 181 countries, 1980–2008: a systematic analysis of progress towards Millennium Development Goal 5. Lancet 375:1609–1623
Islam N (2008) Reducing poverty and hunger in Asia. The role of agricultural and rural development. International Food Policy Research Institute (IFPRI), Washington, DC
James C (2010) Global status of commercialized biotech/GM crops: 2009. ISAAA Brief 41-2009. ISAAA, Ithaca, NY
Jayaraman K (2010) Bt brinjal splits Indian cabinet. Nat Biotechnol 28:296
Kanampiu FK, Ranson JK, Gressel J, Jewell D, Friesen D, Grimanelli D, Hoisington D (2002) Appropriateness of biotechnology to African agriculture: Striga and maize as paradigms. Plant Cell Tissue Organ Cult 69:105–110
Karihaloo JL, Kumar AP (2009) Bt cotton in India: a status report, 2nd edn. APCoAB/APAARI, New Delhi
Ma JKC, Drake PMW, Christou P (2003) The production of recombinant pharmaceutical proteins in plants. Nat Rev Genet 4:794–805
Ma C, Wang H, Lu X, Wang H, Xu G, Liu B (2009) Terpenoid metabolic profiling analysis of transgenic Artemisia annua L. by comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry. Metabolomics 5:497–506
Manjunath T (2008) Bt cotton in India: remarkable adoption and benefits. Foundation for Biotech Awareness and Education, India
Mataruka D, Marechera G, Omanya G, Wachoro G, Mignouna HJD, Ng’ang’a L, Adam ME, Muchiri N, Obokoh N, Oikeh S (2010) Closer to the promise: from lab to field. Annual report 2009. African Agricultural Technology Foundation, Africa
Miller JD, Marasas WFO (2002) Ecology of mycotoxins in maize and groundnuts. Low Extern Input Sustain Agric 2002(Suppl):23–24
Monsanto (2010) Press release, 5th March 2010. Available on-line at: http://www.monsanto.com/newsviews/Pages/india-pink-bollworm.aspx
Morris J, Hawthorne KM, Hotze T, Abrams SA, Hirschi KD (2008) Nutritional impact of elevated calcium transport activity in carrots. Proc Natl Acad Sci USA 105:1431–1435
Naqvi S, Zhu C, Farre G, Ramessar K, Bassie L, Breitenbach J, Perez D, Ros G, Sandmann G, Capell T, Christou P (2009) Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways. Proc Natl Acad Sci USA 106:7762–7767
Naranjo SE (2009) Impacts of Bt crops on non-target invertebrates and insecticide use patterns. CAB Rev 4:11
Nelson DE, Repetti PP, Adams TR, Creelman RA, Wu J, Warner DC, Anstrom DC, Bensen RJ, Castiglioni PP, Donnarummo MG, Hinchey BS, Kumimoto RW, Maszle DR, Canales RD, Krolikowski KA, Dotson SB, Gutterson N, Ratcliffe OJ, Heard JE (2007) Plant nuclear factor Y (NF-Y) B subunits confer drought tolerance and lead to improved corn yields on water-limited acres. Proc Natl Acad Sci USA 104:16450–16455
Nochi T, Takagi H, Yuki Y, Yang L, Masumura T, Mejima M, Nakanishi U, Matsumura A, Uozumi A, Hiroi T, Morita S, Tanaka K, Takaiwa F, Kiyono H (2007) Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination. Proc Natl Acad Sci USA 104:10986–10991
O’Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, Mirsalis J, d’Andrea A, Hume SD, Bratcher B, Saucedo CJ, McMahon JB, Pogue GP, Palmer KE (2009) Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component. Proc Natl Acad Sci USA 106:6099–6104
Padian N, Quan J, Gould H, Glass S (1998) Choice of female-controlled methods of barrier contraceptives among young women and their male partners in northern California diminishes over time. Int Conf AIDS 12:616
Paine JA, Shipton CA, Chaggar S, Howells RM, Kennedy MJ, Vernon G, Wright SY, Hinchliffe E, Adams JL, Silverstone AL, Drake R (2005) Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nat Biotechnol 23:482–487
Park S, Elless MP, Park J, Jenkins A, Lim W, Chambers E, Hirschi KD (2009) Sensory analysis of calcium-biofortified lettuce. Plant Biotechnol J 7:106–117
