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An expeditious one-pot synthesis of novel bioactive indole-substituted pyrido[2,3-d]pyrimidines using Fe3O4@SiO2-supported ionic liquid nanocatalyst

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Abstract

Novel bioactive 2-methylindole-substituted pyrido[2,3-d]pyrimidine derivatives were synthesized through an unprecedented one-pot three-component reaction of aromatic aldehydes, 6-amino-N,N-dimethyuracil, 3-(2-methyl-1H-indol-3-yl)-3-oxopropanenitrile in the presence of Fe3O4@SiO2-IL nanocatalyst as an efficient and magnetically retrievable catalyst. The assessment of antibacterial activity exhibited promising activities in most of the synthetic compounds.

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Acknowledgements

The authors are grateful to the Research Council of University of Guilan for the partial financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran

    Manouchehr Mamaghani, Mehdi Sheykhan, Mahsa Sadeghpour & Fateme Tavakoli

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  1. Manouchehr Mamaghani
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  2. Mehdi Sheykhan
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  3. Mahsa Sadeghpour
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  4. Fateme Tavakoli
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Corresponding author

Correspondence to Manouchehr Mamaghani.

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Mamaghani, M., Sheykhan, M., Sadeghpour, M. et al. An expeditious one-pot synthesis of novel bioactive indole-substituted pyrido[2,3-d]pyrimidines using Fe3O4@SiO2-supported ionic liquid nanocatalyst. Monatsh Chem 149, 1437–1446 (2018). https://doi.org/10.1007/s00706-018-2166-2

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  • DOI: https://doi.org/10.1007/s00706-018-2166-2

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