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Hepatocellular Carcinoma Arising from Nonalcoholic Steatohepatitis: Report of Two Cases

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Abstract

Sporadic cases of hepatocellular carcinoma (HCC) originating from nonalcoholic steatohepatitis (NASH) have recently been reported. Thus, we investigated the prevalence of NASH in patients with HCC. A review of the clinical records of 481 patients who underwent liver resection for HCC in our department between January 1991 and December 2003 revealed only two (0.4%) patients with HCC associated with NASH. Both of these patients had noninsulin-dependent diabetes mellitus, and neither had a history of alcohol consumption or blood transfusion. All serologic markers for hepatitis B and C viruses were negative. Histological examination of the noncancerous hepatic tissue revealed NASH with moderate hepatic fibrosis in one patient and cirrhosis in the other. Thus, clinical follow-up and screening for HCC should be done for patients with hepatic fibrosis caused by NASH, even though this form of hepatitis is an uncommon cause of HCC.

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Authors and Affiliations

  1. Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan

    Seikan Hai, Shoji Kubo, Taichi Shuto, Hiromu Tanaka, Shigekazu Takemura, Takatsugu Yamamoto, Akishige Kanazawa, Masao Ogawa & Kazuhiro Hirohashi

  2. Department of Clinical Pathology, Osaka City University Hospital, Osaka, Japan

    Kenichi Wakasa

Authors
  1. Seikan Hai
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  2. Shoji Kubo
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  3. Taichi Shuto
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  4. Hiromu Tanaka
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  5. Shigekazu Takemura
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  6. Takatsugu Yamamoto
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  7. Akishige Kanazawa
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  8. Masao Ogawa
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  9. Kazuhiro Hirohashi
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  10. Kenichi Wakasa
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Hai, S., Kubo, S., Shuto, T. et al. Hepatocellular Carcinoma Arising from Nonalcoholic Steatohepatitis: Report of Two Cases. Surg Today 36, 390–394 (2006). https://doi.org/10.1007/s00595-005-3167-4

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  • DOI: https://doi.org/10.1007/s00595-005-3167-4

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