Abstract
Electrochemical DNA sensors represent a simple, accurate and economical platform for DNA detection. Gold nanoparticles are known to be efficient labels in electrochemical sensors and to be viable materials to modify the surface of electrodes thereby to enhance the detection limit of the sensor. For surface modification, gold nanoparticles are used in combination with nanomaterials like graphene, graphene oxide, or carbon nanotubes to improve electrochemical performance in general. This review (with 116 refs.) mainly covers the advances made in recent years in the use of gold nanoparticles in DNA sensing. It is divided into the following main sections: (a) An introduction covers aspects of electrochemical sensing of DNA and of appropriate nanomaterials in general. (b) The use of gold nanoparticles in DNA is specifically addressed next, with subsections on AuNPs acting as electrochemical labels, electron transfer mediators, signal amplifiers, carriers of electroactive molecules, catalysts, immobilization platforms, on silver enhancement strategies, on AuNPs modified with carbonaceous materials (such as graphenes and nanotubes), and on multiple amplification schemes. The review concludes with a discussion of current challenges and trends in terms of highly sensitive DNA based sensing using AuNPs.
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References
He P, Xu Y, Fang Y (2005) A review: electrochemical DNA Biosensorsfor sequence recognition. Anal Lett 38(15):2597–2623
Paleček E, Jelen F (2002) Electrochemistry of nucleic acids and development of DNASensors. Crit Rev Anal Chem 32(3):261–270
Lucarelli F, Tombelli S, Minunni M, Marrazza G, Mascini M (2008) Electrochemical and piezoelectric DNA biosensors for hybridisation detection. Anal Chim Acta 609(2):139–159
Fojta M (2002) Electrochemical sensors for DNA interactions and damage. Electroanal 14(21):1449–1463
Diculescu VC, Paquim AC, Brett AMO (2005) Electrochemical DNA sensors for detection of DNA damage. Sensors 5(6):377–393
Liu G, Wan Y, Gau V, Zhang J, Wang L, Song S, Fan C (2008) An enzyme-based E-DNA sensor for sequence-specific detection of femtomolar DNA targets. J Am Chem Soc 130(21):6820–6825
Grabowska I, Singleton DG, Stachyra A, Gòra-Sochacka A, Sirko A, Zagòrski-Ostoja W, Radecka H, Stulz E, Radecki J (2014) A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA. Chem Commun 50(32):4196–4199
Drummond TG, Hill MG, Barton JK (2003) Electrochemical DNA sensors. Nat Biotechnol 21(10):1192–1199
Wang J (2006) Electrochemical biosensors: towards point-of-care cancer diagnostics. Biosens Bioelectron 21(10):1887–1892
Hu Q, Hu W, Kong J, Zhang X (2015) PNA-based DNA assay with attomolar detection limit based on polygalacturonic acid mediated in-situ deposition of metallic silver on a gold electrode. Microchim Acta 182(1–2):427–434
Feng L, Chen Y, Ren J, Qu X (2011) A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cells. Biomaterials 32(11):2930–2937
Jayakumar K, Rajesh R, Dharuman V, Venkatasan R, Hahn JH, Pandian SK (2012) Gold nanoparticle decorated graphene core first generation PAMAM dendrimers for label free electrochemical DNA hybridization sensing. Biosens Bioelectron 31(1):406–412
Li C, Karadeniz H, Canavar E, Erdem A (2012) Electrochemical sensing of label free DNA hybridization related to breast cancer 1 gene at disposable sensor platforms modified with single walled carbon nanotubes. Electrochim Acta 82:137–142
