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Dengue virus: a review on advances in detection and trends – from conventional methods to novel biosensors

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Abstract

Dengue virus is an important arbovirus infection which transmitted by the Aedes female mosquitoes. The attempt to control and early detection of this infection is a global public health issue at present. Because of the clinical importance of its detection, the main focus of this review is on all of the methods that can offer the new diagnosis strategies. The advantages and disadvantages of reported methods have been discussed comprehensively from different aspects like biomarkers type, sensitivity, accuracy, rate of detection, possibility of commercialization, availability, limit of detection, linear range, simplicity, mechanism of detection, and ability of usage for clinical applications. The optical, electrochemical, microfluidic, enzyme linked immunosorbent assay (ELISA), and smartphone-based biosensors are the main approaches which developed for detection of different biomarkers and serotypes of Dengue virus. Future efforts in miniaturization of these methods open the horizons for development of commercial biosensors for early-diagnosis of Dengue virus infection.

Transmission of Dengue virus by the biting of an Aedes aegypti mosquito, the symptoms of Dengue hemorrhagic fever and the structure of Dengue virus and application of biosensors for its detection.

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Acknowledgments

The Authors are grateful for financial support from the Immunology Research Center, Tabriz University of Medical Sciences.

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Authors and Affiliations

  1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran

    Reza Eivazzadeh-Keihan, Karim Khanmohammadi Chenab, Fateme Radinekiyan & Ali Maleki

  2. Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran

    Paria Pashazadeh-Panahi

  3. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Paria Pashazadeh-Panahi, Tohid Mahmoudi, Behzad Baradaran & Ahad Mokhtarzadeh

  4. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran

    Mahmoud Hashemzaei

  5. Department of Biotechnology, Higher Education Institute of Rab-Rashid, Tabriz, Iran

    Ahad Mokhtarzadeh

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  1. Reza Eivazzadeh-Keihan
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Eivazzadeh-Keihan, R., Pashazadeh-Panahi, P., Mahmoudi, T. et al. Dengue virus: a review on advances in detection and trends – from conventional methods to novel biosensors. Microchim Acta 186, 329 (2019). https://doi.org/10.1007/s00604-019-3420-y

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