Abstract
Skin biopsy represents an attractive technique to evaluate the extensive innervation of human epidermis, as demonstrated by the immunoreactivity of the intra-epidermal nerve fibers to the marker protein gene product 9.5. Intra-epidermal nerve fibers can be reliably quantified, and their density correlates with both the presence and the severity of sensory neuropathy. The first description of nerve fibers within human epidermis was published by Paul Langerhans. However, the limitations imposed by the relatively insensitive staining methods led several investigators working during the following century to deny or minimize their existence. The author reviews the assumptions and the striking discrepancies emerging from the wide literature on cutaneous sensory terminations since the late nineteenth century and highlights the new developments emerging from the most recent works.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 24 November 1998 / Accepted: 5 February 1999
Rights and permissions
About this article
Cite this article
Lauria, G. Innervation of the human epidermis. A historical review. Ital J Neurol Sci 20, 63–70 (1999). https://doi.org/10.1007/s100720050013
Issue Date:
DOI: https://doi.org/10.1007/s100720050013