Zusammenfassung
Hintergrund
Im Brustkorb lokalisierte Beschwerden werden von Personen der allgemeinen Bevölkerung häufig angegeben und stellen eine differenzialdiagnostische Herausforderung dar.
Material und Methoden
Narrative Übersicht mit selektiver Literatursuche in der Datenbank Medline nach Übersichtsarbeiten und Leitlinien zur Häufigkeit und Therapie von nichtmalignen Erkrankungen aus der Gastroenterologie, Gynäkologie und Kardiologie mit Leitsymptom eines im Brustkorb lokalisierten chronischen Schmerzes.
Ergebnisse
Häufigkeit, Beschwerdebild und aktuelle Behandlungskonzepte der verschiedenen Formen der Refluxösophagitis (erosive und nichterosive Form, irritabler Ösophagus), des nichtkardialen Brustschmerzes, der refraktären Angina pectoris bei koronarer Herzerkrankung sowie des Postmastektomie- und Poststernotomiesyndroms werden dargestellt. Im Falle des Versagens der etablierten gebietsbezogenen Therapie ist eine interdisziplinäre einschließlich psychosoziale Diagnostik empfehlenswert. Zur Behandlung der Refluxösophagitis und der refraktären Angina pectoris bei koronarer Herzerkrankung liegen evidenzbasierte Leitlinien vor. Die Behandlung des Postmastektomie- und Poststernotomiesyndroms stützt sich auf Fallberichte und Expertenmeinungen.
Schlussfolgerungen
Es besteht Forschungsbedarf zur symptomatischen Schmerztherapie des irritablen Ösophagus, des nichtkardialen Brustschmerzes sowie des Postmastektomie- und Poststernotomiesyndroms.
Abstract
Background
Chest pain is a symptom commonly reported by persons in the general population and represents a differential diagnostic challenge.
Material and methods
The paper is based on a narrative review with a selective search of the literature in Medline for reviews and guidelines on the prevalence and treatment of non-malignant diseases with chronic chest pain in gastroenterology, gynecology and cardiology.
Results
The prevalence and current treatment recommendations for the different forms of gastroesophageal reflux disease (GERD), erosive and non-erosive types and irritable esophagus, non-cardiac chest pain, refractory angina in coronary heart disease and postmastectomy nand poststernotomy syndromes are presented. In cases of failure of the established therapy of a single medical discipline, an interdisciplinary assessment including psychosocial issues is recommended. Evidence-based guidelines are available for the management of GERD and of refractory angina. Treatment of postmastectomy and poststernotomy syndromes is based on case reports and expert opinion.
Conclusion
There is a need for controlled studies on the symptomatic treatment of pain in irritable esophagus, non-cardiac chest pain, postmastectomy and poststernotomy syndromes.
Literatur
Amin F, Al Hajeri A, Civelek B et al (2010) Enhanced external counterpulsation for chronic angina pectoris. Cochrane Database Syst Rev 2:CD007219
Amr YM, Yousef AA (2010) Evaluation of efficacy of the perioperative administration of venlafaxine or gabapentin on acute and chronic postmastectomy pain. Clin J Pain 26:381–385
Bellach BM, Ellert U, Radoschewski M (2000) Epidemiologie des Schmerzes – Ergebnisse des Bundesgesundheitssurvey 1998. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 42:421–432
Bösner S, Becker A, Haasenritter J et al (2009) Chest pain in primary care: epidemiology and pre-work-up probabilities. Eur J Gen Pract 15:141–146
Braverman DL (2012) Enhanced external counterpulsation: a novel therapy for angina. Complement Ther Clin Pract 18:197–203
Bradley LA, Richter JE, Pulliam TJ et al (1993) The relationship between stress and symptoms of gastroesophageal reflux: the influence of psychological factors. Am J Gastroenterol 88:11–19
Briones E, Lacalle JR, Marin I (2009) Transmyocardial laser revascularization versus medical therapy for refractory angina. Cochrane Database Syst Rev 1:CD003712
Coss-Adame E, Erdogan A, Rao SS (2013) Treatment of esophageal (noncardiac) chest pain: a review. Clin Gastroenterol Hepatol (im Druck)
Eisenberg E, Pultorak Y, Pud D, Bar-El Y (2001) Prevalence and characteristics of post coronary artery bypass graft surgery pain (PCP). Pain 92:11–17
El-Serag HB, Sweet S, Winchester CC, Dent J (2013) Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut (im Druck)
The Gallup Organization (1998) Gallup survey on heartburn across America. Princeton
Fass R, Achem SR (2011) Noncardiac chest pain: epidemiology, natural course and pathogenesis. J Neurogastroenterol Motil 110–123
Fernández-Lao C, Cantarero-Villanueva I, Fernández-de-Las-Peñas C et al (2010) Myofascial trigger points in neck and shoulder muscles and widespread pressure pain hypersensitivity in patients with postmastectomy pain: evidence of peripheral and central sensitization. Clin J Pain 26:798–806
