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Non-enzymatic sensing of uric acid using a carbon nanotube ionic-liquid paste electrode modified with poly(β-cyclodextrin)

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Abstract

We describe a nonenzymatic electrochemical sensor for uric acid. It is based on a carbon nanotube ionic-liquid paste electrode modified with poly(β-cyclodextrin) that was prepared in-situ by electropolymerization. The functionalized multi-walled carbon nanotubes and the surface morphology of the modified electrodes were characterized by transmission electronic microscopy and scanning electron microscopy. The electrochemical response of uric acid was studied by cyclic voltammetry and linear sweep voltammetry. The effects of scan rate, pH value, electropolymerization cycles and accumulation time were also studied. Under optimized experimental conditions and at a working voltage of 500 mV vs. Ag/AgCl (3 M KCl), response to uric acid is linear in the 0.6 to 400 μΜ and in the 0.4 to 1 mΜ concentration ranges, and the detection limit is 0.3 μΜ (at an S/N of 3). The electrode was successfully applied to the detection of uric acid in (spiked) human urine samples.

SEM images of (a) carbon ionic liquid electrode (CILE) (b) MWNT-CILE (c) β-CD/CILE (d) β-CD/ MWNT-CILE. The surfaces of carbon ionic liquid electrode (CILE) (a) and MWNT-CILE (b) were homogenous and no separated carbon layers can be observed; After β- cyclodextrin (CD) was modified on CILE and MWNT-CILE, the surfaces of β-CD modified electrodes (c and d) exhibited loose and porous morphologies.

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Acknowledgments

This research was supported by the Ningxia Higher School Scientific Research Project (No. NGY2013080).

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Authors and Affiliations

  1. School of Public Health, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China

    Yonghong Li, Xiaoling Ji, Ling Wang & Hongyan Qiu

  2. Department of Chemistry and Chemical Engineering, Jining University, Qufu, 273155, People’s Republic of China

    Xiurong Zhai

  3. College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang, 464000, People’s Republic of China

    Haibo Wang

  4. Higher Vocational Technical School, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China

    Xinsheng Liu

  5. School of Laboratory Medicine, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China

    Le Guo

  6. College of Science, Hunan Agriculture University, Changsha, 410128, People’s Republic of China

    Xiaoying Liu

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  1. Yonghong Li
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  2. Xiurong Zhai
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  7. Ling Wang
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  9. Xiaoying Liu
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Correspondence to Yonghong Li or Xinsheng Liu.

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Li, Y., Zhai, X., Wang, H. et al. Non-enzymatic sensing of uric acid using a carbon nanotube ionic-liquid paste electrode modified with poly(β-cyclodextrin). Microchim Acta 182, 1877–1884 (2015). https://doi.org/10.1007/s00604-015-1522-8

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  • DOI: https://doi.org/10.1007/s00604-015-1522-8

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