Skip to main content
SpringerLink
Log in

Nanomaterial-based biosensors for detection of prostate specific antigen

  • Review Article
  • Published:
Microchimica Acta Aims and scope Submit manuscript

Abstract

Screening serum for the presence of prostate specific antigen (PSA) belongs to the most common approach for the detection of prostate cancer. This review (with 156 refs.) addresses recent developments in PSA detection based on the use of various kinds of nanomaterials. It starts with an introduction into the field, the significance of testing for PSA, and on current limitations. A first main section treats electrochemical biosensors for PSA, with subsections on methods based on the use of gold electrodes, graphene or graphene-oxide, carbon nanotubes, hybrid nanoparticles, and other types of nanoparticles. It also covers electrochemical methods based on the enzyme-like activity of PSA, on DNA-, aptamer- and biofuel cell-based methods, and on the detection of PSA via its glycan part. The next main section covers optical biosensors, with subsections on methods making use of surface plasmon resonance (SPR), localized SPR and plasmonic ELISA-like schemes. This is followed by subsections on methods based on the use of fiber optics, fluorescence, chemiluminescence, Raman scattering and SERS, electrochemiluminescence and cantilever-based methods. The most sensitive biosensors are the electrochemical ones, with lowest limits of detection (down to attomolar concentrations), followed by mass cantilever sensing and electrochemilumenescent strategies. Optical biosensors show lower performance, but are still more sensitive compared to standard ELISA. The most commonly applied nanomaterials are metal and carbon-based ones and their hybrid composites used for different amplification strategies. The most attractive sensing schemes are summarized in a Table. The review ends with a section on conclusions and perspectives.

Schematic representation of nanostructure-based biosensors for detection of prostate specific antigen using various detection schemes and biorecognition elements such as antibodies (Abs), aptamers (APT), lectins (LEC), and molecularly imprinted polymers (MIP).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Scheme 1
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H, Forman D, Bray F (2013) Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur J Cancer 49(6):1374–1403

    Article  CAS  Google Scholar 

  2. Bray F, Kiemeney LA (2017) Epidemiology of Prostate Cancer in Europe: Patterns, Trends and Determinants. In: Management of Prostate Cancer. Springer, pp 1–27

  3. Mokdad AH, Dwyer-Lindgren L, Fitzmaurice C, Stubbs RW, Bertozzi-Villa A, Morozoff C, Charara R, Allen C, Naghavi M, Murray CJ (2017) Trends and patterns of disparities in cancer mortality among US counties, 1980-2014. JAMA 317(4):388–406

    Article  Google Scholar 

  4. Prostate cancer (2015). http://www.nhs.uk/Conditions/Cancer-of-the-prostate/Pages/Introduction.aspx

  5. Miller DC, Hafez KS, Stewart A, Montie JE, Wei JT (2003) Prostate carcinoma presentation, diagnosis, and staging: an update form the National Cancer Data Base. Cancer 98(6):1169–1178

    Article  Google Scholar 

  6. Mottet N, Bellmunt J, Bolla M, Briers E, Cumberbatch MG, De Santis M, Fossati N, Gross T, Henry AM, Joniau S, Lam TB, Mason MD, Matveev VB, Moldovan PC, van den Bergh RCN, Van den Broeck T, van der Poel HG, van der Kwast TH, Rouvière O, Schoots IG, Wiegel T, Cornford P (2017) EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur Urol 71(4):618–629

    Article  Google Scholar 

  7. Parpart S, Rudis A, Schreck A, Dewan N, Warren P (2007) Sensitivity and specificity in prostate cancer screening methods and strategies. J Young Invest http://www.jyi.org/issue/sensitivity-and-specificity-in-prostate-cancer-screening-methods-and-strategies/

    Google Scholar 

  8. Wolf AM, Wender RC, Etzioni RB, Thompson IM, D'Amico AV, Volk RJ, Brooks DD, Dash C, Guessous I, Andrews K, DeSantis C, Smith RA (2010) American Cancer Society guideline for the early detection of prostate cancer: update 2010. CA Cancer J Clin 60(2):70–98

    Article  Google Scholar 

  9. Stamey TA, Yang N, Hay AR, McNeal JE, Freiha FS, Redwine E (1987) Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 317(15):909–916

    Article  CAS  Google Scholar 

  10. Hara M, Inoue T, Koyanagi Y, Fukuyama T, Iki H (1969) Immunochemical characteristics of human specific component “γ-Sm”. Nippon Hoigaku Zasshi 23:333

    Google Scholar 

  11. Oesterling JE (1991) Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J Urol 145(5):907–923

    Article  CAS  Google Scholar 

  12. Yousef GM, Diamandis EP (2001) The new human tissue kallikrein gene family: structure, function, and association to disease. Endocr Rev 22(2):184–204

    CAS  Google Scholar 

  13. Jolly P, Tamboli V, Harniman RL, Estrela P, Allender CJ, Bowen JL (2016) Aptamer–MIP hybrid receptor for highly sensitive electrochemical detection of prostate specific antigen. Biosens Bioelectron 75:188–195

    Article  CAS  Google Scholar 

  14. Oesterling JE, Jacobsen SJ, Chute CG, Guess HA, Girman CJ, Panser LA, Lieber MM (1993) Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference ranges. JAMA 270(7):860–864

    Article  CAS  Google Scholar 

  15. Ito K, Yamamoto T, Ohi M, Kurokawa K, Suzuki K, Yamanaka H (2003) Free/total PSA ratio is a powerful predictor of future prostate cancer morbidity in men with initial PSA levels of 4.1 to 10.0 ng/mL. Urology 61(4):760–764

    Article  Google Scholar 

  16. Catalona WJ, Partin AW, Slawin KM, Brawer MK, Flanigan RC, Patel A, Richie JP, deKernion JB, Walsh PC, Scardino PT, Lange PH, Subong EN, Parson RE, Gasior GH, Loveland KG, Southwick PC (1998) Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial. JAMA 279(19):1542–1547

    Article  CAS  Google Scholar 

  17. Velonas VM, Woo HH, dos Remedios CG, Assinder SJ (2013) Current Status of Biomarkers for Prostate Cancer. Int J Mol Sci 14(6):11034–11060

