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Porphyrin-cyclodextrin supramolecular complexes as myoglobin model in water

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Abstract

This mini-review reports supramolecular system composed of O-methylated β-cyclodextrins and metalloporphyrins that mimic the functions of myoglobin (Mb) in aqueous solution. Although many Mb functional models have been demonstrated so far, most models can bind dioxygen only in organic solvents such as toluene. Recently, we prepared the model systems composed of O-methylated β-cyclodextrin dimers having pyridine and imidazole linkers and tetrakis(4-sulfonatophenyl)porphinato iron(II) (hemoCD and Fe(II)PImCD). HemoCD binds dioxygen reversibly in aqueous solution, and the dioxygen adduct of hemoCD is very stable (a half-lifetime is 30 h at pH 7). Although the dioxygen affinity of Fe(II)PImCD is much higher than hemoCD, the stability and the reversibility of this system is lower. This review compares the functions of these model systems with those in biological systems.

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Authors and Affiliations

  1. Department of Molecular Science and Technology, Doshisha University, Kyotanabe, Kyoto, 610-0321, Japan

    Koji Kano

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  1. Koji Kano
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Correspondence to Koji Kano.

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This review was written to dedicate to Professor Janos H. Fendler on the occasion of his 70th birthday. He gave me a chance to study biomimetic chemistry when he was a professor of Texas A&M University.

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Kano, K. Porphyrin-cyclodextrin supramolecular complexes as myoglobin model in water. Colloid Polym Sci 286, 79–84 (2008). https://doi.org/10.1007/s00396-007-1724-7

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  • DOI: https://doi.org/10.1007/s00396-007-1724-7

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