Skip to main content
SpringerLink
Log in

Captopril scintigraphy in the study of arterial hypertension in pediatrics

  • Original Article
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

Renovascular hypertension (RVH) is responsible for 10% of arterial hypertension in children. The early diagnosis of RVH permits specific treatment leading to the cure of hypertension and avoidance of parenchymal damage. Captopril renal scintigraphy (CRS) provides information on the renovascular cause of the arterial hypertension. To validate the usefulness of CRS in hypertensive children, clinical, scintigraphic, and radiological data from 20 patients (mean age 6.1±5.5 years) were reviewed. Two patients were newborns. All had renal ultrasound scans and 9 had aortograms. In 7 children, RVH was confirmed by angiography, and CRS was positive for RVH in 6 of these. CRS was negative for RVH in 12 of 13 children without RVH. CRS was non-diagnostic in 3 children with abnormal baseline renal scintigraphy and severely decreased relative renal function (<35%), 1 of whom had RVH. No side effects of captopril renography were observed. Captopril renography provides a logical, non-invasive, safe, and cost-effective approach in the evaluation of children suspected of having RVH.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hiner LB, Falkner B (1993) Renovascular hypertension in children. Pediatr Clin North Am 40:122–140

    Google Scholar 

  2. Deal JE, Snell MF, Barratt TM, Dillon NJ (1992) Renovascular disease in childhood. J Pediatr 121:378–384

    CAS  PubMed  Google Scholar 

  3. Dillon MJ (1997) The diagnosis of renovascular disease. Pediatr Nephrol 11:366–372

    CAS  PubMed  Google Scholar 

  4. Wells TG, Belsha CW (1996) Pediatric renovascular hypertension. Curr Opin Pediatr 8:128–134

    PubMed  Google Scholar 

  5. Flynn JT (2000) Neonatal hypertension: diagnosis and management. Pediatr Nephrol 14:332–341

    Article  CAS  PubMed  Google Scholar 

  6. Shahdadpuri J, Frank R, Gauthier BG, Siegel DN, Trachtman H (2000) Yield of renal arteriography in the evaluation of pediatric hypertension. Pediatr Nephrol 14:816–819

    PubMed  Google Scholar 

  7. Rankin SC, Saunders AJ, Cook GJ, Scoble JE (2000) Renovascular disease. Clin Radiol 55:1–12

    Article  CAS  Google Scholar 

  8. Soulez G, Oliva VL, Turpin S, Lambert R, Nicolet V, Therasse E (2000) Imaging of renovascular hypertension: respective values of renal scintigraphy, renal Doppler US and MR angiography. Radiographics 20:1355–1368

    CAS  PubMed  Google Scholar 

  9. Johansson M, Jensen G, Aurell M, Friberg P, Herlitz H, Klingenstierna H, Volkmann R (2000) Evaluation of duplex ultrasound and captopril renography for detection of renovascular hypertension. Kidney Int 58:774–782

    Article  PubMed  Google Scholar 

  10. Mitty HA, Shapiro RS, Parsons RB, Silberzweig JE (1996) Renovascular hypertension. Radiol Clin North Am 34:1017–1036

    PubMed  Google Scholar 

  11. Orellana P, Jalil R, Valdes F, Fava M, Olea E, Fernández M, Valdés G, Contreras O, Fontbote C (1993) Renal scintigraphy with captopril in the evaluation of renovascular hypertension. Rev Med Chil 121:762–767

    PubMed  Google Scholar 

  12. Minty I, Lythgoe MF, Gordon I (1993) Hypertension in paediatrics: can pre- and post-captopril technetium-99m dimercaptosuccinic acid renal scans exclude renovascular disease? Eur J Nucl Med 20:699–702

    PubMed  Google Scholar 

  13. Estepa R, Gallego N, Orte L, Puras E, Aracil E, Ortuño J (2001) Renovascular hypertension in children. Scand J Urol Nephrol 35:388–392

    Article  PubMed  Google Scholar 

  14. Chandar JJ, Sfakianakis GN, Zilleruelo GE, Guerra JJ, Georgiou MF, Abitbol CL, Montane BS, Strauss J (1999) ACE inhibition scintigraphy in the management of hypertension in children. Pediatr Nephrol 13:493–500

    CAS  PubMed  Google Scholar 

  15. Ng CS, Bruyn R de, Gordon I (1997) The investigation of renovascular hypertension in children: the accuracy of radio-isotopes in detecting renovascular disease. Nucl Med Commun 18:1017–1028