Parker C (2009) Observations on the current status of Orobanche and Striga problems worldwide. Pest Manage Sci 65:453–459
Paul M, Ma JK (2010) Plant-made immunogens and effective delivery strategies. Expert Rev Vaccines 9:821–833
Population Council (2000) The female condom: dynamics of use in urban Zimbabwe. Population Council Horizons Project, Washington, DC
Potrykus I (2010) Regulation must be revolutionized. Nature 466:561
Qaim M, Subramanian A, Gopal Naik G, Zilberman D (2006) Adoption of Bt cotton and impact variability: insights from India. Rev Agric Econ 28:59–71
Rademacher T, Sack M, Arcalis E, Stadlmann J, Balzer S, Altmann F, Quendler H, Stiegler G, Kunert R, Fischer R, Stoger E (2008) Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans. Plant Biotechnol J 6:189–201
Ramessar K, Capell T, Christou P (2008a) Molecular pharming in cereal crops. Phytochem Rev 7:579–592
Ramessar K, Rademacher T, Sack M, Stadlmann J, Platis D, Stiegler G, Labrou N, Altmann F, Ma J, Stöger E, Capell T, Christou P (2008b) Cost-effective production of a vaginal protein microbicide to prevent HIV transmission. Proc Natl Acad Sci USA 105:3727–3732
Ramessar K, Sabalza M, Capell T, Christou P (2008c) Maize plants: an ideal production platform for effective and safe molecular pharming. Plant Sci 174:409–419
Ramessar K, Sabalza M, Miralpeix B, Capell T, Christou P (2010) Can microbicides turn the tide against HIV? Curr Pharm Des 16:468–485
Rigano MM, Alvarez ML, Pinkhasov J, Jin Y, Sala F, Arntzen CJ, Walmsley AM (2004) Production of a fusion protein consisting of the enterotoxigenic Escherichia coli heat-labile toxin B subunit and a tuberculosis antigen in Arabidopsis thaliana. Plant Cell Rep 7:502–508
Sachs JD, McArthur JW (2005) The Millennium Project: a plan for meeting the Millennium Development Goals. Lancet 365:347–353
Sanahuja G, Banakar R, Twyman RM, Capell T, Christou P (2011) A century of Bt and it’s still going strong. Plant Biotechnol J (in press)
Sanchez PA (2009) A smarter way to combat hunger. Nature 458:148
Sanchis V, Bourguet D (2008) Bacillus thuringiensis: applications in agriculture and insect resistance management. A review. Agron Sustain Dev 28:11–20
Sexton A, Drake PM, Mahmood N, Harman SJ, Shattock RJ, Ma JK-C (2006) Transgenic plant production of Cyanovirin-N, an HIV microbicide. FASEB J 20:356–358
Sexton A, Harman S, Shattock RJ, Ma JK-C (2009) Design, expression, and characterization of a multivalent, combination HIV microbicide. FASEB J 23:3590–3600
Spok A, Twyman RM, Fischer R, Ma JKC, Sparrow PAC (2008) Evolution of a regulatory framework for plant-made pharmaceuticals. Trends Biotechnol 26:506–517
Storozhenko S, De Brouwer V, Volckaert M, Navarrete O, Blancquaert D, Zhang GF, Lambert W, Van Der Straeten D (2007) Folate fortification of rice by metabolic engineering. Nat Biotechnol 25:1277–1279
Strasser R, Castilho A, Stadlmann J, Kunert R, Quendler H, Gattinger P, Jez J, Rademacher T, Altmann F, Mach L, Steinkellner H (2009) Improved virus neutralization by plant-produced anti-HIV antibodies with a homogeneous beta1, 4-galactosylated N-glycan profile. J Biol Chem 284:20479–20485
Subramaniam A, Qaim M (2010) The impact of Bt cotton on poor households in rural India. J Dev Sci 46:295–311
Subramanian A, Kirwan K, Pink D, Qaim M (2010) GM crops and gender issues. Nat Biotechnol 28:404–405
Tacket CO, Mason HS, Losonsky G, Clements JD, Levine MM, Arntzen CJ (1998) Immunogenicity in humans of a recombinant bacterial-antigen delivered in transgenic potato. Nat Med 4:607–609
