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Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients

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Abstract

Little is known about the relationship between cognitive dysfunctions and the non-motor complex in subjects with newly diagnosed untreated Parkinson’s disease (PD). The aim of this study was to explore the association between non-motor symptoms (NMS) and cognitive dysfunctions in an incident cohort of de novo, drug-naive, PD patients. Sixty-six non-demented, early, untreated PD patients completed a semi-structured interview on NMS and a battery of neuropsychological tests that assess verbal memory, visuospatial abilities, and attention/executive functions. Scores were age- and education-corrected. Patients who failed at least two tests for each cognitive domain were diagnosed as having mild cognitive impairment (MCI). All but three (95.4%) PD patients complained of at least one NMS. A total of 37.8% was diagnosed with MCI. There was a relationship between sleep-NMS and cognitive dysfunctions. Specifically, both REM behavioral sleep disorders (RBD) and insomnia were associated with lower scores on several cognitive tests. Moreover, RBD was closely related to MCI. NMS and MCI are very common even in the early phase of PD, before patients are treated. Given the correlation between sleep disturbances and cognitive impairment, it is possible that sleep symptoms in PD patients might be considered as an early marker of dementia.

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Acknowledgments

We are grateful to Jean Ann Gilder (Scientific Communications srl) for editing the text.

Conflicts of interest

Roberto Erro, Marina Picillo, Anna De Rosa, Maria Teresa Pellecchia, Giuseppe De Michele, Lucio Santoro have received honoraria from Department of Neurological Sciences-University of Naples “Federico II”. Gabriella Santangelo has received honoraria from Department of Psychology of Second University of Naples, Caserta, Italy. Carmine Vitale has received honoraria for symposia from Boehringer Ingelheim, Lundbeck, Novartis and Schwarz Pharma/UCB. He has received salary from IDC Hermitage-Capodimonte and the University of Naples “Parthenope”, Italy. Katia Longo has received salary from IDC Hermitage-Capodimonte. Marianna Amboni has received honoraria for symposia from Boehringer Ingelheim, Lundbeck, Novartis. She has received salary from IDC Hermitage-Capodimonte. Prof. P. Barone has received honoraria as a Consultant & Advisory Board Memberships for Novartis, Schwarz Pharma/UCB, Merck-Serono, Eisai, Solvay, General Electric and Lundbeck. Has received research support from Boehringer Ingelheim, Novartis, Schwarz Pharma/UCB, Merck-Serono, Solvay, and Lundbeck. He has received salary from the University of Salerno. All other authors have no financial disclosures.

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Authors and Affiliations

  1. Department of Neurological Science, University of Naples Federico II, Naples, Italy

    Roberto Erro, Marina Picillo, Carmine Vitale, Marianna Amboni, Katia Longo, Angela Costagliola, Roberto Allocca, Anna De Rosa, Giuseppe De Michele & Lucio Santoro

  2. Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy

    Gabriella Santangelo

  3. IDC Hermitage, Capodimonte, Naples, Italy

    Gabriella Santangelo, Carmine Vitale, Marianna Amboni & Katia Longo

  4. University of Naples Parthenope, Naples, Italy

    Carmine Vitale

  5. School of Medicine, Center for Neurodegenerative diseases, University of Salerno, Salerno, Italy

    Maria Teresa Pellecchia & Paolo Barone

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  1. Roberto Erro
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  2. Gabriella Santangelo
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  3. Marina Picillo
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  4. Carmine Vitale
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  8. Maria Teresa Pellecchia
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  11. Giuseppe De Michele
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Corresponding author

Correspondence to Paolo Barone.

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Erro, R., Santangelo, G., Picillo, M. et al. Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients. J Neurol 259, 1808–1813 (2012). https://doi.org/10.1007/s00415-011-6407-0

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  • DOI: https://doi.org/10.1007/s00415-011-6407-0

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