García-Mendiola T, Gamero M, Campuzano S, Revenga-Parra M, Alonso C, Pedrero M, Pariente F, Pingarrón JM, Lorenzo E (2013) Nanostructured rough gold electrodes as platforms to enhance the sensitivity of electrochemical genosensors. Anal Chim Acta 788:141–147
Zhu C, Yang G, Li H, Du D, Lin Y (2015) Electrochemical sensors and biosensors based on nanomaterials and nanostructures. Anal Chem 87(1):230–249
Kurkina T, Vlandas A, Ahmad A, Kern K, Balasubramanian K (2011) Label-free detection of few copies of DNA with carbon nanotube impedance biosensors. Angew Chem Int Ed 50(16):3710–3714
Gill R, Zayats M, Willner I (2008) Semiconductor quantum dots for bioanalysis. Angew Chem Int Ed 47(40):7602–7625
Liu HY, Johnston APR (2013) A programmable sensor to probe the internalization of proteins and nanoparticles in live cells. Angew Chem Int Ed 52(22):5744–5748
Wu L, Xiong E, Zhang X, Zhang X, Chen J (2014) Nanomaterials as signal amplification elements in DNA-based electrochemical sensing. Nano Today 9(2):197–211
Wang J (2005) Nanomaterial-based electrochemical biosensors. Analyst 130(4):421–426
Kerman K, Saito M, Yamamura S, Takamura Y, Tamiya E (2008) Nanomaterial-based electrochemical biosensors for medical applications. TRAC Trend Anal Chem 27(7):585–592
Holzinger M, Goff AL, Cosnier S (2014) Nanomaterials for biosensing applications: a review. Front Chem 2:63
Cao X, Ye Y, Liu S (2011) Gold nanoparticle-based signal amplification for biosensing. Anal Biochem 417(1):1–16
Saha K, Agasti SS, Kim C, Li X, Rotello VM (2012) Gold nanoparticles in chemical and biological sensing. Chem Rev 112(5):2739–2779
Ensafi AA, Taei M, Rahmani HR, Khayamian T (2011) Sensitive DNA impedance biosensor for detection of cancer, chronic lymphocytic leukemia, based on gold nanoparticles/gold modified electrode. Electrochim Acta 56(24):8176–8183
Oh JH, Lee JS (2011) Designed hybridization properties of DNA-gold nanoparticle conjugates for the ultraselective detection of a single-base mutation in the breast cancer gene BRCA1. Anal Chem 83(19):7364–7370
Shi A, Wang J, Han X, Fang X, Zhang Y (2014) A sensitive electrochemical DNA biosensor based on gold nanomaterial and graphene amplified signal. Sensor Actuat B-Chem 200:206–212
Radhakrishnan S, Sumathi C, Dharuman V, Wilson J (2012) Gold nanoparticles functionalized poly(3,4-ethylenedioxythiophene) thin film for highly sensitive label free DNA detection. Anal Methods 5(3):684–689
Zhang Y, Huang L (2012) Label-free electrochemical DNA biosensor based on a glassy carbon electrode modified with gold nanoparticles, polythionine and graphene. Microchim Acta 176(3–4):463–470
Castaneda MT, Alegret S, Merkoai A (2007) Electrochemical sensing of DNA using gold nanoparticles. Electroanal 19(7):743–753
Li Y, Schluesener HJ, Xu S (2010) Gold nanoparticle-based biosensors. Gold Bull 43(1):29–41
Pingarrón JM, Yañez-Sedeño P, González-Cortés A (2008) Gold nanoparticle-based electrochemical biosensors. Electrochim Acta 53(19):5848–5866
Hutter E, Maysinger D (2013) Gold-nanoparticle-based biosensors for detection of enzyme activity. Trends Pharmacol Sci 34(9):497–507
Lepoitevin M, Lemouel M, Bechelany M, Janot JM, Balme S (2015) Gold nanoparticles for the bare-eye based and spectrophotometric detection of proteins, polynucleotides and DNA. Microchim Acta 182(5–6):1223–1229
