Abstract
In this study, potassium-doped zinc oxide nanoparticles (K-doped ZnO NPs) were green-synthesized using pine pollen extracts based on bioethics principles. The synthesized NPs were analyzed using X-ray diffraction (XRD), inductively coupled plasma atomic emission spectroscopy (ICP-AES), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDXA), and transmission electron microscopy (TEM). The cytotoxicity of these nanoparticles (NPs) on normal macrophage cells and cancer cell lines was evaluated. In the same concentrations of K-doped ZnO and pure ZnO NPs, K-doped ZnO NPs demonstrated higher toxicity. The results confirmed that the doped potassium could increase cytotoxicity. The IC50 of K-doped ZnO NPs, pure ZnO NPs, and the examined control drug were 497 ± 15, 769 ± 12, and 606 ± 19 µg/mL, respectively. Considering the obtained IC50 of K-doped ZnO NPs, they were more toxic to the cancer cell lines and had less cytotoxicity on normal macrophage cells.
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This study was funded by Behbahan Faculty of Medical Sciences under research project (grant number 400016).
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Haghighat, M., Alijani, H.Q., Ghasemi, M. et al. Cytotoxicity properties of plant-mediated synthesized K-doped ZnO nanostructures. Bioprocess Biosyst Eng 45, 97–105 (2022). https://doi.org/10.1007/s00449-021-02643-2
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DOI: https://doi.org/10.1007/s00449-021-02643-2