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Nafion-H®-catalyzed synthesis of polyhydroquinolines via the Hantzsch multicomponent reaction

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Abstract

A facile and efficient one-pot, four-component synthesis of polyhydroquinoline derivatives via the Hantzsch reaction using Nafion-H® as heterogeneous catalyst in PEG 400–water solvent system is described herein. The present methodology offers several advantages such as excellent yields, simple procedure, shorter reaction times, and milder conditions with remarkable recyclability.

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Acknowledgments

Ritika Chauhan is grateful to UGC (University Grants Commission) for providing junior research fellowship. We express our thanks to the Director of University Science and Instrumentation Centre, University of Delhi, Delhi, for providing the spectral data and also acknowledge the Head of the Biophysics Department, All India Institute of Medical Sciences, New Delhi, for carrying out the X-ray studies.

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  1. Mazaahir Kidwai

    Present address: Jiwaji University, Gwalior, Madhya Pradesh, India

Authors and Affiliations

  1. Green Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007, India

    Mazaahir Kidwai, Ritika Chauhan & Divya Bhatnagar

  2. Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India

    Abhay K. Singh, Biswajit Mishra & Sharmistha Dey

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  1. Mazaahir Kidwai
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  2. Ritika Chauhan
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Correspondence to Mazaahir Kidwai.

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Kidwai, M., Chauhan, R., Bhatnagar, D. et al. Nafion-H®-catalyzed synthesis of polyhydroquinolines via the Hantzsch multicomponent reaction. Monatsh Chem 143, 1675–1680 (2012). https://doi.org/10.1007/s00706-012-0742-4

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