Jang H, Kwak CH, Kim G, Kim SM, Huh YS, Jeon TJ (2016) Identification of genetically modified DNA found in roundup ready soybean using gold nanoparticles. Microchim Acta 183(9):2649–2654
Lu L, Wu J, Li M, Kang T, Cheng S (2015) Detection of DNA damage by exploiting the distance dependence of the electrochemiluminescence energy transfer between quantum dots and gold nanoparticles. Microchim Acta 182(1–2):233–239
Azizah N, Hashim U, Gopinath SC, Nadzirah S (2016) Gold nanoparticle mediated method for spatially resolved deposition of DNA on nano-gapped interdigitated electrodes, and its application to the detection of the human papillomavirus. Microchim Acta 183(12):3119–3126
Niemeyer CM, Simon U (2005) DNA-based assembly of metal nanoparticles. Eur J Inorg Chem 2005(18):3641–3655
Elghanian R, Storhoff JJ, Mucic RC, Letsinger RL, Mirkin CA (1997) Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. Science 277(5329):1078–1081
Tan LH, Xing H, Chen H, Lu Y (2013) Facile and efficient preparation of anisotropic DNA functionalized gold nanoparticles and their regioselective assembly. J Am Chem Soc 135(47):17675–17678
Fratila RM, Mitchell SG, Pino PD, Grazu V, de la Fuente JM (2014) Strategies for the biofunctionalization of gold and iron oxide nanoparticles. Langmuir 30(50):15057–15071
Wang H, Wang D, Peng Z, Tang W, Li N, Liu F (2013) Assembly of DNA-functionalized gold nanoparticles on electrospun nanofibers as a fluorescent sensor for nucleic acids. Chem Commun 49(49):5568–5570
Xu M, Zhuang J, Chen X, Chen G, Tang D (2013) A difunctional DNA-AuNP dendrimer coupling DNAzyme with intercalators for femtomolar detection of nucleic acids. Chem Commun 49(66):7304–7306
Wang Z, Zhang J, Zhu C, Wu S, Mandler D, Marks RS, Zhang H (2014) Amplified detection of femtomolar DNA based on a one-to-few recognition reaction between DNA-Au conjugate and target DNA. Nanoscale 6(6):3110–3115
Fei W, Zhang Y, Sun X, Zhang Y, Cao H, Shen H, Jia N (2012) Direct electrochemistry and electrocatalysis of myoglobin immobilized on DNA-gold nanoparticle clusters composite film. J Electroanal Chem 675:5–10
Yang Y, Li C, Yin L, Liu M, Wang Z, Shu Y, Li G (2014) Enhanced charge transfer by gold nanoparticle at DNA modified electrode and its application to label-free DNA detection. ACS Appl Mater Interfaces 6(10):7579–7584
Gao Q, Zhang W, Guo Y, Qi H, Zhang C (2013) Highly sensitive impedimetric sensing of DNA hybridization based on the target DNA-induced displacement of gold nanoparticles attached to ssDNA probe. Electrochem Commun 13(4):335–337
Wang C, Yuan X, Liu X, Gao Q, Qi H, Zhang C (2013) Signal-on impedimetric electrochemical DNA sensor using dithiothreitol modified gold nanoparticle tag for highly sensitive DNA detection. Anal Chim Acta 799:36–43
Li Z, Miao X, Xing K, Zhu A, Ling L (2015) Enhanced electrochemical recognition of double-stranded DNA by using hybridization chain reaction and positively charged gold nanoparticles. Biosens Bioelectron 74:687–690
Rasheed PA, Sandhyarani N (2014) Femtomolar level detection of BRCA1 gene using gold nanoparticle labeled sandwich type DNA sensor. Colloids Surf B: Biointerfaces 117:7–13
Rasheed PA, Sandhyarani N (2015) Attomolar detection of BRCA1 gene based on gold nanoparticle assisted signal amplification. Biosens Bioelectron 65:333–340
Mathew M, Sandhyarani N (2014) Distance dependent sensing capabilities of enzymatic biosensor surface constructed with gold nanoparticle immobilized on self assembled monolayer modified gold electrode. Sens Lett 12(8):1286–1294
