Abstract
The critical concentrations of amitriptyline, desipramine and nortriptyline hydrochlorides in aqueous solution were determined over the temperature range 288–313 K by a method based on deconvolution into Gaussians of the second derivate of the measured specific conductivity data. The mass-action model was used to calculate the thermodynamic quantities: standard free Gibbs energy, standard enthalpy and standard entropy of aggregate formation. The results are discussed in terms of the structure of the drug aggregates.
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Received: 12 June 2000 / in revised form: 10 October 2000 Accepted: 16 October 2000
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Taboada, P., Ruso, J., García, M. et al. Comparison of the thermodynamic properties of structurally related amphiphilic antidepressants in aqueous solution. Colloid Polym Sci 279, 716–720 (2001). https://doi.org/10.1007/s003960100495
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DOI: https://doi.org/10.1007/s003960100495