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Predicting ventriculoperitoneal shunt infection in children with hydrocephalus using artificial neural network

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Abstract

Objectives

The relationships between shunt infection and predictive factors have not been previously investigated using Artificial Neural Network (ANN) model. The aim of this study was to develop an ANN model to predict shunt infection in a group of children with shunted hydrocephalus.

Materials and methods

Among more than 800 ventriculoperitoneal shunt procedures which had been performed between April 2000 and April 2011, 68 patients with shunt infection and 80 controls that fulfilled a set of meticulous inclusion/exclusion criteria were consecutively enrolled. Univariate analysis was performed for a long list of risk factors, and those with p value < 0.2 were used to create ANN and logistic regression (LR) models.

Results

Five variables including birth weight, age at the first shunting, shunt revision, prematurity, and myelomeningocele were significantly associated with shunt infection via univariate analysis, and two other variables (intraventricular hemorrhage and coincided infections) had a p value of less than 0.2. Using these seven input variables, ANN and LR models predicted shunt infection with an accuracy of 83.1 % (AUC; 91.98 %, 95 % CI) and 55.7 % (AUC; 76.5, 95 % CI), respectively. The contribution of the factors in the predictive performance of ANN in descending order was history of shunt revision, low birth weight (under 2000 g), history of prematurity, the age at the first shunt procedure, history of intraventricular hemorrhage, history of myelomeningocele, and coinfection.

Conclusion

The findings show that artificial neural networks can predict shunt infection with a high level of accuracy in children with shunted hydrocephalus. Also, the contribution of different risk factors in the prediction of shunt infection can be determined using the trained network.

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Authors and Affiliations

  1. Department of Neurosurgery, Children’s Hospital Medical Center, Tehran University of Medical Science, Gharib street, Tehran, 141557854, Iran

    Zohreh Habibi, Mohammad Sadegh Nikdad, Atefeh Sadat Mirmohseni, Mohsen Afarideh, Vahid Heidari & Farideh Nejat

  2. Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Science, Tehran, Iran

    Abolhasan Ertiaei, Hooshang Saberi & Abdolreza Sheikh Rezaei

Authors
  1. Zohreh Habibi
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  2. Abolhasan Ertiaei
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  3. Mohammad Sadegh Nikdad
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  4. Atefeh Sadat Mirmohseni
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  5. Mohsen Afarideh
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  6. Vahid Heidari
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  8. Abdolreza Sheikh Rezaei
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  9. Farideh Nejat
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Correspondence to Farideh Nejat.

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Habibi, Z., Ertiaei, A., Nikdad, M.S. et al. Predicting ventriculoperitoneal shunt infection in children with hydrocephalus using artificial neural network. Childs Nerv Syst 32, 2143–2151 (2016). https://doi.org/10.1007/s00381-016-3248-2

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  • DOI: https://doi.org/10.1007/s00381-016-3248-2

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