Wang W, Yuan X, Liu X, Gao Q, Qi H, Zhang C (2013) Selective DNA detection at zeptomole level based on coulometric measurement of gold nanoparticle-mediated electron transfer across a self-assembled monolayer. SCIENCE CHINA Chem 56(7):1009–1016
Li S, Qiu W, Zhang X, Ni J, Gao F, Wang Q (2016) A high-performance DNA biosensor based on the assembly of gold nanoparticles on the terminal of hairpin-structured probe DNA. Sensor Actuat B-Chem 223:861–867
Liu G, Lin Y (2007) Electrochemical quantification of single-mucleotide polymorphisms using nanoparticle probes. J Am Chem Soc 129(34):10394–10401
Sun AL, Zhang YF, Wang XN (2015) Sensitive voltammetric determination of DNA via a target-induced strand-displacement reaction using quantum dot-labeled probe DNA. Microchim Acta 182(7–8):1403–1410
March G, Nguyen TD, Piro B (2015) Modified electrodes used for electrochemical detection of metal ions in environmental analysis. Biosensors 5(2):241–275
Kuan GC, Sheng LP, Rijiravanich P, Marimuthu K, Ravichandran M, Yin LS, Lertanantawong B, Surareungchai W (2013) Gold-nanoparticle based electrochemical DNA sensor for the detection of fish pathogen Aphanomyces invadans. Talanta 117:312–317
Rasheed PA, Sandhyarani N (2014) Graphene-DNA electrochemical sensor for the sensitive detection of BRCA1 gene. Sensor Actuat B-Chem 204:777–782
Rasheed PA, Sandhyarani N (2015) A highly sensitive DNA sensor for attomolar detection of BRCA1 gene: signal amplification with gold nanoparticle cluster. Analyst 140:2713–2718
Rasheed PA, Radhakrishnan T, Shihabudeen PK, Sandhyrani N (2016) Reduced graphene oxide-yttria nanocomposite modified electrode for enhancing the sensitivity of electrochemical genosensors. Biosens Bioelectron 83:361–367
Zheng J, Chen C, Wang X, Zhang F, He P (2014) A sequence-specific DNA sensor for hepatitis B virus diagnostics based on the host-guest recognition. Sensor Actuat B-Chem 199:168–174
Pumera M, Castañeda MT, Pividori MI, Eritja R, Merkoçi A, Alegret S (2005) Magnetically trigged direct electrochemical detection of DNA hybridization using Au67 quantum dot as electrical tracer. Langmuir 21(21):9625–9629
Kawde AN, Wang J (2004) Amplified electrical transduction of DNA hybridization based on polymeric beads loaded with multiple gold nanoparticle tags. Electroanal 16(1–2):101–107
Zhang J, Song S, Zhang L, Wang L, Wu H, Pan D, Fan C (2006) Sequence-specific detection of femtomolar DNA via a chronocoulometric DNA sensor (CDS): effects of nanoparticle-mediated amplification and nanoscale control of DNA assembly at electrodes. J Am Chem Soc 128(26):8575–8580
Fang X, Jiang W, Han X, Zhang Y (2013) Molecular beacon based biosensor for the sequence-specific detection of DNA using DNA-capped gold nanoparticles-streptavidin conjugates for signal amplification. Microchim Acta 180(13–14):1271–1277
Bonanni A, Esplandiu MJ, del Valle M (2008) Signal amplification for impedimetric genosensing using gold-streptavidin nanoparticles. Electrochim Acta 53(11):4022–4029
Fang X, Bai L, Han X, Wang J, Shi A, Zhang Y (2014) Ultra-sensitive biosensor for K-ras gene detection using enzyme capped gold nanoparticles conjugates for signal amplification. Anal Biochem 460:47–53
Cao X (2014) Ultra-sensitive electrochemical DNA biosensor based on signal amplification using gold nanoparticles modified with molybdenum disulfide, graphene and horseradish peroxidase. Microchim Acta 181(9–10):1133–1141