    Article  CAS  Google Scholar 

  18. Sharma S, Zapatero-Rodríguez J, O'Kennedy R (2017) Prostate cancer diagnostics: Clinical challenges and the ongoing need for disruptive and effective diagnostic tools. Biotechnol Adv 35(2):135–149

    Article  Google Scholar 

  19. Shan J, Ma Z (2017) A review on amperometric immunoassays for tumor markers based on the use of hybrid materials consisting of conducting polymers and noble metal nanomaterials. Microchim Acta 184:969–979

    Article  CAS  Google Scholar 

  20. Paleček E, Tkáč J, Bartošík M, Ts B, Ostatná V, Paleček J (2015) Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics. Chem Rev 115(5):2045–2108

    Article  CAS  Google Scholar 

  21. Labib M, Sargent EH, Kelley SO (2016) Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules. Chem Rev 116(16):9001–9090

    Article  CAS  Google Scholar 

  22. Rackus DG, Shamsi MH, Wheeler AR (2015) Electrochemistry, biosensors and microfluidics: a convergence of fields. Chem Soc Rev 44(15):5320–5340

    Article  CAS  Google Scholar 

  23. Grieshaber D, MacKenzie R, Vörös J, Reimhult E (2008) Electrochemical Biosensors - Sensor Principles and Architectures. Sensors (Basel, Switzerland) 8(3):1400–1458

    Article  CAS  Google Scholar 

  24. Uludag Y, Narter F, Sağlam E, Köktürk G, Gök MY, Akgün M, Barut S, Budak S (2016) An integrated lab-on-a-chip-based electrochemical biosensor for rapid and sensitive detection of cancer biomarkers. Anal Bioanal Chem 408(27):7775–7783

    Article  CAS  Google Scholar 

  25. Schumacher S, Nestler J, Otto T, Wegener M, Ehrentreich-Forster E, Michel D, Wunderlich K, Palzer S, Sohn K, Weber A, Burgard M, Grzesiak A, Teichert A, Brandenburg A, Koger B, Albers J, Nebling E, Bier FF (2012) Highly-integrated lab-on-chip system for point-of-care multiparameter analysis. Lab Chip 12(3):464–473

    Article  CAS  Google Scholar 

  26. Pandey B, Demchenko AV, Stine KJ (2012) Nanoporous gold as a solid support for protein immobilization and development of an electrochemical immunoassay for prostate specific antigen and carcinoembryonic antigen. Microchim Acta 179(1):71–81

    Article  CAS  Google Scholar 

  27. Tian J, Huang J, Zhao Y, Zhao S (2012) Electrochemical immunosensor for prostate-specific antigen using a glassy carbon electrode modified with a nanocomposite containing gold nanoparticles supported with starch-functionalized multi-walled carbon nanotubes. Microchim Acta 178(1):81–88

    Article  CAS  Google Scholar 

  28. Yang J, Wen W, Zhang X, Wang S (2015) Electrochemical immunosensor for the prostate specific antigen detection based on carbon nanotube and gold nanoparticle amplification strategy. Microchim Acta 182(9):1855–1861

    Article  CAS  Google Scholar 

  29. Uludag Y, Köktürk G (2015) Determination of prostate-specific antigen in serum samples using gold nanoparticle based amplification and lab-on-a-chip based amperometric detection. Microchim Acta 182(9):1685–1691

    Article  CAS  Google Scholar 

  30. Wang Y, Qu Y, Liu G, Hou X, Huang Y, Wu W, Wu K, Li C (2015) Electrochemical immunoassay for the prostate specific antigen using a reduced graphene oxide functionalized with a high molecular-weight silk peptide. Microchim Acta 182(11):2061–2067

    Article  CAS  Google Scholar 

  31. Zhao J, Guo Z, Feng D, Guo J, Wang J, Zhang Y (2015) Simultaneous electrochemical immunosensing of alpha-fetoprotein and prostate specific antigen using a glassy carbon electrode modified with gold nanoparticle-coated silica nanospheres and decorated with Azure A or ferrocenecarboxylic acid. Microchim Acta 182(15):2435–2442

    Article  CAS  Google Scholar 

  32. Gutiérrez-Zúñiga GG, Hernández-López JL (2016) Sensitivity improvement of a sandwich-type ELISA immunosensor for the detection of different prostate-specific antigen isoforms in human serum using electrochemical impedance spectroscopy and an ordered and hierarchically organized interfacial supramolecular architecture. Anal Chim Acta 902:97–106

    Article  CAS  Google Scholar 

  33. Liu B, Lu L, Hua E, Jiang S, Xie G (2012) Detection of the human prostate-specific antigen using an aptasensor with gold nanoparticles encapsulated by graphitized mesoporous carbon. Microchim Acta 178(1):163–170

    Article  CAS  Google Scholar 

  34. Shin KS, Ji JH, Hwang KS, Jun SC, Kang JY (2016) Sensitivity Enhancement of Bead-based Electrochemical Impedance Spectroscopy (BEIS) biosensor by electric field-focusing in microwells. Biosens Bioelectron 85:16–24

    Article  CAS  Google Scholar 

  35. Çevik E, Bahar Ö, Şenel M, Abasıyanık MF (2016) Construction of novel electrochemical immunosensor for detection of prostate specific antigen using ferrocene-PAMAM dendrimers. Biosens Bioelectron 86:1074–1079

    Article  CAS  Google Scholar 

  36. Novoselov KS, Geim AK, Morozov SV, Jiang D, Zhang Y, Dubonos SV, Grigorieva IV, Firsov AA (2004) Electric field effect in atomically thin carbon films. Science 306(5696):666–669

    Article  CAS  Google Scholar 

  37. Yan M, Zang D, Ge S, Ge L, Yu J (2012) A disposable electrochemical immunosensor based on carbon screen-printed electrodes for the detection of prostate specific antigen. Biosens Bioelectron 38(1):355–361

