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Bifurcation analysis of a Morris–Lecar neuron model

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Abstract

In this paper, we investigate the dynamical behaviors of a Morris–Lecar neuron model. By using bifurcation methods and numerical simulations, we examine the global structure of bifurcations of the model. Results are summarized in various two-parameter bifurcation diagrams with the stimulating current as the abscissa and the other parameter as the ordinate. We also give the one-parameter bifurcation diagrams and pay much attention to the emergence of periodic solutions and bistability. Different membrane excitability is obtained by bifurcation analysis and frequency-current curves. The alteration of the membrane properties of the Morris–Lecar neurons is discussed.

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References

  • FitzHugh R (1955) Mathematical models of threshold phenomena in the nerve membrane. Bull Math Biophys 7:252–278

    Google Scholar 

  • Guckenheimer J, Holmes P (1983) Dynamical systems and bifurcations of vector Fields. Nonlinear oscillations. Springer, New York

    Google Scholar 

  • Gutkin BS, Ermentrout GB (1998) Dynamics of membrane excitability determine interspike interval variability: a link between spike generation mechanisms and cortical spike train statistics. Neural Comput 10:1047–1065

    Article  CAS  PubMed  Google Scholar 

  • Hodgkin AL (1948) The local electric changes associated with repetitive action in a non-medullated axon. J Physiol 107:165–181

    CAS  PubMed  Google Scholar 

  • Izhikevich EM (2000) Neural excitability, spiking and bursting. Int J Bifurcation Chaos 10:1171–1266

    Article  Google Scholar 

  • Izhikevich EM (2007) Dynamical systems in neuroscience. MIT Press, Cambridge, MA

    Google Scholar 

  • Kepler TB, Abbott LF, Marder E (1992) Reduction of conductance-based neuron models. Biol Cybern 66:381–387

    Article  CAS  PubMed  Google Scholar 

  • Koch C (1999) Biophysics of computation. Oxford University Press, New York

    Google Scholar 

  • Kuznetsov YA (1998) Elements of applied bifurcation theory, 2nd edn. Springer, New York

    Google Scholar 

  • Kuznetsov et al (2010) MATCONT is available at http://www.matcont.ugent.be

  • Morris C, Lecar H (1981) Voltage oscillations in the barnacle giant muscle fiber. Biophys J 35:193–213

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Prescott SA, De Koninck Y (2002) Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat. J Physiol 539:817–836

    Article  CAS  PubMed  Google Scholar 

  • Prescott SA, De Koninck Y, Sejnowski TJ (2008) Biophysical basis for three distinct dynamical mechanisms of action potential initiation. PLOS Comput Biol 4:1–18

    Article  Google Scholar 

  • Rinzel J, Ermentrout GB (1989) Analysis of neural excitability and oscillations. In: Koch C, Segev I (eds) Methods in neuronal modeling: from Ions to networks. MIT Press, Cambridge, MA, pp 251–291

  • Sculptoreanu A, De Groat WC (2007) Neurokinins enhance excitability in capsaicin-responsive DRG neurons. Exp Neurol 205: 92–100

    Google Scholar 

  • Smith PH (1995) Structural and functional differences distinguish principal from nonprincipal cells in the guinea pig MSO slice. J Neurophysiol 73:1653–1667

    CAS  PubMed  Google Scholar 

  • Tsuji S, Ueta T et al (2007) Bifurcations in two-dimensional Hindmarsh–Rose type model. Int J Bifurcation Chaos 17:985–998

    Google Scholar 

  • Tsumoto K, Kitajima H et al (2006) Bifurcations in Morris–Lecar neuron model. Neurocomputing 69:293–316

    Article  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No. 11172103). The authors are grateful to the referees for their valuable suggestions, which helped us to improve the manuscript.

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Correspondence to Xuanliang Liu.

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Liu, C., Liu, X. & Liu, S. Bifurcation analysis of a Morris–Lecar neuron model. Biol Cybern 108, 75–84 (2014). https://doi.org/10.1007/s00422-013-0580-4

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  • DOI: https://doi.org/10.1007/s00422-013-0580-4

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