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A 433-MHz surface acoustic wave sensor with Ni-TiO2-poly(L-lysine) composite film for dopamine determination

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Abstract

A ternary hybrid material composed of Ni nanoparticles (NPs), TiO2 NPs, and poly(L-lysine) (Ply) was used as a sensing material. It was electrodeposited in situ onto a commercial 433-MHz surface acoustic wave (SAW) resonator to construct a Ni-TiO2-Ply/SAW sensor. The Ni-TiO2-Ply sensing layer fully covered the resonant cavity of the SAW resonator. As the sensing layer completely covers the interdigital transducer and piezoelectric substrate, the sensing area is significantly increased, and the resonator is protected from damage or contamination. To detect the level of dopamine (DA) in serum, the fabrication of the Ni-TiO2-Ply sensing layer, distributions of various components in the sensing layer, and responses of the SAW biosensor to DA were investigated in detail. In addition, an electric field-assisted liquid-phase oxidation technique was developed for loading analytes onto the SAW sensors. After optimizing the pH value and L-lysine content of the sensing layer electrolyte and the pH value of the DA solution, the SAW biosensor responded to DA with a linear concentration range of 1 to 1000 nM, sensitivity of 5.77 MHz nM−1 cm−2, and limit of detection of 0.067 nM. Moreover, the sensor exhibited good selectivity, reproducibility, and stability at ambient temperature.

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Funding

This study was financially supported by the National Key Research and Development Program of China (No. 2016YFB0402700) and the Natural Science Foundation of Tianjin City (Nos. 17JCZDJC32600 and 17JCQNJC00900).

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Authors and Affiliations

  1. Tianjin Key Laboratory of Film Electronic and Communication Devices, Engineering Research Center of Optoelectronic Devices & Communication Technology (Ministry of Education), School of Electrical and Electronic Engineering, Tianjin University of Technology, Tianjin, 300384, People’s Republic of China

    Jingyi Han, Mingji Li, Huayi Li, Cuiping Li, Lirong Qian & Baohe Yang

  2. Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin Key Laboratory of Drug Targeting and Bioimaging, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin, 300384, People’s Republic of China

    Hongji Li

  3. National Center for Nanoscience and Technology (NCNST), Beijing, 100190, People’s Republic of China

    Honglang Li

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  1. Jingyi Han
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  3. Hongji Li
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Correspondence to Mingji Li, Hongji Li or Honglang Li.

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The online version of this article contains supplementary material, which is available to authorized users: CV curves; AFM images; and Frequency characteristic curves.

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Han, J., Li, M., Li, H. et al. A 433-MHz surface acoustic wave sensor with Ni-TiO2-poly(L-lysine) composite film for dopamine determination. Microchim Acta 187, 671 (2020). https://doi.org/10.1007/s00604-020-04635-7

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