    Article  CAS  Google Scholar 

  38. Mao K, Wu D, Li Y, Ma H, Ni Z, Yu H, Luo C, Wei Q, Du B (2012) Label-free electrochemical immunosensor based on graphene/methylene blue nanocomposite. Anal Biochem 422(1):22–27

    Article  CAS  Google Scholar 

  39. Salimi A, Kavosi B, Fathi F, Hallaj R (2013) Highly sensitive immunosensing of prostate-specific antigen based on ionic liquid–carbon nanotubes modified electrode: Application as cancer biomarker for prostatebiopsies. Biosens Bioelectron 42:439–446

    Article  CAS  Google Scholar 

  40. Kavosi B, Salimi A, Hallaj R, Amani K (2014) A highly sensitive prostate-specific antigen immunosensor based on gold nanoparticles/PAMAM dendrimer loaded on MWCNTS/chitosan/ionic liquid nanocomposite. Biosens Bioelectron 52:20–28

    Article  CAS  Google Scholar 

  41. Feng J, Li Y, Li M, Li F, Han J, Dong Y, Chen Z, Wang P, Liu H, Wei Q (2017) A novel sandwich-type electrochemical immunosensor for PSA detection based on PtCu bimetallic hybrid (2D/2D) rGO/g-C3N4. Biosens Bioelectron 91:441–448

    Article  CAS  Google Scholar 

  42. Ding L-L, Ge J-P, Zhou W-Q, Gao J-P, Zhang Z-Y, Xiong Y (2016) Nanogold-functionalized g-C3N4 nanohybrids for sensitive impedimetric immunoassay of prostate-specific antigen using enzymatic biocatalytic precipitation. Biosens Bioelectron 85:212–219

    Article  CAS  Google Scholar 

  43. Liu L, Li Y, Tian L, Wei Q, Cao W (2016) Ultrasensitive sandwich-type prostate specific antigen immunosensor based on Ag overgrowth in Pd nano-octahedrons heterodimers decorated on amino functionalized multiwalled carbon nanotubes. Sensors Actuators B Chem 237:733–739

    Article  CAS  Google Scholar 

  44. Akter R, Rahman MA, Rhee CK (2012) Amplified Electrochemical Detection of a Cancer Biomarker by Enhanced Precipitation Using Horseradish Peroxidase Attached on Carbon Nanotubes. Anal Chem 84(15):6407–6415

    Article  CAS  Google Scholar 

  45. Li Y, Khan MS, Tian L, Liu L, Hu L, Fan D, Cao W, Wei Q (2017) An ultrasensitive electrochemical immunosensor for the detection of prostate-specific antigen based on conductivity nanocomposite with halloysite nanotubes. Anal Bioanal Chem: 1–7

  46. Wang H, Zhang Y, Yu H, Wu D, Ma H, Li H, Du B, Wei Q (2013) Label-free electrochemical immunosensor for prostate-specific antigen based on silver hybridized mesoporous silica nanoparticles. Anal Biochem 434(1):123–127

    Article  CAS  Google Scholar 

  47. Fan D, Li N, Ma H, Li Y, Hu L, Du B, Wei Q (2016) Electrochemical immunosensor for detection of prostate specific antigen based on an acid cleavable linker into MSN-based controlled release system. Biosens Bioelectron 85:580–586

    Article  CAS  Google Scholar 

  48. Jang HD, Kim SK, Chang H, Choi J-W (2015) 3D label-free prostate specific antigen (PSA) immunosensor based on graphene–gold composites. Biosens Bioelectron 63:546–551

    Article  CAS  Google Scholar 

  49. Han L, Liu C-M, Dong S-L, Du C-X, Zhang X-Y, Li L-H, Wei Y (2017) Enhanced conductivity of rGO/Ag NPs composites for electrochemical immunoassay of prostate-specific antigen. Biosens Bioelectron 87:466–472

    Article  CAS  Google Scholar 

  50. Hong W, Lee S, Jae Kim E, Lee M, Cho Y (2016) A reusable electrochemical immunosensor fabricated using a temperature-responsive polymer for cancer biomarker proteins. Biosens Bioelectron 78:181–186

    Article  CAS  Google Scholar 

  51. Pan L-H, Kuo S-H, Lin T-Y, Lin C-W, Fang P-Y, Yang H-W (2017) An electrochemical biosensor to simultaneously detect VEGF and PSA for early prostate cancer diagnosis based on graphene oxide/ssDNA/PLLA nanoparticles. Biosensors and Bioelectronics 89(Part 1):598–605

    Article  CAS  Google Scholar 

  52. Sharafeldin M, Bishop GW, Bhakta S, El-Sawy A, Suib SL, Rusling JF (2017) Fe3O4 nanoparticles on graphene oxide sheets for isolation and ultrasensitive amperometric detection of cancer biomarker proteins. Biosens Bioelectron 91:359–366

    Article  CAS  Google Scholar 

  53. Chuah K, Lai LMH, Goon IY, Parker SG, Amal R, Justin Gooding J (2012) Ultrasensitive electrochemical detection of prostate-specific antigen (PSA) using gold-coated magnetic nanoparticles as 'dispersible electrodes'. Chem Commun 48(29):3503–3505

    Article  CAS  Google Scholar 

  54. Ma H, Li Y, Wang Y, Hu L, Zhang Y, Fan D, Yan T, Wei Q (2016) Cubic Cu2O nanoframes with a unique edge-truncated structure and a good electrocatalytic activity for immunosensor application. Biosens Bioelectron 78:167–173

    Article  CAS  Google Scholar 

  55. Jiao L, Mu Z, Miao L, Du W, Wei Q, Li H (2017) Enhanced amperometric immunoassay for the prostate specific antigen using Pt-Cu hierarchical trigonal bipyramid nanoframes as a label. Microchim Acta 184(2):423–429

    Article  CAS  Google Scholar 

  56. Bhardwaj SK, Sharma AL, Bhardwaj N, Kukkar M, Gill AAS, Kim K-H, Deep A (2017) TCNQ-doped Cu-metal organic framework as a novel conductometric immunosensing platform for the quantification of prostate cancer antigen. Sens Actuat B: Chem 240:10–17

