Skip to main content

Advertisement

SpringerLink
Log in

Cognitive complaints in Parkinson’s disease: its relationship with objective cognitive decline

  • Original Communication
  • Published:
Journal of Neurology Aims and scope Submit manuscript

Abstract

Cognitive complaint interviews (CCI) have been shown to be useful in the early detection of dementia in elderly people. Surprisingly, CCIs are rarely used in Parkinson’s disease (PD), despite a six-fold higher risk of dementia than in healthy subjects. The present study sought to determine whether a structured CCI could detect cognitive decline in PD. A validated CCI was added to the usual clinical interview for 180 PD patients. Objective cognitive status was assessed by the Mattis dementia rating scale score. The CCIs ability to detect cognitive decline in PD patients was determined using a receiver operating characteristic (ROC) curve. 58 (32.22%) patients had a significant, subjective cognitive complaint (CCI score >3). Of these, 48.27% had objective cognitive decline. Objective cognitive decline was significantly more frequent in the patients with subjective cognitive complaint. However, the ROC curve for discriminating between patients with and without objective cognitive deficits as a function of their subjective cognitive complaint had low sensitivity (0.50, 95% CI: 0.36–0.64) and moderate specificity (0.74, 95% CI: 0.69–0.84). Logistic regression incorporating the main demographical and clinical variables showed that the CCI score’s discriminant power was improved by adding age and the number of years in education to the predictive model. Objective cognitive decline and dementia are more frequent among PD patients reporting a cognitive complaint than among patients not reporting a complaint. However, the CCI does not enable more accurate screening for PD-associated dementia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Dujardin K et al (1999) Neuropsychological abnormalities in first degree relatives of patients with familial Parkinson’s disease. J Neurol Neurosurg Psychiatry 67(3):323–328

    Article  CAS  PubMed  Google Scholar 

  2. Muslimovic D et al (2005) Cognitive profile of patients with newly diagnosed Parkinson disease. Neurology 65(8):1239–1245

    Article  PubMed  Google Scholar 

  3. Emre M (2003) Dementia associated with Parkinson’s disease. Lancet Neurol 2(4):229–237

    Article  CAS  PubMed  Google Scholar 

  4. Emre M (2004) Dementia in Parkinson’s disease: cause and treatment. Curr Opin Neurol 17(4):399–404

    Article  PubMed  Google Scholar 

  5. Bosboom JL, Stoffers D, Wolters E (2004) Cognitive dysfunction and dementia in Parkinson’s disease. J Neural Transm 111(10–11):1303–1315

    Article  CAS  PubMed  Google Scholar 

  6. Martinez-Martin P et al (2005) Quality of life of caregivers in Parkinson’s disease. Qual Life Res 14(2):463–472

    Article  PubMed  Google Scholar 

  7. Buter TC et al (2008) Dementia and survival in Parkinson disease: a 12-year population study. Neurology 70(13):1017–1022

    Article  CAS  PubMed  Google Scholar 

  8. Parashos SA et al (2002) Medical services utilization and prognosis in Parkinson disease: a population-based study. Mayo Clin Proc 77(9):918–925

    Article  PubMed  Google Scholar 

  9. Emre M et al (2004) Rivastigmine for dementia associated with Parkinson’s disease. N Engl J Med 351(24):2509–2518

    Article  CAS  PubMed  Google Scholar 

  10. Bak TH et al (2005) Cognitive bedside assessment in atypical Parkinsonian syndromes. J Neurol Neurosurg Psychiatry 76(3):420–422

    Article  CAS  PubMed  Google Scholar 

  11. Athey RJ, Walker RW (2006) Demonstration of cognitive decline in Parkinson’s disease using the Cambridge cognitive assessment (Revised CAMCOG-R). Int J Geriatr Psychiatry 21(10):977–982

    Article  PubMed  Google Scholar 

  12. Zadikoff C et al (2008) A comparison of the mini mental state exam to the montreal cognitive assessment in identifying cognitive deficits in Parkinson’s disease. Mov Disord 23(2):297–299

    Article  PubMed  Google Scholar 

  13. Marinus J et al (2003) Assessment of cognition in Parkinson’s disease. Neurology 61(9):1222–1228

    CAS  PubMed  Google Scholar 

  14. Schmand B et al (1996) Subjective memory complaints may announce dementia. Neurology 46(1):121–125

    CAS  PubMed  Google Scholar 

  15. Schofield PW et al (1997) The validity of new memory complaints in the elderly. Arch Neurol 54(6):756–759

    CAS  PubMed  Google Scholar 

  16. Gagnon M et al (1994) Self-reported memory complaints and memory performance in elderly French community residents: results of the PAQUID Research Program. Neuroepidemiology 13(4):145–154