Cui HF, Xu TB, Sun YL, Zhou AW, Cui YH, Liu W, Luong JHT (2015) Hairpin DNA as a biobarcode modified on gold nanoparticles for electrochemical DNA detection. Anal Chem 87:1358–1365
Mucic RC, Herrlein MK, Mirkin CA, Letsinger RL (1996) Synthesis and characterization of DNA with ferrocenyl groups attached to their 5′-termini: electrochemical characterization of a redox-active nucleotide monolayer. Chem Commun 1(4):555–557
Wang J, Polsky R, Merkoci A, Turner KL (2003) Electroactive beads for ultrasensitive DNA detection. Langmuir 19(4):989–991
Patolsky F, Weizmann Y, Willner I (2002) Redox-active nucleic-acid replica for the amplified bioelectrocatalytic detection of viral DNA. J Am Chem Soc 124(5):770–772
Wang JL, Munir A, Li ZH, Zhou HS (2010) Aptamer-AuNPs conjugates-accumulated methylene blue for the sensitive electrochemical immunoassay of protein. Talanta 81:63–67
Rohs R, Sklenar H, Lavery R, Röder B (2000) Methylene blue binding to DNA with alternating GC base sequence: a modeling study. J Am Chem Soc 122(12):2860–2866
Zhu LM, Luo LQ, Wang ZX (2012) DNA electrochemical biosensor based on thionine-graphene nanocomposite. Biosens Bioelectron 35:507–511
Dohno C, Stemp EDA, Barton JK (2003) Fast back electron transfer prevents guanine damage by photoexcited thionine bound to DNA. J Am Chem Soc 125:9586–9587
Liu SN, Wu P, Li W, Zhang H, Cai CX (2011) Ultrasensitive and selective electrochemical identification of hepatitis C virus genotype 1b based on specific endonuclease combined with gold nanoparticles signal amplification. Anal Chem 83:4752–4758
Zhang XA, Teng YQ, Fu Y, Xu LL, Zhang SP, He B, Wang CG, Zhang W (2010) Lectin-based biosensor strategy for electrochemical assay of glycan expression on living cancer cells. Anal Chem 82:9455–9460
Wang J, Li J, Baca AJ, Hu J, Zhou F, Yan W, Pang D (2003) Amplified voltammetric detection of DNA hybridization via oxidation of ferrocene caps on gold nanoparticle/streptavidin conjugates. Anal Chem 75(15):3941–3945
Baca AJ, Zhou F, Wang J, Hu J, Li J, Wang J, Chikneyan ZS (2004) Attachment of ferrocene-capped gold nanoparticle/streptavidin conjugates onto electrode surfaces covered with biotinylated biomolecules for enhanced voltammetric analysis. Electroanal 16(12):73–80
Qiu L, Qiu L, Wu ZS, Shen G, Yu RQ (2013) Cooperative amplification-based electrochemical sensor for the zeptomole detection of nucleic acids. Anal Chem 85(17):8225–8231
Qiu L, Qiu L, Zhou H, Wu Z, Shen G, Yu R (2014) Sensitive and selective electrochemical DNA sensor for the analysis of cancer-related single nucleotide polymorphism. New J Chem 38(10):4711–4715
Cui H, Cheng L, Zhang J, Liu R, Zhang C, Fan H (2014) An electrochemical DNA sensor for sequence-specific DNA recognization in a homogeneous solution. Biosens Bioelectron 56:124–128
Kong RM, Song ZL, Meng HM, Zhang XB, Shen GL, Yu RQ (2014) A label-free electrochemical biosensor for highly sensitive and selective detection of DNA via a dual-amplified strategy. Biosens Bioelectron 54:442–447
Wang W, Song L, Gao Q, Qi H, Zhang C (2013) Highly sensitive detection of DNA using an electrochemical DNA sensor with thionine-capped DNA/gold nanoparticle conjugates as signal tags. Electrochem Commun 34:18–21