    Article  CAS  Google Scholar 

  57. Hong W, Lee S, Cho Y (2016) Dual-responsive immunosensor that combines colorimetric recognition and electrochemical response for ultrasensitive detection of cancer biomarkers. Biosens Bioelectron 86:920–926

    Article  CAS  Google Scholar 

  58. Li F, Li Y, Feng J, Dong Y, Wang P, Chen L, Chen Z, Liu H, Wei Q (2017) Ultrasensitive amperometric immunosensor for PSA detection based on Cu2O@CeO2-Au nanocomposites as integrated triple signal amplification strategy. Biosens Bioelectron 87:630–637

    Article  CAS  Google Scholar 

  59. Duangkaew P, Wutikhun T, Laocharoensuk R (2017) Triple signal amplification strategy based on size and shape transformation of ultrasmall sub-10 nm gold nanoparticles tag towards sensitivity improvement of electrochemical immunosensors. Sensors Actuators B Chem 239:430–437

    Article  CAS  Google Scholar 

  60. Kavosi B, Salimi A, Hallaj R, Moradi F (2015) Ultrasensitive electrochemical immunosensor for PSA biomarker detection in prostate cancer cells using gold nanoparticles/PAMAM dendrimer loaded with enzyme linked aptamer as integrated triple signal amplification strategy. Biosens Bioelectron 74:915–923

    Article  CAS  Google Scholar 

  61. Zhao L, Ma Z (2017) New immunoprobes based on bovine serum albumin-stabilized copper nanoclusters with triple signal amplification for ultrasensitive electrochemical immunosensing for tumor marker. Sensors Actuators B Chem 241:849–854

    Article  CAS  Google Scholar 

  62. Klukova L, Bertok T, Petrikova M, Sediva A, Mislovicova D, Katrlik J, Vikartovska A, Filip J, Kasak P, Andicsová-Eckstein A (2015) Glycoprofiling as a novel tool in serological assays of systemic sclerosis: A comparative study with three bioanalytical methods. Anal Chim Acta 853:555–562

    Article  CAS  Google Scholar 

  63. Tang Z, Wang L, Ma Z (2017) Triple sensitivity amplification for ultrasensitive electrochemical detection of prostate specific antigen. Biosens Bioelectron 92:577–582

    Article  CAS  Google Scholar 

  64. Zhu Y, Wang H, Wang L, Zhu J, Jiang W (2016) Cascade Signal Amplification Based on Copper Nanoparticle-Reported Rolling Circle Amplification for Ultrasensitive Electrochemical Detection of the Prostate Cancer Biomarker. ACS Appl Mater Interfaces 8(4):2573–2581

    Article  CAS  Google Scholar 

  65. Strzemińska I, Sainte Rose Fanchine S, Anquetin G, Reisberg S, Noël V, Pham MC, Piro B (2016) Grafting of a peptide probe for Prostate-Specific Antigen detection using diazonium electroreduction and click chemistry. Biosens Bioelectron 81:131–137

    Article  CAS  Google Scholar 

  66. Parnsubsakul A, Safitri RE, Rijiravanich P, Surareungchai W (2017) Electrochemical assay of proteolytically active prostate specific antigen based on anodic stripping voltammetry of silver enhanced gold nanoparticle labels. J Electroanal Chem 785:125–130

    Article  CAS  Google Scholar 

  67. Heydari-Bafrooei E, Shamszadeh NS (2017) Electrochemical bioassay development for ultrasensitive aptasensing of prostate specific antigen. Biosens Bioelectron 91:284–292

    Article  CAS  Google Scholar 

  68. Tahmasebi F, Noorbakhsh A (2016) Sensitive Electrochemical Prostate Specific Antigen Aptasensor: Effect of Carboxylic Acid Functionalized Carbon Nanotube and Glutaraldehyde Linker. Electroanalysis 28(5):1134–1145

    Article  CAS  Google Scholar 

  69. Rahi A, Sattarahmady N, Heli H (2016) Label-free electrochemical aptasensing of the human prostate-specific antigen using gold nanospears. Talanta 156–157:218–224

    Article  CAS  Google Scholar 

  70. Jolly P, Formisano N, Tkáč J, Kasák P, Frost CG, Estrela P (2015) Label-free impedimetric aptasensor with antifouling surface chemistry: A prostate specific antigen case study. Sensors Actuators B Chem 209:306–312

    Article  CAS  Google Scholar 

  71. Tzouvadaki I, Jolly P, Lu X, Ingebrandt S, de Micheli G, Estrela P, Carrara S (2016) Label-Free Ultrasensitive Memristive Aptasensor. Nano Lett 16(7):4472–4476

    Article  CAS  Google Scholar 

  72. Deng H, Li J, Zhang Y, Pan H, Xu G (2016) A new strategy for label-free electrochemical immunoassay based on “gate-effect” of β-cyclodextrin modified electrode. Anal Chim Acta 926:48–54

    Article  CAS  Google Scholar 

  73. Xie S, Zhang J, Yuan Y, Chai Y, Yuan R (2015) An electrochemical peptide cleavage-based biosensor for prostate specific antigen detection via host-guest interaction between ferrocene and [small beta]-cyclodextrin. Chem Commun 51(16):3387–3390

    Article  CAS  Google Scholar 

  74. Gao C, Zhang L, Wang Y, Yu J, Song X (2016) Visible-light driven biofuel cell based on hierarchically branched titanium dioxide nanorods photoanode for tumor marker detection. Biosens Bioelectron 83:327–333

    Article  CAS  Google Scholar 

  75. Pihíková D, Belicky Š, Kasák P, Bertok T, Tkac J (2016) Sensitive detection and glycoprofiling of a prostate specific antigen using impedimetric assays. Analyst 141(3):1044–1051

    Article  CAS  Google Scholar 

  76. Pihikova D, Pakanova Z, Nemcovic M, Barath P, Belicky S, Bertok T, Kasak P, Mucha J, Tkac J (2016) Sweet characterisation of prostate specific antigen using electrochemical lectin-based immunosensor assay and MALDI TOF/TOF analysis: Focus on sialic acid. Proteomics 16(24):3085–3095