Tacket CO, Mason HS, Losonsky G, Estes MK, Levine MM, Arntzen CJ (2000) Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J Infect Dis 182:302–305
Tiwari S, Verma PC, Singh PK, Tuli R (2009) Plants as bioreactors for the production of vaccine antigens. Biotechnol Adv 27:449–467
Twyman RM, Schillberg S, Fischer R (2005) Transgenic plants in the biopharmaceutical market. Expert Opin Emerg Drugs 10:185–218
UNAIDS (2008) Report on the global HIV/AIDS epidemic 2008. Joint United Nations Programme on HIV/AIDS (UNAIDS), Geneva, Switzerland
UNAIDS/WHO (2009) AIDS epidemic update: November 2009. Joint United Nations Programme on HIV/AIDS (UNAIDS) and World Health Organization, Geneva, Switzerland
UNICEF (2006) Vitamin A deficiency. http://www.childinfo.org/areas/vitamina/
UNICEF (2010) Measles and polio immunization campaign targets 20 million children in Bangladesh. http://www.unicef.org/infobycountry/bangladesh_52966.html
United Nations (2009) The Millennium Development Goals Report 2009. United Nations Department of Economic and Social Affairs (DESA), NY
United Nations (2010a) The Millennium Development Goals Report 2010. United Nations Department of Economic and Social Affairs (DESA), NY
United Nations (2010b) The MDG Monitor. United Nations Development Program and United Nations Department of Economic and Social Affairs (DESA), NY. http://www.mdgmonitor.org
Valverde BE (2005) The damage by weedy rice—can feral rice remain undetected? In: Gressel J (ed) Crop ferality and volunteerism. CRC, Boca Raton, pp 279–294
Valverde BE, Itoh K (2001) Herbicide resistance and its management in world rice ecosystems. In: Powles SB, Shaner DL (eds) Herbicide resistance and world grains. CRC, Boca Raton, pp 195–249
Virk P, Barry G (2009) Biofortified rice—towards combating human micronutrient deficiencies. In: 14th Australasian Plant Breeding and 11th SABRAO Conference, Cairns, Queensland, Australia, 10–14 Aug 2009. http://km.fao.org/gipb/images/pdf_files/LiteratureViews/Virk_DOC_apb09.pdf
Williams JH, Grubb JA, Davis JW, Wang JS, Jolly PE, Ankrah NA, Ellis WO, Afriyie-Gyawu E, Johnson NM, Robinson AG, Phillips TD (2010) HIV and hepatocellular and esophageal carcinomas related to consumption of mycotoxin-prone foods in sub-Saharan Africa. Am J Clin Nutr 92:154–160
Wirth J, Poletti S, Aeschlimann B, Yakandawala N, Drosse B, Osorio S, Tohge T, Fernie AR, Günther D, Gruissem W, Sautter C (2009) Rice endosperm iron biofortification by targeted and synergistic action of nicotianamine synthase and ferritin. Plant Biotechnol J 7:1–14
Wu F (2007) Bt corn and impact on mycotoxins. CAB Rev 2:60
Ye X, Al-Babili S, Klöti A, Zhang J, Lucca P, Beyer P, Potrykus I (2000) Engineering the provitamin A (β-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 287:303–305
Yorobe J (2004) Economics impact of Bt corn in the Philippines. Paper presented to the 45th PAEDA convention, Querzon City
Yusibov V, Rabindran S (2008) Recent progress in the development of plant derived vaccines. Expert Rev Vaccines 7:1173–1183
Zeigler R (2009) After China, Philippines may approve GMO rice. Reuters. http://uk.reuters.com/article/idUSTRE62F0T720100316
Zhu C, Naqvi S, Breitenbach J, Sandmann G, Christou P, Capell T (2008) Reconstruction and extension of the carotenoid biosynthetic pathway in maize through combinatorial nuclear genetic transformation. Proc Natl Acad Sci USA 105:18232–18237
Acknowledgments
Research in our laboratory is supported by Ministry of Science and Innovation-MICINN, Spain (Grant BFU2007-61413); European Research Council Advanced Grant BIOFORCE; Center Consolider, MICINN, Spain; COST Action FA0804, Associated Unit CAVA and SmartCell, FP7 Integrated project.