Liu X, Zhang R, Liu L, Zhou Y, Gao Q (2014) Highly sensitive voltammetric detection of DNA hybridization in sandwich format using thionine-capped gold nanoparticle/reporter DNA conjugates as signal tags. Gold Bull 47(1):119–125
Das J, Aziz MA, Yang H (2006) A nanocatalyst based assay for proteins: DNA free ultrasensitive electrochemical detection using catalytic reduction of p-nitrophenol by gold nanoparticle labels. J Am Chem Soc 128:16022–16023
Liu J, Tian M, Liang Z (2013) DNA analysis based on the electrocatalytic amplification of gold nanoparticles. Electrochim Acta 113:186–193
Lin L, Liu Y, Tang L, Li J (2011) Electrochemical DNA sensor by the assembly of graphene and DNA-conjugated gold nanoparticles with silver enhancement strategy. Analyst 136(22):4732–4737
Gao F, Zhu Z, Lei J, Geng Y, Ju X (2013) Sub-femtomolar electrochemical detection of DNA using surface circular strand-replacement polymerization and gold nanoparticle catalyzed silver deposition for signal amplification. Biosens Bioelectron 39:199–203
Ye WW, Shi JY, Chan CY, Zhang Y, Yang M (2014) A nanoporous membrane based impedance sensing platform for DNA sensing with gold nanoparticle amplification. Sensor Actuat B-Chem 193:877–882
Zhang Q, Dai P, Yang Z (2011) Sensitive DNA-hybridization biosensors based on gold nanoparticles for testing DNA damage by Cd(II) ions. Microchim Acta 173:347–352
Yin ZJ, Wu JJ, Yang ZS (2010) A sensitive mercury (II) sensor based on CuO nanoshuttles/poly(thionine) modified glassy carbon electrode. Microchim Acta 170:307–312
Zhao K, Song HY, Zhuang SQ, Dai LM, He PG, Fang YZ (2007) Determination of nitrite with the electrocatalytic property to the oxidation of nitrite on thionine modified aligned carbon nanotubes. Electrochem Commun 9:65–70
Gao Q, Cui XQ, Yang F, Ma Y, Yang XR (2003) Preparation of poly(thionine) modified screen-printed carbon electrode and its application to determine NADH in flow injection analysis system. Biosens Bioelectron 19:277–282
Owino JHO, Arotiba OA, Hendricks N, Songa EA, Jahed N, Waryo TT, Ngece RF, Baker PGL, Iwuoha EI (2008) Electrochemical immunosensor based on polythionine/gold nanoparticles for the determination of aflatoxin B1. Sensors 8:8262–8274
Wang L, Hua E, Liang M, Ma C, Liu Z, Sheng S, Liu M, Xie G, Feng W (2014) Graphene sheets, polyaniline and AuNPs based DNA sensor for electrochemical determination of BCR/ABL fusion gene with functional hairpin probe. Biosens Bioelectron 51:201–207
Huang H, Bai W, Dong C, Guo R, Liu Z (2015) An ultrasensitive electrochemical DNA biosensor based on graphene/Au nanorod/polythionine for human papilloma virus DNA detection. Biosens Bioelectron 68:442–446
Xu CX, Zhai QG, Liu YJ, Huang KJ, Lu L, Li KX (2014) A novel electrochemical DNA biosensor construction based on layered CuS-graphene composite and Au nanoparticles. Anal Bioanal Chem 406(27):6943–6951
Huang K, Liu Y, Wang H, Gan T, Liu Y, Wang L (2014) Signal amplification for electrochemical DNA biosensor based on two-dimensional graphene analogue tungsten sulphide-graphene composites and gold nanoparticles. Sensor Actuat B-Chem 191:828–836
Yola ML, Eren T, Atar N (2014) A novel and sensitive electrochemical DNA biosensor based on Fe@Au nanoparticles decorated graphene oxide. Electrochim Acta 125:38–47
Zhang Y, Jiang W (2012) Decorating graphene sheets with gold nanoparticles for the detection of sequence-specific DNA. Electrochim Acta 71:239–245