    Article  CAS  Google Scholar 

  77. Pihikova D, Kasak P, Kubanikova P, Sokol R, Tkac J (2016) Aberrant sialylation of a prostate-specific antigen: Electrochemical label-free glycoprofiling in prostate cancer serum samples. Anal Chim Acta 934:72–79

    Article  CAS  Google Scholar 

  78. Xia N, Deng D, Zhang L, Yuan B, Jing M, Du J, Liu L (2013) Sandwich-type electrochemical biosensor for glycoproteins detection based on dual-amplification of boronic acid-gold nanoparticles and dopamine-gold nanoparticles. Biosens Bioelectron 43:155–159

    Article  CAS  Google Scholar 

  79. Cao Y, Yuan R, Chai Y, Mao L, Niu H, Liu H, Zhuo Y (2012) Ultrasensitive luminol electrochemiluminescence for protein detection based on in situ generated hydrogen peroxide as coreactant with glucose oxidase anchored AuNPs@MWCNTs labeling. Biosens Bioelectron 31(1):305–309

    Article  CAS  Google Scholar 

  80. Xu Y, Liu J, Gao C, Wang E (2014) Applications of carbon quantum dots in electrochemiluminescence: A mini review. Electrochem Commun 48:151–154

    Article  CAS  Google Scholar 

  81. Jiao T, Leca-Bouvier BD, Boullanger P, Blum LJ, Girard-Egrot AP (2008) Electrochemiluminescent detection of hydrogen peroxide using amphiphilic luminol derivatives in solution. Colloids Surf A Physicochem Eng Asp 321 (1–3):143-146

  82. Liu D-Y, Xin Y-Y, He X-W, Yin X-B (2011) A sensitive, non-damaging electrochemiluminescent aptasensor via a low potential approach at DNA-modified gold electrodes. Analyst 136(3):479–485

    Article  CAS  Google Scholar 

  83. Parveen S, Aslam MS, Hu L, Xu G (2013) Electrogenerated Chemiluminescence: Protocols and Applications. Springer

  84. Zhang F, Mao L, Zhu M (2014) Ultrasensitive immunoassay for free prostate-specific antigen based on ferrocenecarboxylate enhanced cathodic electrochemiluminescence of peroxydisulfate. Microchim Acta 181(11):1285–1291

    Article  CAS  Google Scholar 

  85. Xu X (2016) Sensitive Electrochemiluminescence Immunosensor for Determination of Tumor Biomarker PSA Based on Multifunctionalized Pt/Ag@BSA Core–Shell Nanoparticles. Bull Kor Chem Soc 37(4):452–457

    Article  CAS  Google Scholar 

  86. Ge S, Yu J, Jiao X, Chen D (2013) Ultrasensitive Electrochemiluminescence Immunoassay for Protein Specific Detection Based on Dendrimer-Encapsulated Gold Nanoparticles Labels. J Inorg Organomet Polym Mater 23(5):1113–1121

    Article  CAS  Google Scholar 

  87. Sardesai NP, Kadimisetty K, Faria R, Rusling JF (2013) A microfluidic electrochemiluminescent device for detecting cancer biomarker proteins. Anal Bioanal Chem 405(11):3831–3838

    Article  CAS  Google Scholar 

  88. Kadimisetty K, Malla S, Sardesai NP, Joshi AA, Faria RC, Lee NH, Rusling JF (2015) Automated multiplexed ECL Immunoarrays for cancer biomarker proteins. Anal Chem 87(8):4472–4478

    Article  CAS  Google Scholar 

  89. Deng W, Chu C, Ge S, Yu J, Yan M, Song X (2015) Electrochemiluminescence PSA assay using an ITO electrode modified with gold and palladium, and flower-like titanium dioxide microparticles as ECL labels. Microchim Acta 182(5):1009–1016

    Article  CAS  Google Scholar 

  90. Li W, Dai W, Ge L, Ge S, Yan M, Yu J (2013) Electropolymerized Poly(3,4-ethylendioxythiophene)/Graphene Composite Film and its Application in Quantum Dots Electrochemiluminescence Immunoassay. J Inorg Organomet Polym Mater 23(3):719–725

    Article  CAS  Google Scholar 

  91. Ma H, Li X, Yan T, Li Y, Zhang Y, Wu D, Wei Q, Du B (2016) Electrochemiluminescent immunosensing of prostate-specific antigen based on silver nanoparticles-doped Pb (II) metal-organic framework. Biosens Bioelectron 79:379–385

    Article  CAS  Google Scholar 

  92. Wu D, Liu Y, Wang Y, Hu L, Ma H, Wang G, Wei Q (2016) Label-free Electrochemiluminescent Immunosensor for Detection of Prostate Specific Antigen based on Aminated Graphene Quantum Dots and Carboxyl Graphene Quantum Dots. Sci Rep 6:20511

    Article  CAS  Google Scholar 

  93. Zhao Y, Wang Q, Li J, Ma H, Zhang Y, Wu D, Du B, Wei Q (2016) A CeO2-matrical enhancing ECL sensing platform based on the Bi2S3-labeled inverted quenching mechanism for PSA detection. J Mater Chem B 4(17):2963–2971

    Article  CAS  Google Scholar 

  94. Tian CY, Zhao WW, Wang J, Xu JJ, Chen HY (2012) Amplified quenching of electrochemiluminescence from CdS sensitized TiO2 nanotubes by CdTe-carbon nanotube composite for detection of prostate protein antigen in serum. Analyst 137(13):3070–3075

    Article  CAS  Google Scholar 

  95. Ma H, Zhou J, Li Y, Han T, Zhang Y, Hu L, Du B, Wei Q (2016) A label-free electrochemiluminescence immunosensor based on EuPO4 nanowire for the ultrasensitive detection of Prostate specific antigen. Biosens Bioelectron 80:352–358

    Article  CAS  Google Scholar 

  96. Yang J-J, Cao J-T, Wang H, Liu Y-M, Ren S-W (2017) Ferrocene-graphene sheets for high-efficiency quenching of electrochemiluminescence from Au nanoparticles functionalized cadmium sulfide flower-like three dimensional assemblies and sensitive detection of prostate specific antigen. Talanta 167:325–332

