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Myositis-specific antibodies and clinical characteristics in patients with autoimmune inflammatory myopathies: reported by the Argentine Registry of Inflammatory Myopathies of the Argentine Society of Rheumatology

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Abstract

Introduction/objectives

To describe clinical features in patients with inflammatory myopathies (IMs) from the Argentine Registry of Inflammatory Myopathies, and their relationship with myositis-specific antibodies (MSAs).

Methods

This cross-sectional study included 360 adult patients with dermatomyositis (DM), polymyositis (PM), and inclusion body myositis. Demographics, clinical, and serological characteristics were retrospectively recorded (2016–2019). MSAs were determined by immunoblotting. Patients who were positive for anti-Jo-1, Mi-2, and MDA5 were compared against a group of patients, taken as reference group, who were negative for all MSAs.

Results

Women 72%, median age at diagnosis was 47.3 years (18–82). The most frequent subtypes were DM (43.9%) followed by PM (30%).The most frequent MSAs were anti-Jo-1 (51/317), 16.1%; MDA5 (12/111), 10.8%, and Mi-2 (23/226), 10.2%. Anti-Jo-1 was associated (p < 0.05) with a higher frequency of chronic disease course, interstitial lung disease (ILD), arthritis, and mechanic’s hands. Anti-Mi-2 was found in patients who had higher frequency of skin manifestations and higher CK values (p < 0.001). Patients with anti-MDA5 had normal or low CK levels. Anti-MDA5 was associated (p < 0.05) with skin manifestations, arthritis, and ILD. The rest of MSAs had frequencies lower than 8%. Anti-TIF1ϒ was found in eight DM patients and one had cancer. Anti-SRP was found in seven patients who had PM and elevated CK.

Conclusion

Anti-Jo-1 was the most frequent MSA, and was associated with ILD; MDA5 was associated with CADM and ILD, and Mi-2, with classical DM. Despite the different prevalence with respect to other cohorts, the clinical characteristics for each MSA group were similar to the data reported in other studies.

Key Points

• This study describes the prevalence of MSAs in the Argentine Registry of IMs.

• Anti-Jo-1 and anti-MDA5 were associated with ILD.

• Anti-Mi-2 was the third most frequent MSA, associated with classical DM.

 

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Acknowledgements

On behalf of Myositis Study Group Yessica Ponce13, Oscar Rillo13, Sebastian Magri14, Marina Micelli15, Isabel Pineda16, Cecilia Abate17, Ramiro Puerta Franchi18, Susana Visentin19, Paula Kohan20, Hospital Ignacio Pirovano13(Buenos Aires city), Hospital Italiano de La Plata14 (Province of Buenos Aires), Hospital Ramos Mejía15 (Buenos Aires city), Venado Tuerto16 (Province of Santa Fe), Hospital Evita17, Lanús (Province of Buenos Aires), Hospital Houssay18, Vicente Lopez (Province of Buenos Aires), Hospital Durand19 (Buenos Aires city), Hospital Federico Larcade20, San Miguel (Province of Buenos Aires), and to Maria A Lazaro, Darío Scublinski, Monica Heredia, Sofia Velez, from their private medical office.

We thank Technician Lorena Suarez and Biochemist Dr. Angeles Gargiulo for providing results for autoantibodies testing and Dr. Marina Khoury for her methodological assistance.

Funding

The commercial kit (EUROLINE Autoimmune Inflammatory Myopathies 16 Ag-IgG) for the determination of part of the myositis-specific antibodies was bought with a grant from the Argentinian Rheumatology Society.

Author information

Authors and Affiliations

  1. Department of Immunology, Instituto de Investigaciones Médicas Alfredo Lanari, Buenos Aires University, Autonomous City of Buenos Aires, 3150 Combatientes de Malvinas Ave, 1431, PC, Argentina

    Graciela N. Gómez & Nicolás Pérez

  2. Department of Rheumatology, Hospital de Clínicas, José de San Martín, Buenos Aires University, Autonomous City of Buenos Aires, Argentina

    Andrea Braillard Poccard & Ramiro A. Gómez

  3. Department of Rheumatology, Province of Buenos Aires, H.I.G.A San Martín, La Plata City, Argentina

    Ana C. Costi & Mercedes A. García

  4. Department of Rheumatology, Hospital General de Agudos Dr. Cosme Argerich, Autonomous City of Buenos Aires, Argentina

    Malena Viola & Alejandro Benitez

  5. Department of Rheumatology, Hospital Nuestro Señor del Milagro, Salta City, Province of Salta, Argentina

    Mariana M. Aciar & María Crespo Espíndola

  6. Department of Rheumatology, Sanatorio Güemes, Autonomous City of Buenos Aires, Argentina

    Demelza Yucra

  7. Department of Rheumatology, CEMIC, Autonomous City of Buenos Aires, Argentina

    Micaela A. Cosatti & Cecilia Pisoni

  8. Department of Rheumatology, Instituto de Rehabilitación Psicofsica (IREP), Autonomous City of Buenos Aires, Argentina

    Dafne Capelusnik

  9. Department of Rheumatology, Hospital Rossi, La Plata City, Province of Buenos Aires, Argentina

    María N. Lojo

  10. Department of Rheumatology, Hospital Enrique Tornú, Autonomous City of Buenos Aires, Argentina

    Belen I. Barrios

  11. Department of Rheumatology, British Hospital, Autonomous City of Buenos Aires, Argentina

    Mariano Rivero

  12. Department of Rheumatology, Hospital Eva Perón, Granadero Baigorria City, Province of Santa Fe, Argentina

    Boris Kisluk

  13. Department of Rheumatology, Hospital San Roque, La Plata City, Province of Buenos Aires, Argentina

    Amelia Granel

Authors
  1. Graciela N. Gómez
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  2. Nicolás Pérez
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  3. Andrea Braillard Poccard
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  4. Ramiro A. Gómez
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  18. Boris Kisluk
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  19. Amelia Granel
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Contributions

Dr. Graciela Gómez and Dr. Amelia Granel had full access to all of the data in the study and take the responsibility for the integrity of the data and accuracy of the data analysis. All the coauthors entered patients into the registry and reviewed the draft and final version of the manuscript.

Study concept and design: Dr. Graciela N Gómez and Dr. Amelia Granel.

Data acquisition, analysis, and interpretation of results: Dr. Graciela N Gómez and Dr. Marina Khoury.

Corresponding author

Correspondence to Graciela N. Gómez.

Ethics declarations

Ethics approval

The Registry has the approval of the Teaching and Research Committee and the Ethics Committee of the Instituto de Investigaciones Médicas Alfredo Lanari, of the Universidad de Buenos Aires (UBA).

Consent to participate

Subjects who were entered into the Registry must have to sign an informed consent.

Disclosures

None.

Additional information

Previously been published as an abstract: ACR Meeting Abstracts Abstract number 1276. Citation: Myositis Specific Antibodies and Clinical Features in Patients from Argentina [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/myositisspecic-antibodies-and-clinical-features-in-patients-from-argentina/.

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Gómez, G.N., Pérez, N., Braillard Poccard, A. et al. Myositis-specific antibodies and clinical characteristics in patients with autoimmune inflammatory myopathies: reported by the Argentine Registry of Inflammatory Myopathies of the Argentine Society of Rheumatology. Clin Rheumatol 40, 4473–4483 (2021). https://doi.org/10.1007/s10067-021-05797-2

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