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Heat shock protein 100 and the amastigote stage-specific A2 proteins of Leishmania donovani

  • Leishmania and the Leishmaniases
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Abstract.

HSP100 protein in Leishmania spp. plays an important role for the survival and integrity of intracellular amastigotes. The A2 proteins of L. donovani are functionally linked to HSP100. There is evidence for an interdependence between these two proteins, which are both expressed predominantly in the amastigote stage of Leishmania donovani. Mutant strains lacking either of these proteins display very similar phenotypes, i.e. loss of virulence both in vivo and in vitro. Also, both proteins colocalise specifically to small foci within the cytoplasm of amastigotes.

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Authors and Affiliations

  1. Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, Germany

    Joachim Clos, Linda Klaholz, Manfred Kroemer & Sylvia Krobitsch

  2. Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USA, USA

    Susan Lindquist

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  1. Joachim Clos
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  2. Linda Klaholz
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  3. Manfred Kroemer
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  4. Sylvia Krobitsch
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  5. Susan Lindquist
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Clos, J., Klaholz, L., Kroemer, M. et al. Heat shock protein 100 and the amastigote stage-specific A2 proteins of Leishmania donovani . Med Microbiol Immunol 190, 47–50 (2001). https://doi.org/10.1007/s004300100078

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  • DOI: https://doi.org/10.1007/s004300100078

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