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Structural properties of nonionic surfactant/glycerol/paraffin lyotropic liquid crystals

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Abstract

Lamellar lyotropic liquid-crystalline systems are thermodynamically stable, optically isotropic and are formed spontaneously. New possibilities for the development of controlled drug delivery systems are inherent in these systems in consequence of their stability and special, skin-friendly structure. The aim was to formulate and study two-component or multicomponent compositions with a relatively low Brij 96V content, liquid paraffin, glycerol and water for therapeutic purposes. The liquid crystals were examined by polarizing light microscopy and transmission electron microscopic observation of replicas produced by the freeze–fracture technique to demonstrate the presence of lamellar liquid-crystalline domains. The existence of a regular structure was determined by X-ray diffraction.

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Acknowledgements

The authors thank ICI Surfactants for financial support. This work was supported by the Hungarian National Research Fund (OTKA) (project no. T 026579).

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, University of Szeged, Eötvös utca 6., 6720, Szeged, Hungary

    Melinda Makai, Erzsébet Csányi & István Erős

  2. Department of Colloid Chemistry, University of Szeged, Aradi Vértanuk tere 1., 6720, Szeged, Hungary

    Imre Dékány

  3. Department of Physical Chemistry, Technical University of Budapest, 8 Budafoki út 8., 1111 , Budapest, Hungary

    Zsolt Németh

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  1. Melinda Makai
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  2. Erzsébet Csányi
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  3. Imre Dékány
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  4. Zsolt Németh
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  5. István Erős
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Correspondence to Imre Dékány.

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Makai, M., Csányi, E., Dékány, I. et al. Structural properties of nonionic surfactant/glycerol/paraffin lyotropic liquid crystals. Colloid Polym Sci 281, 839–844 (2003). https://doi.org/10.1007/s00396-002-0851-4

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  • DOI: https://doi.org/10.1007/s00396-002-0851-4

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