    Article  CAS  Google Scholar 

  97. He Y, Chai Y, Yuan R, Wang H, Bai L, Liao N (2014) A supersandwich electrochemiluminescence immunosensor based on mimic-intramolecular interaction for sensitive detection of proteins. Analyst 139(20):5209–5214

    Article  CAS  Google Scholar 

  98. Damborský P, Švitel J, Katrlík J (2016) Optical biosensors. Essays Biochem 60(1):91–100

    Article  Google Scholar 

  99. Vigneshvar S, Sudhakumari CC, Senthilkumaran B, Prakash H (2016) Recent Advances in Biosensor Technology for Potential Applications – An Overview. Front Bioeng Biotechnol 4:11

    Article  CAS  Google Scholar 

  100. Esseghaier C, Suaifan GARY, Ng A, Zourob M (2014) One-Step Assay for Optical Prostate Specific Antigen Detection Using Magnetically Engineered Responsive Thin Film. J Biomed Nanotechnol 10(6):1123–1129

    Article  CAS  Google Scholar 

  101. Berthuy OI, Blum LJ, Marquette CA (2015) Cancer-cells on a chip for label-free optic detection of secreted molecules. In: Baldini F, Homola J, Lieberman RA (eds) Optical Sensors 2015, vol 9506. Proceedings of SPIE. pp 950615–950615-950618. doi:10.1117/12.2179883

  102. Damborský P, Madaboosi N, Chu V, Conde JP, Katrlík J (2015) Surface plasmon resonance application in prostate cancer biomarker research. Chem Pap 69(1):143–149

    Article  CAS  Google Scholar 

  103. Soelberg SD, Stevens RC, Limaye AP, Furlong CE (2009) Surface Plasmon Resonance Detection Using Antibody-Linked Magnetic Nanoparticles for Analyte Capture, Purification, Concentration, and Signal Amplification. Anal Chem 81(6):2357–2363

    Article  CAS  Google Scholar 

  104. Lyon LA, Musick MD, Natan MJ (1998) Colloidal Au-Enhanced Surface Plasmon Resonance Immunosensing. Anal Chem 70(24):5177–5183

    Article  CAS  Google Scholar 

  105. Uludag Y, Tothill IE (2012) Cancer Biomarker Detection in Serum Samples Using Surface Plasmon Resonance and Quartz Crystal Microbalance Sensors with Nanoparticle Signal Amplification. Anal Chem 84(14):5898–5904

    Article  CAS  Google Scholar 

  106. Ertürk G, Özen H, Tümer MA, Mattiasson B, Denizli A (2016) Microcontact imprinting based surface plasmon resonance (SPR) biosensor for real-time and ultrasensitive detection of prostate specific antigen (PSA) from clinical samples. Sens Actuat B: Chem 224:823–832

    Article  CAS  Google Scholar 

  107. Stephenson-Brown A, Acton AL, Preece JA, Fossey JS, Mendes PM (2015) Selective glycoprotein detection through covalent templating and allosteric click-imprinting. Chem Sci 6(9):5114–5119

    Article  CAS  Google Scholar 

  108. Hong Y, Huh Y-M, Yoon DS, Yang J (2012) Nanobiosensors Based on Localized Surface Plasmon Resonance for Biomarker Detection. J Nanomater 2012:13

    Google Scholar 

  109. Aćimović SS, Ortega MA, Sanz V, Berthelot J, Garcia-Cordero JL, Renger J, Maerkl SJ, Kreuzer MP, Quidant R (2014) LSPR Chip for Parallel, Rapid, and Sensitive Detection of Cancer Markers in Serum. Nano Lett 14(5):2636–2641

    Article  CAS  Google Scholar 

  110. Hwang WS, Truong PL, Sim SJ (2012) Size-dependent plasmonic responses of single gold nanoparticles for analysis of biorecognition. Anal Biochem 421(1):213–218

    Article  CAS  Google Scholar 

  111. Xuan Z, Li M, Rong P, Wang W, Li Y, Liu D (2016) Plasmonic ELISA based on the controlled growth of silver nanoparticles. Nano 8(39):17271–17277

    CAS  Google Scholar 

  112. De La Rica R, Stevens MM (2012) Plasmonic ELISA for the ultrasensitive detection of disease biomarkers with the naked eye. Nat Nanotechnol 7(12):821–824

    Article  CAS  Google Scholar 

  113. De La Rica R, Stevens MM (2013) Plasmonic ELISA for the detection of analytes at ultralow concentrations with the naked eye. Nat Protoc 8(9):1759–1764

    Article  CAS  Google Scholar 

  114. Howes PD, Rana S, Stevens MM (2014) Plasmonic nanomaterials for biodiagnostics. Chem Soc Rev 43(11):3835–3853

    Article  CAS  Google Scholar 

  115. Liang J, Yao C, Li X, Wu Z, Huang C, Fu Q, Lan C, Cao D, Tang Y (2015) Silver nanoprism etching-based plasmonic ELISA for the high sensitive detection of prostate-specific antigen. Biosens Bioelectron 69:128–134

    Article  CAS  Google Scholar 

  116. Xia Y, Ye J, Tan K, Wang J, Yang G (2013) Colorimetric Visualization of Glucose at the Submicromole Level in Serum by a Homogenous Silver Nanoprism–Glucose Oxidase System. Anal Chem 85(13):6241–6247

    Article  CAS  Google Scholar 

  117. Liu D, Yang J, Wang H-F, Wang Z, Huang X, Wang Z, Niu G, Hight Walker AR, Chen X (2014) Glucose Oxidase-Catalyzed Growth of Gold Nanoparticles Enables Quantitative Detection of Attomolar Cancer Biomarkers. Anal Chem 86(12):5800–5806