Author information
Authors and Affiliations
Corresponding author
Additional information
Communicated by R. Reski.
A contribution to the Special Issue: Plant Biotechnology in Support of the Millennium Development Goals.
Appendix 1: The Millennium Development Goals in full (UN 2010a)
Appendix 1: The Millennium Development Goals in full (UN 2010a)
-
Goal 1: Eradicate extreme poverty and hunger
-
Target 1A: Halve the proportion of people living on less than $1 a day
-
Target 1B: Achieve decent employment for women, men, and young people
-
Target 1C: Halve the proportion of people who suffer from hunger
-
-
Goal 2: Achieve universal primary education
-
Target 2A: By 2015, all children can complete a full course of primary schooling, girls and boys
-
-
Goal 3: Promote gender equality and empower women
-
Target 3A: Eliminate gender disparity in primary and secondary education preferably by 2005 and at all levels by 2015
-
-
Goal 4: Reduce child mortality rate
-
Target 4A: Reduce by two-thirds, between 1990 and 2015, the under-five mortality rate
-
-
Goal 5: Improve maternal health
-
Target 5A: Reduce by three quarters, between 1990 and 2015, the maternal mortality ratio
-
Target 5B: Achieve, by 2015, universal access to reproductive health
-
-
Goal 6: Combat HIV/AIDS, malaria, and other diseases
-
Target 6A: Have halted by 2015 and begun to reverse the spread of HIV/AIDS
-
Target 6B: Achieve, by 2010, universal access to treatment for HIV/AIDS for all those who need it
-
Target 6C: Have halted by 2015 and begun to reverse the incidence of malaria and other major diseases
-
-
Goal 7: Ensure environmental sustainability
-
Target 7A: Integrate the principles of sustainable development into country policies and programs, and reverse loss of environmental resources
-
Target 7B: Reduce biodiversity loss, achieving, by 2010, a significant reduction in the rate of loss
-
Target 7C: Halve, by 2015, the proportion of people without sustainable access to safe drinking water and basic sanitation
-
Target 7D: By 2020, to have achieved a significant improvement in the lives of at least 100 million slum-dwellers
-
-
Goal 8: Develop a global partnership for development
-
Target 8A: Develop further an open, rule-based, predictable, non-discriminatory trading and financial system
-
Target 8B: Address the special needs of the least developed countries (LDC)
-
Target 8C: Address the special needs of landlocked developing countries and small island developing states
-
Target 8D: Deal comprehensively with the debt problems of developing countries through national and international measures in order to make debt sustainable in the long term
-
Target 8E: In co-operation with pharmaceutical companies, provide access to affordable, essential drugs in developing countries
-
Target 8F: In co-operation with the private sector, make available the benefits of new technologies, especially information and communications
-
Rights and permissions
About this article
Cite this article
Yuan, D., Bassie, L., Sabalza, M. et al. The potential impact of plant biotechnology on the Millennium Development Goals. Plant Cell Rep 30, 249–265 (2011). https://doi.org/10.1007/s00299-010-0987-5
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00299-010-0987-5