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The role of the mitochondrial calcium uniporter (MCU) complex in cancer

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Abstract

The important role of mitochondria in cancer biology is gaining momentum. With their regulation of cell survival, metabolism, basic cell building blocks, and immunity, among other functions, mitochondria affect not only cancer progression but also the response and resistance to current treatments. Calcium ions are constantly shuttled in and out of mitochondria; thus, playing an important role in the regulation of various cellular processes. The mitochondrial calcium uniporter (MCU) channel and its associated regulators transport calcium across the inner mitochondrial membrane to the mitochondrial matrix. Due to this central role and the capacity to affect cell behavior and fate, the MCU complex is being investigated in different cancers and cancer-related conditions. Here, we review current knowledge on the role of the MCU complex in multiple cancer types and models; we also provide a perspective for future research and clinical considerations.

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Funding

This work was supported by the German Research Foundation (DFG) projects: SFB1190 project 17, SFB1027 Project C4, IRTG1816, and BO3643/3-2.

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Authors and Affiliations

  1. Molecular Physiology, Institute of Cardiovascular Physiology, University Medical Center, Georg-August-University, Humboldtallee 23, 37073, Göttingen, Germany

    Adina Vultur, Christine S. Gibhardt & Ivan Bogeski

  2. Department of Dermatology, Venereology and Allergology, University Medical Center, Georg-August-University, Göttingen, Germany

    Hedwig Stanisz

Authors
  1. Adina Vultur
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  2. Christine S. Gibhardt
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  3. Hedwig Stanisz
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  4. Ivan Bogeski
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Corresponding author

Correspondence to Ivan Bogeski.

Additional information

This article is part of the special issue on Mitochondrial Signalling in Pflügers Archiv—European Journal of Physiology

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Vultur, A., Gibhardt, C.S., Stanisz, H. et al. The role of the mitochondrial calcium uniporter (MCU) complex in cancer. Pflugers Arch - Eur J Physiol 470, 1149–1163 (2018). https://doi.org/10.1007/s00424-018-2162-8

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  • DOI: https://doi.org/10.1007/s00424-018-2162-8

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