    Article  CAS  Google Scholar 

  118. Mullett WM, Lai EP, Yeung JM (2000) Surface plasmon resonance-based immunoassays. Methods 22(1):77–91

    Article  CAS  Google Scholar 

  119. Sanders M, Lin Y, Wei J, Bono T, Lindquist RG (2014) An enhanced LSPR fiber-optic nanoprobe for ultrasensitive detection of protein biomarkers. Biosens Bioelectron 61:95–101

    Article  CAS  Google Scholar 

  120. Uh M, Kim JS, Park JH, Jeong DH, Lee HY, Lee SM, Lee SK (2017) Fabrication of localized surface plasmon resonance sensor based on optical fiber and micro fluidic channel. J Nanosci Nanotechnol 17(2):1083–1091

    Article  CAS  Google Scholar 

  121. Uh M, Kang S-K, Park J-H, Jeong DH, Lee H-Y, Lee S-M, Lee S-K (2016) Analysis and Optimization of Antibody Immobilization for Immunoassay Using Fiber-Optic Localized Surface Plasmon Resonance Biosensors. Nanosci Nanotechnol Lett 8(1):8–12

    Article  Google Scholar 

  122. Jeong HH, Erdene N, Park JH, Jeong DH, Lee HY, Lee SK (2013) Real-time label-free immunoassay of interferon-gamma and prostate-specific antigen using a Fiber-Optic Localized Surface Plasmon Resonance sensor. Biosens Bioelectron 39(1):346–351

    Article  CAS  Google Scholar 

  123. Breault-Turcot J, Poirier-Richard HP, Couture M, Pelechacz D, Masson JF (2015) Single chip SPR and fluorescent ELISA assay of prostate specific antigen. Lab Chip 15(23):4433–4440

    Article  CAS  Google Scholar 

  124. Xu DD, Deng YL, Li CY, Lin Y, Tang HW (2017) Metal-enhanced fluorescent dye-doped silica nanoparticles and magnetic separation: A sensitive platform for one-step fluorescence detection of prostate specific antigen. Biosens Bioelectron 87:881–887

    Article  CAS  Google Scholar 

  125. Zhang Q, Wu L, Wong TI, Zhang J, Liu X, Zhou X, Bai P, Liedberg B, Wang Y (2017) Surface plasmon-enhanced fluorescence on Au nanohole array for prostate-specific antigen detection. Int J Nanomedicine 12:2307–2314

    Article  Google Scholar 

  126. Wang J, Mountziaris TJ (2013) Homogeneous immunoassays based on fluorescence emission intensity variations of zinc selenide quantum dot sensors. Biosens Bioelectron 41:143–149

    Article  CAS  Google Scholar 

  127. Pei H, Zhu S, Yang M, Kong R, Zheng Y, Qu F (2015) Graphene oxide quantum dots@silver core–shell nanocrystals as turn-on fluorescent nanoprobe for ultrasensitive detection of prostate specific antigen. Biosens Bioelectron 74:909–914

    Article  CAS  Google Scholar 

  128. Ming T, Zhao L, Yang Z, Chen H, Sun L, Wang J, Yan C (2009) Strong polarization dependence of plasmon-enhanced fluorescence on single gold nanorods. Nano Lett 9(11):3896–3903

    Article  CAS  Google Scholar 

  129. Ma H, Li B, Zhang L, Han D, Zhu G (2015) Targeted synthesis of core-shell porous aromatic frameworks for selective detection of nitro aromatic explosives via fluorescence two-dimensional response. J Mater Chem A 3(38):19346–19352

    Article  CAS  Google Scholar 

  130. Song HY, Wong TI, Sadovoy A, Wu L, Bai P, Deng J, Guo S, Wang Y, Knoll W, Zhou X (2015) Imprinted gold 2D nanoarray for highly sensitive and convenient PSA detection via plasmon excited quantum dots. Lab Chip 15(1):253–263

    Article  CAS  Google Scholar 

  131. Frascione N, Gooch J, Abbate V, Daniel B (2015) Fluorogenic displacement biosensors for PSA detection using antibody-functionalised quantum dot nanoparticles. RSC Adv 5(9):6595–6598

    Article  CAS  Google Scholar 

  132. Liu D, Huang X, Wang Z, Jin A, Sun X, Zhu L, Wang F, Ma Y, Niu G, HightWalker AR, Chen X (2013) Gold Nanoparticle Based Activatable Probe for Sensing Ultra-Low Levels of Prostate Specific Antigen. ACS Nano 7(6):5568–5576

    Article  CAS  Google Scholar 

  133. Lee S, Hosokawa K, Kim S, Jeong OC, Lilja H, Laurell T, Maeda M (2016) Porous silicon microarray for simultaneous fluorometric immunoassay of the biomarkers prostate-specific antigen and human glandular kallikrein 2. Microchim Acta 183(12):3321–3327

    Article  CAS  Google Scholar 

  134. Kong R-M, Ding L, Wang Z, You J, Qu F (2015) A novel aptamer-functionalized MoS2 nanosheet fluorescent biosensor for sensitive detection of prostate specific antigen. Anal Bioanal Chem 407(2):369–377

    Article  CAS  Google Scholar 

  135. Barbosa AI, Gehlot P, Sidapra K, Edwards AD, Reis NM (2015) Portable smartphone quantitation of prostate specific antigen (PSA) in a fluoropolymer microfluidic device. Biosens Bioelectron 70:5–14

    Article  CAS  Google Scholar 

  136. Tsunoda M, Imai K (2005) Analytical applications of peroxyoxalate chemiluminescence. Anal Chim Acta 541(1–2):13–23

    Article  CAS  Google Scholar 

  137. Liu R, Wang C, Jiang Q, Zhang W, Yue Z, Liu G (2013) Magnetic-particle-based, ultrasensitive chemiluminescence enzyme immunoassay for free prostate-specific antigen. Anal Chim Acta 801:91–96

    Article  CAS  Google Scholar 

  138. Xie X, Ohnishi N, Takahashi Y, Kondo A (2009) Application of magnetic nanoparticles in full-automated chemiluminescent enzyme immunoassay. J Magn Magn Mater 321(10):1686–1688

    Article  CAS  Google Scholar 

  139. Cha T, Cho S, Kim YT, Lee JH (2014) Rapid aptasensor capable of simply diagnosing prostate cancer. Biosens Bioelectron 62:31–37

