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A practical and versatile approach toward a one-pot synthesis of 2,3-disubstituted 4(3H)-quinazolinones

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Abstract

An effective one-pot three-component route to 4(3H)-quinazolinones from commercially available starting materials is reported. Thus, isatoic anhydride reacted with ammonium acetate or primary amines and aldehydes in the presence of iodine to produce the corresponding quinazolinone derivatives in moderate to good yields.

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Acknowledgments

The authors would like to acknowledge financial support from the Research Council of Shahid Beheshti University.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Shahid Beheshti University, G. C., Evin, 1983963113, Tehran, Iran

    Minoo Dabiri, Mahboobeh Bahramnejad & Mohsen Alizadeh

  2. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, 1983963113, Tehran, Iran

    Peyman Salehi

Authors
  1. Minoo Dabiri
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  2. Peyman Salehi
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  3. Mahboobeh Bahramnejad
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  4. Mohsen Alizadeh
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Correspondence to Minoo Dabiri or Peyman Salehi.

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Dabiri, M., Salehi, P., Bahramnejad, M. et al. A practical and versatile approach toward a one-pot synthesis of 2,3-disubstituted 4(3H)-quinazolinones. Monatsh Chem 141, 877–881 (2010). https://doi.org/10.1007/s00706-010-0341-1

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  • DOI: https://doi.org/10.1007/s00706-010-0341-1

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