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Models of cardiac electromechanics based on individual hearts imaging data

Image-based electromechanical models of the heart

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Biomechanics and Modeling in Mechanobiology Aims and scope Submit manuscript

An Erratum to this article was published on 09 January 2011

Abstract

Current multi-scale computational models of ventricular electromechanics describe the full process of cardiac contraction on both the micro- and macro- scales including: the depolarization of cardiac cells, the release of calcium from intracellular stores, tension generation by cardiac myofilaments, and mechanical contraction of the whole heart. Such models are used to reveal basic mechanisms of cardiac contraction as well as the mechanisms of cardiac dysfunction in disease conditions. In this paper, we present a methodology to construct finite element electromechanical models of ventricular contraction with anatomically accurate ventricular geometry based on magnetic resonance and diffusion tensor magnetic resonance imaging of the heart. The electromechanical model couples detailed representations of the cardiac cell membrane, cardiac myofilament dynamics, electrical impulse propagation, ventricular contraction, and circulation to simulate the electrical and mechanical activity of the ventricles. The utility of the model is demonstrated in an example simulation of contraction during sinus rhythm using a model of the normal canine ventricles.

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Authors and Affiliations

  1. Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles St., CSEB Room 218, Baltimore, MD, 21218, USA

    Viatcheslav Gurev, Ted Lee, Jason Constantino, Hermenegild Arevalo & Natalia A. Trayanova

Authors
  1. Viatcheslav Gurev
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  2. Ted Lee
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  3. Jason Constantino
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  4. Hermenegild Arevalo
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  5. Natalia A. Trayanova
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Correspondence to Viatcheslav Gurev.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s10237-010-0283-x

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Gurev, V., Lee, T., Constantino, J. et al. Models of cardiac electromechanics based on individual hearts imaging data. Biomech Model Mechanobiol 10, 295–306 (2011). https://doi.org/10.1007/s10237-010-0235-5

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  • DOI: https://doi.org/10.1007/s10237-010-0235-5

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