    Article  CAS  Google Scholar 

  140. Porter MD, Lipert RJ, Siperko LM, Wang G, Narayanan R (2008) SERS as a bioassay platform: fundamentals, design, and applications. Chem Soc Rev 37(5):1001–1011

    Article  CAS  Google Scholar 

  141. Gao R, Cheng Z, deMello AJ, Choo J (2016) Wash-free magnetic immunoassay of the PSA cancer marker using SERS and droplet microfluidics. Lab Chip 16(6):1022–1029

    Article  CAS  Google Scholar 

  142. Yang A-q, Wang D, Wang X, Han Y, X-b K, Wang H-j, Zhou X, Ren L (2015) Rational design of Au nanorods assemblies for highly sensitive and selective SERS detection of prostate specific antigen. RSC Adv 5(48):38354–38360

    Article  CAS  Google Scholar 

  143. Koukouvinos G, Petrou PS, Misiakos K, Drygiannakis D, Raptis I, Goustouridis D, Kakabakos SE (2015) A label-free flow-through immunosensor for determination of total- and free-PSA in human serum samples based on white-light reflectance spectroscopy. Sens Actuat B: Chem 209:1041–1048

    Article  CAS  Google Scholar 

  144. Alzghoul S, Hailat M, Zivanovic S, Que L, Shah GV (2016) Measurement of serum prostate cancer markers using a nanopore thin film based optofluidic chip. Biosens Bioelectron 77:491–498

    Article  CAS  Google Scholar 

  145. Kumar A (2000) Biosensors based on piezoelectric crystal detectors: theory and application. JOM-e 52(10):1–6

    Google Scholar 

  146. Jokerst JV, Chen Z, Xu L, Nolley R, Chang E, Mitchell B, Brooks JD, Gambhir SS (2015) A Magnetic Bead-Based Sensor for the Quantification of Multiple Prostate Cancer Biomarkers. PLoS One 10(9):e0139484

    Article  CAS  Google Scholar 

  147. Kosaka PM, PiniV, Ruz JJ, da Silva RA, González MU, RamosD, CallejaM, TamayoJ (2014) Detection of cancer biomarkers in serum using a hybrid mechanical and optoplasmonic nanosensor. Nat Nano 9 (12):1047-1053

  148. Arlett JL, Myers EB, Roukes ML (2011) Comparative advantages of mechanical biosensors. Nat Nano 6(4):203–215

    Article  CAS  Google Scholar 

  149. Lee H-J, Lee J-H, Moon H-S, Jang I-S, Choi J-S, Yook J-G, Jung H-I (2012) A planar split-ring resonator-based microwave biosensor for label-free detection of biomolecules. Sens Actuat B: Chem 169:26–31

    Article  CAS  Google Scholar 

  150. Moser HO, Casse BDF, Wilhelmi O, Saw BT (2005) Terahertz Response of a Microfabricated Rod\char21{}Split-Ring-Resonator Electromagnetic Metamaterial. Phys Rev Lett 94(6):063901

    Article  CAS  Google Scholar 

  151. Zhang F, Li S, Cao K, Wang P, Su Y, Zhu X, Wan Y (2015) A Microfluidic Love-Wave Biosensing Device for PSA Detection Based on an Aptamer Beacon Probe. Sensors 15(6)

  152. Lange K, Rapp BE, Rapp M (2008) Surface acoustic wave biosensors: a review. Anal Bioanal Chem 391(5):1509–1519

    Article  CAS  Google Scholar 

  153. Sun X, Lei C, Guo L, Zhou Y (2016) Sandwich immunoassay for the prostate specific antigen using a micro-fluxgate and magnetic bead labels. Microchim Acta 183(8):2385–2393

    Article  CAS  Google Scholar 

  154. Lei J, Wang T, Lei C, Zhou Y (2013) Detection of Dynabeads using a micro-electro-mechanical-systems fluxgate sensor. Appl Phys Lett 102(2):022413

    Article  CAS  Google Scholar 

  155. Sun X, Zhi S, Lei C, Zhou Y (2016) Investigation of contactless detection using a giant magnetoresistance sensor for detecting prostate specific antigen. Biomed Microdevices 18(4):60

    Article  CAS  Google Scholar 

  156. Jiang X, Cheng S, Chen W, Wang L, Shi F, Zhu C (2012) Comparison of oligonucleotide-labeled antibody probe assays for prostate-specific antigen detection. Anal Biochem 424(1):1–7

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The financial support received from the Slovak Scientific Grant Agency VEGA 2/0162/14 and the Slovak Research and Development Agency APVV-14-0753 is acknowledged. The research leading to these results received funding from the European Research Council under the European Union’s Seventh Framework Program (FP/2007-2013)/ERC grant agreement number 311532. This publication was made possible by NPRP grant number 6-381-1-078 from the Qatar National Research Fund (a member of the Qatar Foundation). The statements made herein are solely the responsibility of the authors. This publication is the result of the project implementation: Centre for materials, layers and systems for applications and chemical processes under extreme conditions – Stage I, ITMS No.: 26240120007, supported by the Research & Development Operational Program funded by the ERDF.

Author information

Authors and Affiliations

  1. Department of Glycobiotechnology, Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, SK-845 38, Bratislava, Slovakia

    Dominika Damborska, Tomas Bertok, Erika Dosekova, Alena Holazova, Lenka Lorencova & Jan Tkac

  2. Center for Advanced Materials, Qatar University, P.O. Box 2713, Doha, Qatar

    Peter Kasak

Authors
  1. Dominika Damborska
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tomas Bertok
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Erika Dosekova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alena Holazova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lenka Lorencova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Peter Kasak
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jan Tkac
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jan Tkac.

Ethics declarations

The author(s) declare that they have no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Damborska, D., Bertok, T., Dosekova, E. et al. Nanomaterial-based biosensors for detection of prostate specific antigen. Microchim Acta 184, 3049–3067 (2017). https://doi.org/10.1007/s00604-017-2410-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00604-017-2410-1

Keywords

Search

Navigation