Frettlöh J, Maier C, Gockel H et al (2009) Characterization of chronic pain patients in German pain centers: core data from more than 10,000 patients. Schmerz 23:576–591
Gärtner R, Jensen MB, Nielsen J et al (2009) Prevalence of and factors associated with persistent pain following breast cancer surgery. JAMA 302:1985–1992
Häuser W, Schmutzer G, Hinz A et al (2013) Prevalence of chronic pain in Germany. A representative survey of the general population. Schmerz 27:46–55
Jespersen L, Abildstrøm SZ, Hvelplund A, Prescott E (2013) Persistent angina: highly prevalent and associated with long-term anxiety, depression, low physical functioning, and quality of life in stable angina pectoris. Clin Res Cardiol 102:571–581
Katz PO, Gerson LB, Vela MF (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 108:308–328
Koop H, Schepp W, Müller-Lissner S et al (2005) Consensus conference of the DGVS on gastroesophageal reflux. Z Gastroenterol 43:163–164
Labrèze L, Dixmérias-Iskandar F, Monnin D et al (2007) Postmastectomy pain syndrome evidence based guidelines and decision trees. Bull Cancer 94:275–285
Lahtinen P, Kokki H, Hynynen M (2006) Pain after cardiac surgery: a prospective cohort study of 1-year incidence and intensity. Anesthesiology 105:794–800
Lanza GA, Barone L, Di Monaco A (2012) Effect of spinal cord stimulation in patients with refractory angina: evidence from observational studies. Neuromodulation 15:542–549
Locke GR III, Horwhat J, Mashimo H et al (2013) Endotherapy for and tailored approaches to treating GERD, and refractory GERD. Ann N Y Acad Sci 1300:166–186
Mannheimer C, Camici P, Chester MR et al (2002) The problem of chronic refractory angina; report from the ESC Joint Study Group on the Treatment of Refractory Angina. Eur Heart J 23:355–370
McGillion M, Arthur H, Victor JC et al (2008) Effectiveness of psychoeducational interventions for improving symptoms, health-related quality of life, and psychological well being in patients with stable angina. Curr Cardiol Rev 4:1–11
McGillion M, Arthur HM, Cook A et al (2012) Management of patients with refractory angina: Canadian Cardiovascular Society/Canadian Pain Society joint guidelines. Can J Cardiol 28(2 Suppl):S20–S41
Mejdahl MK, Andersen KG, Gärtner R et al (2013) Persistent pain and sensory disturbances after treatment for breast cancer: six year nationwide follow-up study. BMJ 346:f1865
Peyravi M, Capelle HH, Fischer S et al (2011) Subcutaneous peripheral neurostimulation for the treatment of severe chronic poststernotomy neuralgia. Stereotact Funct Neurosurg 89:253–257
Richter JE (2013) Gastroesophageal reflux disease treatment: side effects and complications of fundoplication. Clin Gastroenterol Hepatol 11:465–471
Schaefert R, Hausteiner-Wiehle C, Häuser W et al (2012) Non-specific, functional, and somatoform bodily complaints. Dtsch Arztebl Int 109:803–813
Schreiber KL, Martel MO, Shnol H et al (2013) Persistent pain in postmastectomy patients: comparison of psychophysical, medical, surgical, and psychosocial characteristics between patients with and without pain. Pain 154:660–668
Sifrim D, Zerbib F (2012) Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors. Gut 61:1340–1354
Task Force Members, Montalescot G, Sechtem U et al (2013) 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J 34:2949–3003
Taylor RS, De Vries J, Buchser E, Dejongste MJ (2009) Spinal cord stimulation in the treatment of refractory angina: systematic review and meta-analysis of randomized controlled trials. BMC Cardiovasc Disord 9:13
Tronnier V, Baron R, Birklein F et al (2011) Epidurale Rückenmarkstimulation zur Therapie chronischer Schmerzen. Zusammenfassung der S3-Leitlinie. Schmerz 25:484–492
Leersum NJ van, Leersum RL van, Verwey HF, Klautz RJ (2010) Pain symptoms accompanying chronic poststernotomy pain: a pilot study. Pain Med 11:1628–1634
Vilholm OJ, Cold S, Rasmussen L, Sindrup SH (2008) Effect of levetiracetam on the postmastectomy pain syndrome. Eur J Neurol 15:851–857
Einhaltung ethischer Richtlinien
Interessenkonflikt. W. H. erhielt ein Beratungshonorar von Daiichi Sankyo und Vortragshonorare von Abbott Deutschland, MSD Sharpe & Dohme und Pfizer in den letzten 3 Jahren. D. G. führt AMTS-Projekte mit der Barmer GEK, Knappschaft-Bahn-See, IKK Südwest und dem Saarländischen Gesundheitsministerium durch. Er ist Mitglied des wissenschaftlichen Beirats von RpDoc Solutions GmbH; D. G. hat keine Interessenkonflikte anzugeben. Der Beitrag enthält keine Studien an Menschen oder Tieren.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Görge, G., Grandt, D. & Häuser, W. Chronischer Brustschmerz. Schmerz 28, 282–288 (2014). https://doi.org/10.1007/s00482-014-1405-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00482-014-1405-7
Schlüsselwörter
- Gastroösophagealer Reflux
- Nichtkardialer Brustschmerz
- Refraktäre Angina pectoris
- Postmastektomiesyndrom
- Poststernotomiesyndrom