Wang J, Shi A, Fang X, Han X, Zhang Y (2014) Ultrasensitive electrochemical supersandwich DNA biosensor using a glassy carbon electrode modified with gold particle-decorated sheets of graphene oxide. Microchim Acta 181(9–10):935–940
Chen M, Hou C, Huo D, Bao J, Fa H, Shen C (2016) An electrochemical DNA biosensor based on nitrogen-doped graphene/Au nanoparticles for human multidrug resistance gene detection. Biosens Bioelectron 85:684–691
Gupta VK, Yola ML, Qureshi MS, Solak AO, Atar N, Üstündağ Z (2013) A novel impedimetric biosensor based on graphene oxide/gold nanoplatform for detection of DNA arrays. Sensor Actuat B-Chem 188:1201–1211
Peng H, Hu Y, Liu P, Deng Y, Wang P, Chen Y, Lin X (2015) Label-free electrochemical DNA biosensor for rapid detection of multidrug resistance gene based on Au nanoparticles/toluidine blue-graphene oxide nanocomposites. Sensor Actuat B-Chem 207:269–276
Benvidi A, Firouzabadi AD, Moshtaghiun SM, Mazloum-Ardakani M, Tezerjani MD (2015) Ultrasensitive DNA sensor based on gold nanoparticles/reduced graphene oxide/glassy carbon electrode. Anal Biochem 484:24–30
Hajihosseini S, Nasirizadeh N, Hejazi MS, Yaghmaei P (2016) A sensitive DNA biosensor fabricated from gold nanoparticles and graphene oxide on a glassy carbon electrode. Mater Sc Eng C 61:506–515
Ye Y, Gao J, Zhuang H, Zheng H, Sun H, Ye Y, Xu X, Cao X (2017) Electrochemical gene sensor based on a glassy carbon electrode modified with hemin-functionalized reduced graphene oxide and gold nanoparticle-immobilized probe DNA. Microchim Acta 184(1):245–252
Zhang Y, Wang J, Xu M (2010) A sensitive DNA biosensor fabricated with gold nanoparticles/ploy (p-aminobenzoic acid)/carbon nanotubes modified electrode. Colloids Surf B: Biointerfaces 75(1):179–185
Fayazfar H, Afshar A, Dolati M, Dolati A (2014) DNA impedance biosensor for detection of cancer, TP53 gene mutation, based on gold nanoparticles/aligned carbon nanotubes modified electrode. Anal Chim Acta 836:34–44
Li L, Wang S, Yang T, Huang S, Wang J (2012) Electrochemical growth of gold nanoparticles on horizontally aligned carbon nanotubes: a new platform for ultrasensitive DNA sensing. Biosens Bioelectron 33:279–283
Dong X, Lu X, Zhang K, Zhang Y (2013) Chronocoulometric DNA biosensor based on a glassy carbon electrode modified with gold nanoparticles, poly(dopamine) and carbon nanotubes. Microchim Acta 180(1–2):101–108
Huang KJ, Liu YJ, Zhang JZ, Liu YM (2015) A sequence-specific DNA electrochemical sensor based on acetylene black incorporated two-dimensional CuS nanosheets and gold nanoparticles. Sensor Actuat B-Chem 209:570–578
Liu C, Jiang D, Xian G, Liu L, Liu F, Pu X (2014) An electrochemical DNA biosensor for the detection of mycobacterium tuberculosis, based on signal amplification of graphene and a gold nanoparticle-polyaniline nanocomposite. Analyst 139(21):5460–5465
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The authors acknowledge Council of Scientific and Industrial Research and Department of Science and Technology of Government of India for the financial support to the Nano Science Research Laboratory.
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Rasheed, P.A., Sandhyarani, N. Electrochemical DNA sensors based on the use of gold nanoparticles: a review on recent developments. Microchim Acta 184, 981–1000 (2017). https://doi.org/10.1007/s00604-017-2143-1
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DOI: https://doi.org/10.1007/s00604-017-2143-1