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Integrating brucine with carbon nanotubes toward electrochemical sensing of hydroxylamine

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Abstract

Based on the intrinsic electrochemical features of brucine integrated with carbon nanotubes (brucine/SWNTs), dimeric quinoid brucine was electrochemically generated by electroactivation of a brucine/SWNTs-modified GC electrode and used as a novel electrocatalyst for efficient electro-oxidation of hydroxylamine (HA). The electrocatalytic activity was investigated with cyclic voltammetry in the range pH 2.0 to pH 11.0, and the best electrocatalytic performance of the electrocatalyst was obtained at pH 10.0. By taking advantage of the electrocatalytic activity of the dimeric quinoid brucine toward HA, we have developed an electrochemical sensor for HA measurements based on a brucine/SWNTS-modified GC electrode using amperometry with the applied potential of + 0.1 V (vs. Ag/AgCl). Under the optimized conditions, the current response toward HA concentration shows a linear relationship in the dynamic ranges of 0.1–10 μM and 10–1000 μM with a detection limit of 0.021 μM based on the 3σ criterion. The sensor was used to assay HA in pharmaceuticals including hydroxyurea tablets and pralidoxime iodide injections with satisfactory results. The spike-and-recovery for samples of tap water (n = 9) and lake water (n = 9) was within 97.17–100.16%.

Schematic illustration of electrochemical sensing of hydroxylamine (HA) enabled by integrating brucine with single-walled carbon nanotube (brucine/SWNTs) based on electro-activation of brucine/SWNTs-modified GC electrode

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Funding

This work was financially supported by the National Natural Science Foundation of China (Grant No. 21505002), 2017 Anhui Province Foundation for the Returned Scholars (No. 19), Excellent Young Talents Fund Program of Higher Education Institutions of Anhui Province (Grant No. gxyq2018026), and Provincial Natural Science Foundation of Anhui (Grant No.1708085QH188).

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  1. Weiyan Xi and Jiali Zhai contributed equally to this work.

Authors and Affiliations

  1. School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China

    Weiyan Xi, Jiali Zhai, Yunjing Zhang, Lei Tian & Zipin Zhang

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  1. Weiyan Xi
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  2. Jiali Zhai
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Correspondence to Zipin Zhang.

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Xi, W., Zhai, J., Zhang, Y. et al. Integrating brucine with carbon nanotubes toward electrochemical sensing of hydroxylamine. Microchim Acta 187, 343 (2020). https://doi.org/10.1007/s00604-020-04315-6

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