    PubMed  Google Scholar 

  16. National High Blood Pressure Education Program of Hypertension Control in Children and Adolescents (1996) Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents: a working group report from the National High Blood Pressure Education Program. Pediatrics 98:649–658

    PubMed  Google Scholar 

  17. Piepz A, Hahn K, Roca I, Ciofetta G, Toth G, Gordon I, Kolinska J, Gwidlet J Paediatric Task Group European Association Nuclear Medicine Members (1990) A radiopharmaceuticals schedule for imaging in paediatrics. Eur J Nucl Med 17:127–129

    CAS  PubMed  Google Scholar 

  18. Taylor A, Nally J, Aurell M, Blaufox D, Dondi M, Dubovsky E, Fine E, Fommei E, Geyskes G, Granerus G, Kahn D, Morton K, Oey HY, Russell C, Sfakianakis G, Fletcher J (1996) Consensus report on ACE inhibitor renography for detecting renovascular hypertension. J Nucl Med 37:1876–1882

    PubMed  Google Scholar 

  19. Daniels SR, Loggie JM, McEnery PT, Towbin RB (1987) Clinical spectrum of intrinsic renovasuclar hypertension in children. Pediatrics 80:698–704

    PubMed  Google Scholar 

  20. Adelman RD (1988) The hypertensive neonate. Clin Perinatol 15:567–585

    CAS  PubMed  Google Scholar 

  21. Lagomarsino E, Tapia JR, Ventura-Junca P (eds) (2000) Arterial hypertension: manual de neonatología, 2nd edn. Publicaciones Técnicas Mediterráneas, Santiago, Chile, pp 505–510

    Google Scholar 

  22. Prigent A (1993) The diagnosis of renovascular hypertension: the role of captopril renal scintigraphy and related issues. Eur J Nucl Med 20:625–644

    PubMed  Google Scholar 

  23. Lenz T, Kia T, Rupprecht G, Schulte KL, Geiger H (1999) Captopril test: time over? J Hum Hypertens 13:431–435

    Article  PubMed  Google Scholar 

  24. Shamlou KK, Drane WE, Hawkins IF, Fennell RS (1994) Captopril renography and the hypertensive renal transplant patient: a predictive test of therapeutic outcome. Radiology 190:153–159

    CAS  PubMed  Google Scholar 

  25. Taylor A (1999) Radionuclide renography: a personal approach. Semin Nucl Med 29:102–127

    CAS  Google Scholar 

  26. Van de Wiele C, Brans B, Vanholder R, Hoeben H, Van Laere K, Dierckx RA (1999) Predictive value of 99 Tcm-DTPA captopril scintigraphy in patients with a solitary kidney and reduced kidney function. Nucl Med Commun 20:263–266

    PubMed  Google Scholar 

  27. Levey CS, Schraml FV, Abreu SH, Silverman ED (1999) False positive result of captopril-enhanced radionuclide renogram in a child secondary to dehydration. Clin Nucl Med 24:6–8

    Article  CAS  Google Scholar 

  28. Claveau-Tremblay R, Turpin S, De Braekeleer M, Brassard A, Leblond R (1998) False-positive captopril renography in patients taking calcium antagonists. J Nucl Med 39:1621–1626

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, School of Medicine, Catholic University of Chile, Santiago, Chile

    Edda Lagomarsino, Pilar Orellana, Jaime Muñoz & Felipe Cavagnaro

  2. Department of Radiology, Nuclear Medicine Section, School of Medicine, Catholic University of Chile, Santiago, Chile

    Pilar Orellana & Claudia Velásquez

  3. Cardiovascular Section, Surgery Division, School of Medicine, Catholic University of Chile, Santiago, Chile

    Francisco Valdés

  4. Nuclear Medicine Section, Catholic University Hospital, Marcoleta 347, Santiago, Chile

    Pilar Orellana

Authors
  1. Edda Lagomarsino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pilar Orellana
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jaime Muñoz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Claudia Velásquez
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Felipe Cavagnaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Francisco Valdés
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pilar Orellana.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lagomarsino, E., Orellana, P., Muñoz, J. et al. Captopril scintigraphy in the study of arterial hypertension in pediatrics. Pediatr Nephrol 19, 66–70 (2004). https://doi.org/10.1007/s00467-003-1285-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00467-003-1285-z

Keywords

Search

Navigation