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No evidence of association between the D10S1423 locus and Alzheimer disease in Brazilian patients

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Summary.

In a genome survey for Alzheimer's disease (AD), Zubenko et al. (1998) reported that the 234 bp allele of the D10S1423 locus was more frequent among AD cases than in controls. We have analyzed this polymorphic locus in patients and healthy controls and observed that the 226 bp allele is the most frequent allele in the D10S1423 locus in Brazilian AD patients. However, no statistically significant association between any D10S1423 allele was observed in AD patients as well as in controls.

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Authors and Affiliations

  1. Center of the Study of the Human Genome, Department of Biology, Institute of Biosciences, University of São Paulo,, , , , ,

    A. L. Nishimura, J. R. M. Oliveira, P. A. Otto, S. R. Matioli & M. Zatz

  2. Center of Cognitive Neurology and Behaviour, University of Pernambuco, PE, and, , , , ,

    P. R. Brito-Marques

  3. Department of Neurology, Faculty of Medicine, University of São Paulo, Brazil, , , , , , BR

    V. S. Bahia & R. Nitrini

Authors
  1. A. L. Nishimura
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  2. J. R. M. Oliveira
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  3. P. A. Otto
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  4. S. R. Matioli
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  5. P. R. Brito-Marques
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  6. V. S. Bahia
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  7. R. Nitrini
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  8. M. Zatz
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Additional information

Received November 6, 2000; accepted November 9, 2000

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Nishimura, A., Oliveira, J., Otto, P. et al. No evidence of association between the D10S1423 locus and Alzheimer disease in Brazilian patients. J Neural Transm 108, 305–310 (2001). https://doi.org/10.1007/s007020170076

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  • DOI: https://doi.org/10.1007/s007020170076

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