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Sulfenic acid in human serum albumin

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Summary.

Sulfenic acid (RSOH) is a central intermediate in both the reversible and irreversible redox modulation by reactive species of an increasing number of proteins involved in signal transduction and enzymatic pathways. In this paper we focus on human serum albumin (HSA), the most abundant plasma protein, proposed to serve antioxidant functions in the vascular compartment. Sulfenic acid in HSA has been previously detected using different methods after oxidation of its single free thiol Cys34 through one- or two-electron mechanisms. Since recent evidence suggests that sulfenic acid in HSA is stabilized within the protein environment, this derivative represents an appropriate model to examine protein sulfenic acid biochemistry, structure and reactivity. Sulfenic acid in HSA could be involved in mixed disufide formation, supporting a role of HSA-Cys34 as an important redox regulator in extracellular compartments.

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Abbreviations

HSA:

human serum albumin

HSA-SH:

the thiol of HSA

BSA:

bovine serum albumin

SH/HSA:

amount of thiol per albumin molecule

RSOH:

sulfenic acid

NBD-Cl:

7-chloro-4-nitrobenzo-2-oxa-1,3-diazol

DTNB:

5,5′-dithio-bis(2-nitrobenzoic acid)

dimedone:

5,5-dimethyl-1,3-cyclohexanedione

GSH:

glutathione

GSSG:

glutathione disulfide

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Authors and Affiliations

  1. Laboratorio de Enzimología, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay

    S. Carballal, B. Alvarez & L. Turell

  2. Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

    S. Carballal, H. Botti & R. Radi

  3. Center for Free Radical and Biomedical Research, Universidad de la República, Montevideo, Uruguay

    S. Carballal, B. Alvarez, L. Turell, H. Botti & R. Radi

  4. Department of Pharmacology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

    B. A. Freeman

Authors
  1. S. Carballal
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  2. B. Alvarez
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  3. L. Turell
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  4. H. Botti
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  5. B. A. Freeman
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  6. R. Radi
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Carballal, S., Alvarez, B., Turell, L. et al. Sulfenic acid in human serum albumin. Amino Acids 32, 543–551 (2007). https://doi.org/10.1007/s00726-006-0430-y

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  • DOI: https://doi.org/10.1007/s00726-006-0430-y

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