Abstract
Metal coordination of bioorganic compounds from both natural and synthetic products is not only gaining recognition in drug design and medicinal inorganic chemistry research, also they are being considered in the improvement of the bioactivity of drugs. What is done in this paper is a review of recent advances in the study of coordination-driven drug delivery, i.e., metal-based drugs (MBDs). The role of some late first row transition metal ions namely Fe, Cu and Zn in the biological activities of metallodrugs such as antimalarials and antimicrobials are highlighted. It was revealed that the interaction between these bio-essential transition metal ions and the organic drugs could enhance the diagnostic and therapeutic potentials of such formed drugs. This is because such interactions were proved to have improved the stability, bioavailability and cell delivery functions of the metallodrugs. Emphasizing on the challenge of metal ions toxicity, the researchers concluded on the need for the development of MBDs to combat drug resistant parasites without causing injury to normal cells. This would be of significance in addressing the concern World Health Organisation of ameliorating the increasing mortality rate in developing countries.
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Abbreviations
- MBDs:
-
Metal-based drugs
- CQ:
-
Chloroquine
- CQDP:
-
Chloroquine diphosphate
- QN:
-
Quinine
- ACT:
-
Amoxicilin trihydrate
- MAMDs:
-
Metal antimalarial drugs
- MAMcDs:
-
Metal antimicrobial drugs
- ATP:
-
Adenosine triphosphate
- mRNA:
-
Messenger ribonucleic acid
- tRNA:
-
Transfer ribonucleic acid
- rRNA:
-
Ribosomal ribonucleic acid
- DNA:
-
Deoxyribonucleic acid
- DDS:
-
Drug delivery system
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Acknowledgements
Professor, Anife Ahmedova of Laboratory of Biocoordination and Bioanalytical Chemistry, Department of Analytical Chemistry, Sofia University, 1, J. Bourchier Blvd., 1164 Sofia, Bulgaria is appreciated for her contribution and provision of useful materials for this article. SAA is grateful to Matsumae International Foundation (MIF), Japan and Japan Society for the Promotion of Science (JSPS) for his postdoctoral fellowships support (P13340) and the Federal University of Agriculture, Abeokuta. JAO appreciates World Bank Supported Science and Technology Education Post-Basic Project (STEP- B) and University of Ilorin Senate Research Grant Committee.
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Amolegbe, S.A., Akinremi, C.A., Adewuyi, S. et al. Some nontoxic metal-based drugs for selected prevalent tropical pathogenic diseases. J Biol Inorg Chem 22, 1–18 (2017). https://doi.org/10.1007/s00775-016-1421-4
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DOI: https://doi.org/10.1007/s00775-016-1421-4