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The correlation of lymphocyte subsets, natural killer cell, and Parkinson’s disease: a meta-analysis

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Abstract

The correlation between immunity and Parkinson’s disease was presented in many papers, which also discussed lymphocyte and natural killer cell. But these studies have yielded inconsistent results. To systematically review the relationship between the lymphocyte subsets/natural killer cell and the risk of Parkinson’s disease, we electronically searched the SpringerLink, Web of Science, Ebsco-medline with full text, Pubmed, Elsevier-ScienceDirect, Ovid-lww-oup, Wanfang Data for case-control trials on comparing the number of peripheral blood lymphocyte subsets and natural killer cell in Parkinson’s patients and healthy controls. According to the Cochrane methods, the reviewers selected literature, extracted data, and assessed the quality. Then, a meta-analysis was performed using RevMan 5.2. Finally, 21 case-control trials including 943 cases of Parkinson’s disease were fit into our data analysis. Meta-analysis showed that the decreased numbers of CD3+, CD4+ lymphocyte subsets and the increased number of natural killer cell were found in Parkinson’s disease patients. In the intermediate and late stage of PD, CD8+ lymphocyte subsets had a significant decrement. However, the number of B lymphocyte subsets had no significant association with Parkinson’s disease. The lymphocyte subsets and NK cell may be associated with the risk of Parkinson’s disease.

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Acknowledgements

We thank anonymous reviewers for revision of this manuscript.

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Authors and Affiliations

  1. Department of Neurology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China

    Sen Jiang & Pengfei Wang

  2. Department of Neurology, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, China

    Hua Gao

  3. Department of Medicine, Tumor Hospital Affiliated of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China

    Qin Luo

  4. Department of Neurology, Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China

    Xinling Yang

Authors
  1. Sen Jiang
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  2. Hua Gao
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  3. Qin Luo
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  4. Pengfei Wang
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  5. Xinling Yang
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Correspondence to Xinling Yang.

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The authors declare that they have no conflict of interest.

Funding

This work was supported by the grants from the National Natural Science Foundation of China (grant numbers U1503222).

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Jiang, S., Gao, H., Luo, Q. et al. The correlation of lymphocyte subsets, natural killer cell, and Parkinson’s disease: a meta-analysis. Neurol Sci 38, 1373–1380 (2017). https://doi.org/10.1007/s10072-017-2988-4

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  • DOI: https://doi.org/10.1007/s10072-017-2988-4

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