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Porous covalent organonitridic frameworks for solid-phase extraction of sulfonamide antibiotics

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Abstract

Porous covalent organonitridic frameworks (PCONFs) were applied as a packing in a solid-phase extraction cartridge for rapid extraction of eight sulfonamide antibiotics from complex samples. The detection was performed by liquid chromatography–tandem mass spectrometry under the multiple reaction monitoring mode. This enabled ultrasensitive, dependable and cost-effective simultaneous analysis of sulfacetamide, sulfadiazine, sulfathiazole, sulfapyridine, sulfamerazine, sulfamethazine, sulfamethoxazole and sulfisoxazole. Main parameters affecting the performance of the PCONF-packed cartridge were investigated. Under optimized conditions, this method has attractive features such as wide linear ranges (2.5–1000 ng·L−1), low limits of detection (0.14–2.0 ng·L−1), and good repeatability (intra-day assay: 2.1%–5.6%; inter-day assay: 2.3%–12.9%). It was successfully applied in the analysis of sulfonamide residues in water, milk and chicken meat samples.

The use of a porous covalent organonitridic framework (PCONFs) as solid-phase extraction (SPE) material is described here for the first time. An ultrasensitive, dependable and cost-effective method was developed for simultaneous analysis of eight sulfonamide residues in water, milk and chicken meat samples by coupling PCONF-based SPE with liquid chromatography–tandem mass spectrometry.

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Acknowledgements

This work was supported by National Natural Science Foundation of China (21777089 and 21477068), Key Research and Development Program of Shandong Province (2017GSF17107 and 2018GSF117036), Natural Science Foundation of Shandong Province (ZR2018LB033 and ZR2017LB026), Youth Science Funds of Shandong Academy of Sciences (2018QN002), and Shandong Province Taishan Scholar Program (ts201712063).

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Authors and Affiliations

  1. Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Analysis and Test Centre, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250014, China

    Guiju Xu, Beibei Zhang, Xiaoli Wang, Na Li, Yanfang Zhao, Lu Liu & Ru-Song Zhao

  2. Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing, 100084, China

    Jin-Ming Lin

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  1. Guiju Xu
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  2. Beibei Zhang
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  3. Xiaoli Wang
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  4. Na Li
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Correspondence to Ru-Song Zhao.

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Xu, G., Zhang, B., Wang, X. et al. Porous covalent organonitridic frameworks for solid-phase extraction of sulfonamide antibiotics. Microchim Acta 186, 26 (2019). https://doi.org/10.1007/s00604-018-3152-4

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