    Article  CAS  PubMed  Google Scholar 

  17. Thomas-Anterion C. et al. (2003) Le questionnaire de plainte cognitive: un outil de recherche de plainte suspecte d’évoquer une maladie d’Alzheimer? L’année gérontologique 56–65

  18. Miranda B et al (2008) Self-perceived memory impairment and cognitive performance in an elderly independent population with age-related white matter changes. J Neurol Neurosurg Psychiatry 79(8):869–873

    Article  CAS  PubMed  Google Scholar 

  19. Gelb DJ, Oliver E, Gilman S (1999) Diagnostic criteria for Parkinson disease. Arch Neurol 56(1):33–39

    Article  CAS  PubMed  Google Scholar 

  20. Marsh L et al (2006) Provisional diagnostic criteria for depression in Parkinson’s disease: report of an NINDS/NIMH work group. Mov Disord 21(2):148–158

    Article  PubMed  Google Scholar 

  21. Thomas-Anterion C, Honore-Masson S, Laurent B (2006) The cognitive complaint interview. Psychogeriatrics 6(1):18–22

    Article  Google Scholar 

  22. Montgomery SA, Asberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382–389

    Article  CAS  PubMed  Google Scholar 

  23. Monsch AU et al (1995) Clinical validity of the Mattis dementia rating scale in detecting dementia of the Alzheimer type. A double cross-validation and application to a community-dwelling sample. Arch Neurol 52(9):899–904

    CAS  PubMed  Google Scholar 

  24. Brown GG et al (1999) Validity of the dementia rating scale in assessing cognitive function in Parkinson’s disease. J Geriatr Psychiatry Neurol 12(4):180–188

    Article  CAS  PubMed  Google Scholar 

  25. Green RC, Woodard JL, Green J (1995) Validity of the Mattis dementia rating scale for detection of cognitive impairment in the elderly. J Neuropsychiatry Clin Neurosci 7(3):357–360

    CAS  PubMed  Google Scholar 

  26. Emre M et al (2007) Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Mov Disord 22(12):1689–1707 quiz 1837

    Article  PubMed  Google Scholar 

  27. Van der Linden M (2004) L’épreuve de rappel libre/rappel indicé à 16 items (RL/RI-16). In: Van der Linden M, Gremem et al (eds) L’évaluation des troubles de la mémoire. Solal, Marseille, pp 25–47

    Google Scholar 

  28. Pillon B et al (1993) Explicit memory in Alzheimer’s, Huntington’s, and Parkinson’s diseases. Arch Neurol 50(4):374–379

    CAS  PubMed  Google Scholar 

  29. Dujardin K et al (2001) Memory and executive function in sporadic and familial Parkinson’s disease. Brain 124(Pt 2):389–398

    Article  CAS  PubMed  Google Scholar 

  30. Rouch I et al (2008) Cognitive complaints, neuropsychological performance and affective disorders in elderly community residents. Disabil Rehabil 30(23):1794–1802

    Article  CAS  PubMed  Google Scholar 

Download references

Conflicts of interest statement

The authors report no conflicts of interest.

Author information

Authors and Affiliations

  1. Neurology and Movement Disorders Unit, EA2683, Faculty of Medicine and University Medical Center, Lille, France

    Kathy Dujardin, Marie Delliaux, Alain Destée & Luc Defebvre

  2. Biostatistics Department, Faculty of Medicine, Lille, France

    Alain Duhamel

  3. Neurology Unit, University Medical Center, Saint-Etienne, France

    Catherine Thomas-Antérion

  4. Neurologie et Pathologie du Mouvement, Neurologie A, Hôpital Salengro, Centre Hospitalier Universitaire, 59037, Lille Cedex, France

    Kathy Dujardin

Authors
  1. Kathy Dujardin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alain Duhamel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marie Delliaux
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Catherine Thomas-Antérion
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alain Destée
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Luc Defebvre
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kathy Dujardin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dujardin, K., Duhamel, A., Delliaux, M. et al. Cognitive complaints in Parkinson’s disease: its relationship with objective cognitive decline. J Neurol 257, 79–84 (2010). https://doi.org/10.1007/s00415-009-5268-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-009-5268-2

Keywords

Search

Navigation