Abstract.
Fluoxetine hydrochloride reacts with benzoyl peroxide and potassium iodide, after heating for 1 min at 30 °C, to give a blue colour having maximum absorbance at 570 nm. The reaction is selective for fluoxetine with 0.01 mg/mL as visual limit of quantitation and provides a basis for a new spectrophotometric determination. The colour reaction obeys Beer’s law from 0.1 mg/10 mL to 2.0 mg/10 mL of fluoxetine and the relative standard deviation is 0.68%. The qualitative assessment of tolerable amounts of other drugs is also studied.
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Received September 21, 1998. Revision September 10, 1999.
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Khan, I., Aman, T., Iqbal, M. et al. Spectrophotometric Quantitation of Fluoxetine Hydrochloride Using Benzoyl Peroxide and Potassium Iodide. Mikrochim Acta 134, 27–31 (2000). https://doi.org/10.1007/s006040070049
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DOI: https://doi.org/10.1007/s006040070049